STRINGSTRING
SNAI1 SNAI1 SMAD3 SMAD3 TCF7L2 TCF7L2 M3XSG3_MUSPF M3XSG3_MUSPF WWTR1 WWTR1 LOXL2 LOXL2 TGFB2 TGFB2 BCL9L BCL9L LRG1 LRG1 FERMT2 FERMT2 BMP4 BMP4 GLIPR2 GLIPR2 BMP2 BMP2 TGFBR1 TGFBR1 EZH2 EZH2 TBX20 TBX20 SMAD4 SMAD4 LEF1 LEF1 ZNF703 ZNF703 NOTCH1 NOTCH1 TGFB1I1 TGFB1I1 CTNNB1 CTNNB1 ENG ENG IL6 IL6 CRB2 CRB2 AXIN2 AXIN2 DAB2 DAB2 BAMBI BAMBI PDPN PDPN MTOR MTOR TGFB1 TGFB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNAI1Snail family transcriptional repressor 1. (264 aa)
SMAD3Mothers against decapentaplegic homolog. (414 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
M3XSG3_MUSPFCTNNB1_binding domain-containing protein. (169 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
LOXL2Lysyl oxidase like 2. (772 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
BCL9LBCL9 like. (1276 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (354 aa)
FERMT2Fermitin family member 2. (706 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (151 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (480 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (753 aa)
TBX20T-box transcription factor 20. (446 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LEF1Lymphoid enhancer binding factor 1. (400 aa)
ZNF703Zinc finger protein 703. (545 aa)
NOTCH1Notch receptor 1. (2119 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (470 aa)
CTNNB1Catenin beta 1. (781 aa)
ENGEndoglin. (653 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
CRB2Crumbs cell polarity complex component 2. (1195 aa)
AXIN2Axin 2. (842 aa)
DAB2Disabled-like protein 2, mitogen-responsive phosphoprotein. (769 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
PDPNPodoplanin. (177 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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