STRINGSTRING
LEPR LEPR RB1 RB1 SHANK3 SHANK3 CSF1 CSF1 SOX4 SOX4 GBA GBA LGI4 LGI4 GFAP GFAP TP53 TP53 MECP2 MECP2 ORC3 ORC3 KRAS KRAS IL34 IL34 VEGFC VEGFC NF2 NF2 TREM2 TREM2 TREML1 TREML1 CSF1R CSF1R NF1 NF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEPRLeptin receptor. (1164 aa)
RB1RB transcriptional corepressor 1. (948 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1712 aa)
CSF1Colony stimulating factor 1. (517 aa)
SOX4SRY-box transcription factor 4. (269 aa)
GBAGlucosylceramidase. (547 aa)
LGI4Leucine rich repeat LGI family member 4. (537 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (457 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (484 aa)
ORC3Origin recognition complex subunit 3. (711 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
IL34Interleukin 34. (236 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (370 aa)
NF2Neurofibromin 2. (591 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (314 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (978 aa)
NF1Neurofibromin 1. (2815 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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