(69 nodes) Primary neural tube formation network (Mustela putorius)

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	MKS1	MKS transition zone complex subunit 1. (559 aa)
	PHACTR4	Phosphatase and actin regulator. (708 aa)
	GRHL3	Grainyhead like transcription factor 3. (602 aa)
	LUZP1	Leucine zipper protein 1. (1073 aa)
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (654 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
	BBS4	Bardet-Biedl syndrome 4. (507 aa)
	SALL4	Spalt like transcription factor 4. (1097 aa)
	TGFB1	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
	SPINT2	Serine peptidase inhibitor, Kunitz type, 2. (252 aa)
	CECR2	CECR2 histone acetyl-lysine reader. (1368 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	COBL	Cordon-bleu WH2 repeat protein. (1316 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (832 aa)
	LRP2	LDL receptor related protein 2. (4699 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	BRD2	Bromodomain containing 2. (803 aa)
	KDM2B	Lysine demethylase 2B. (1310 aa)
	CC2D2A	Coiled-coil and C2 domain containing 2A. (1621 aa)
	PLXNB2	Plexin B2. (1841 aa)
	FUZ	Fuzzy planar cell polarity protein. (392 aa)
	DVL3	Dishevelled segment polarity protein 3. (718 aa)
	CELSR1	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2735 aa)
	TEAD2	TEA domain transcription factor 2. (545 aa)
	OPA1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
	GLMN	Glomulin, FKBP associated protein. (600 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	MED12	Mediator complex subunit 12. (2168 aa)
	LMO4	LIM domain only 4. (165 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1500 aa)
	HECTD1	HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
	BCL10	BCL10 immune signaling adaptor. (241 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	M3Y377_MUSPF	NTR domain-containing protein. (233 aa)
	VASP	Vasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (382 aa)
	LIAS	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (362 aa)
	RARG	Retinoic acid receptor gamma. (458 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (824 aa)
	MTHFD1	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (935 aa)
	PTCH1	Patched 1. (1386 aa)
	SCRIB	Scribble planar cell polarity protein. (1523 aa)
	SHROOM3	Shroom family member 3. (1723 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1285 aa)
	ST14	Suppression of tumorigenicity 14. (859 aa)
	SPINT1	Serine peptidase inhibitor, Kunitz type 1. (521 aa)
	LRRC1	Leucine rich repeat containing 1. (524 aa)
	TULP3	Tubby-like protein; Belongs to the TUB family. (462 aa)
	IFT57	Intraflagellar transport 57. (429 aa)
	M3YFG7_MUSPF	Uncharacterized protein. (135 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (918 aa)
	DVL2	Dishevelled segment polarity protein 2. (734 aa)
	KAT2A	Lysine acetyltransferase 2A. (869 aa)
	SEMA4C	Semaphorin 4C; Belongs to the semaphorin family. (867 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	TSC1	TSC complex subunit 1. (1165 aa)
	ABL1	Tyrosine-protein kinase. (1150 aa)
	KDM6A	Lysine demethylase 6A. (1419 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
	TRIM71	Tripartite motif containing 71. (514 aa)
	LHX2	LIM homeobox 2. (406 aa)
	DVL1	Dishevelled segment polarity protein 1. (691 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2564 aa)
	CLUAP1	Clusterin associated protein 1. (437 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (282 aa)
	M3YUX6_MUSPF	Uncharacterized protein. (497 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	VASP	ENSMPUP00000012584	ENSMPUP00000005832	Tyrosine-protein kinase.	Vasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family.	0.636
BBS4	CLUAP1	ENSMPUP00000017060	ENSMPUP00000014991	Bardet-Biedl syndrome 4.	Clusterin associated protein 1.	0.549
BBS4	IFT57	ENSMPUP00000017060	ENSMPUP00000009896	Bardet-Biedl syndrome 4.	Intraflagellar transport 57.	0.799
BBS4	M3YFG7_MUSPF	ENSMPUP00000017060	ENSMPUP00000010074	Bardet-Biedl syndrome 4.	Uncharacterized protein.	0.426
BCL10	TRAF6	ENSMPUP00000005407	ENSMPUP00000011691	BCL10 immune signaling adaptor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.894
BMP4	NODAL	ENSMPUP00000005423	ENSMPUP00000004259	Bone morphogenetic protein 4.	Nodal growth differentiation factor.	0.405
BMP4	PTCH1	ENSMPUP00000005423	ENSMPUP00000006660	Bone morphogenetic protein 4.	Patched 1.	0.537
CC2D2A	MKS1	ENSMPUP00000002103	ENSMPUP00000015236	Coiled-coil and C2 domain containing 2A.	MKS transition zone complex subunit 1.	0.979
CELSR1	DVL1	ENSMPUP00000002489	ENSMPUP00000014246	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Dishevelled segment polarity protein 1.	0.545
CELSR1	DVL2	ENSMPUP00000002489	ENSMPUP00000010405	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Dishevelled segment polarity protein 2.	0.798
CELSR1	DVL3	ENSMPUP00000002489	ENSMPUP00000002416	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Dishevelled segment polarity protein 3.	0.490
CELSR1	FZD3	ENSMPUP00000002489	ENSMPUP00000000974	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.770
CELSR1	PRICKLE1	ENSMPUP00000002489	ENSMPUP00000000342	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Prickle planar cell polarity protein 1.	0.762
CELSR1	PTK7	ENSMPUP00000002489	ENSMPUP00000013001	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.536
CELSR1	SCRIB	ENSMPUP00000002489	ENSMPUP00000008091	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Scribble planar cell polarity protein.	0.637
CELSR1	SHROOM3	ENSMPUP00000002489	ENSMPUP00000008331	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Shroom family member 3.	0.594
CITED2	HIF1A	ENSMPUP00000018764	ENSMPUP00000006460	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	Hypoxia inducible factor 1 subunit alpha.	0.497
CITED2	SETD2	ENSMPUP00000018764	ENSMPUP00000014934	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	SET domain containing 2, histone lysine methyltransferase.	0.405
CLUAP1	BBS4	ENSMPUP00000014991	ENSMPUP00000017060	Clusterin associated protein 1.	Bardet-Biedl syndrome 4.	0.549
CLUAP1	IFT57	ENSMPUP00000014991	ENSMPUP00000009896	Clusterin associated protein 1.	Intraflagellar transport 57.	0.995