(12 nodes) Positive regulation of smooth muscle cell migration network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	IGFBP5	Insulin like growth factor binding protein 5. (271 aa)
	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif 1. (953 aa)
	VTN	SMB domain-containing protein. (470 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1137 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (242 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	AIF1	Allograft inflammatory factor 1. (147 aa)
	SEMA6D	Semaphorin 6D; Belongs to the semaphorin family. (1082 aa)
	DOCK4	Dedicator of cytokinesis 4; Belongs to the DOCK family. (1968 aa)
	DOCK7	Dedicator of cytokinesis 7; Belongs to the DOCK family. (2143 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (638 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IGF1	IGFBP5	ENSMPUP00000011884	ENSMPUP00000016396	Insulin like growth factor 1.	Insulin like growth factor binding protein 5.	0.632
IGF1	PDGFB	ENSMPUP00000011884	ENSMPUP00000013167	Insulin like growth factor 1.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.732
IGFBP5	IGF1	ENSMPUP00000016396	ENSMPUP00000011884	Insulin like growth factor binding protein 5.	Insulin like growth factor 1.	0.632
PDGFB	IGF1	ENSMPUP00000013167	ENSMPUP00000011884	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	Insulin like growth factor 1.	0.732
PDGFB	PDGFRB	ENSMPUP00000013167	ENSMPUP00000013885	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.999
PDGFRB	PDGFB	ENSMPUP00000013885	ENSMPUP00000013167	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.999