(25 nodes) Regulation of cholesterol efflux network (Mustela putorius)

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second shell of interactors

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Your Input:
	TTC39A	Tetratricopeptide repeat domain 39A. (578 aa)
	PTCH1	Patched 1. (1386 aa)
	ABCG4	ATP binding cassette subfamily G member 4. (646 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	PLA2G10	Phospholipase A(2). (159 aa)
	TREML1	Triggering receptor expressed on myeloid cells like 1. (314 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	SIRT1	Sirtuin 1. (557 aa)
	PLTP	Phospholipid transfer protein. (483 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
	ABCA7	ATP binding cassette subfamily A member 7. (2152 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1104 aa)
	M3Z4M4_MUSPF	Uncharacterized protein. (588 aa)
	M3XP26_MUSPF	Uncharacterized protein. (265 aa)
	EEPD1	Endonuclease/exonuclease/phosphatase family domain containing 1. (569 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2598 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	PON1	Paraoxonase 1. (355 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (447 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (323 aa)
	ZDHHC8	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (778 aa)
	NAXE	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (287 aa)
	TTC39B	Tetratricopeptide repeat domain 39B. (682 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (460 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA7	TREM2	ENSMPUP00000008944	ENSMPUP00000013551	ATP binding cassette subfamily A member 7.	Triggering receptor expressed on myeloid cells 2.	0.596
ABCA7	TREML1	ENSMPUP00000008944	ENSMPUP00000013574	ATP binding cassette subfamily A member 7.	Triggering receptor expressed on myeloid cells like 1.	0.596
ADIPOQ	CAV1	ENSMPUP00000003314	ENSMPUP00000007166	Adiponectin, C1Q and collagen domain containing.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.410
ADIPOQ	SIRT1	ENSMPUP00000003314	ENSMPUP00000011868	Adiponectin, C1Q and collagen domain containing.	Sirtuin 1.	0.511
APOA1	PLTP	ENSMPUP00000004184	ENSMPUP00000017499	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	Phospholipid transfer protein.	0.795
APOA1	PON1	ENSMPUP00000004184	ENSMPUP00000001563	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	Paraoxonase 1.	0.517
CAV1	ADIPOQ	ENSMPUP00000007166	ENSMPUP00000003314	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Adiponectin, C1Q and collagen domain containing.	0.410
M3XP26_MUSPF	NR1H2	ENSMPUP00000000826	ENSMPUP00000001918	Uncharacterized protein.	Nuclear receptor subfamily 1 group H member 2.	0.479
M3XP26_MUSPF	NR1H3	ENSMPUP00000000826	ENSMPUP00000004749	Uncharacterized protein.	Nuclear receptor subfamily 1 group H member 3.	0.479
NR1H2	M3XP26_MUSPF	ENSMPUP00000001918	ENSMPUP00000000826	Nuclear receptor subfamily 1 group H member 2.	Uncharacterized protein.	0.479
NR1H2	NR1H3	ENSMPUP00000001918	ENSMPUP00000004749	Nuclear receptor subfamily 1 group H member 2.	Nuclear receptor subfamily 1 group H member 3.	0.930
NR1H2	PLTP	ENSMPUP00000001918	ENSMPUP00000017499	Nuclear receptor subfamily 1 group H member 2.	Phospholipid transfer protein.	0.481
NR1H3	M3XP26_MUSPF	ENSMPUP00000004749	ENSMPUP00000000826	Nuclear receptor subfamily 1 group H member 3.	Uncharacterized protein.	0.479
NR1H3	NR1H2	ENSMPUP00000004749	ENSMPUP00000001918	Nuclear receptor subfamily 1 group H member 3.	Nuclear receptor subfamily 1 group H member 2.	0.930
NR1H3	SREBF2	ENSMPUP00000004749	ENSMPUP00000016269	Nuclear receptor subfamily 1 group H member 3.	Sterol regulatory element binding transcription factor 2.	0.501
PLTP	APOA1	ENSMPUP00000017499	ENSMPUP00000004184	Phospholipid transfer protein.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.795
PLTP	NR1H2	ENSMPUP00000017499	ENSMPUP00000001918	Phospholipid transfer protein.	Nuclear receptor subfamily 1 group H member 2.	0.481
PLTP	PON1	ENSMPUP00000017499	ENSMPUP00000001563	Phospholipid transfer protein.	Paraoxonase 1.	0.685
PON1	APOA1	ENSMPUP00000001563	ENSMPUP00000004184	Paraoxonase 1.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.517
PON1	PLTP	ENSMPUP00000001563	ENSMPUP00000017499	Paraoxonase 1.	Phospholipid transfer protein.	0.685