(36 nodes) Potassium channel regulator activity network (Mustela putorius)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	DPP6	Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family. (803 aa)
	SGK3	Serum/glucocorticoid regulated kinase family member 3. (355 aa)
	WNK4	WNK lysine deficient protein kinase 4. (1242 aa)
	WNK3	WNK lysine deficient protein kinase 3. (1731 aa)
	KCNIP1	Potassium voltage-gated channel interacting protein 1. (227 aa)
	KCNIP2	Kv channel-interacting protein 2; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Essential for the expression of I(To) currents in the heart. Required for normal protein levels of KCND2 in the heart ventricle (By similarity); Belongs to the recoverin family. (252 aa)
	M3Z0I5_MUSPF	KcnmB2_inactiv domain-containing protein. (261 aa)
	KCNMB3	Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (285 aa)
	M3Z176_MUSPF	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (221 aa)
	KCNMB4	Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
	KCNS1	Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family. (498 aa)
	SGK2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (390 aa)
	WNK1	WNK lysine deficient protein kinase 1. (2832 aa)
	AMIGO2	Adhesion molecule with Ig like domain 2. (521 aa)
	KCNE2	Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
	M3Z6U8_MUSPF	Small ubiquitin-related modifier. (100 aa)
	KCNE3	Potassium voltage-gated channel subfamily E regulatory subunit 3. (99 aa)
	KCNE4	Potassium voltage-gated channel subfamily E regulatory subunit 4. (170 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (251 aa)
	LRRC26	Leucine rich repeat containing 26. (246 aa)
	LRRC38	Leucine rich repeat containing 38. (299 aa)
	NEDD4L	NEDD4 like E3 ubiquitin protein ligase. (999 aa)
	LRRC55	Leucine rich repeat containing 55. (318 aa)
	M3XQH2_MUSPF	Uncharacterized protein. (130 aa)
	KCNAB1	Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (401 aa)
	AMIGO1	Adhesion molecule with Ig like domain 1. (493 aa)
	LRRC52	Leucine rich repeat containing 52. (315 aa)
	WNK2	WNK lysine deficient protein kinase 2. (1899 aa)
	KCNAB2	Potassium voltage-gated channel subfamily A regulatory beta subunit 2. (382 aa)
	KCNIP4	Potassium voltage-gated channel interacting protein 4. (213 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	M3YB65_MUSPF	PX domain-containing protein. (68 aa)
	KCNAB3	Potassium voltage-gated channel subfamily A regulatory beta subunit 3. (405 aa)
	PDZD4	PDZ domain containing 4. (756 aa)
	KCNIP3	Potassium voltage-gated channel interacting protein 3. (284 aa)
	FLNA	Filamin A. (2647 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV1	FLNA	ENSMPUP00000007166	ENSMPUP00000009219	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Filamin A.	0.637
DPP6	KCNE2	ENSMPUP00000009334	ENSMPUP00000019101	Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.433
DPP6	KCNE3	ENSMPUP00000009334	ENSMPUP00000019405	Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family.	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.417
DPP6	KCNIP1	ENSMPUP00000009334	ENSMPUP00000012793	Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family.	Potassium voltage-gated channel interacting protein 1.	0.786
DPP6	KCNIP2	ENSMPUP00000009334	ENSMPUP00000016787	Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family.	Kv channel-interacting protein 2; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Essential for the expression of I(To) currents in the heart. Required for normal protein levels of KCND2 in the heart ventricle (By similarity); Belongs to the recoverin family.	0.563
DPP6	KCNIP3	ENSMPUP00000009334	ENSMPUP00000009039	Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family.	Potassium voltage-gated channel interacting protein 3.	0.574
DPP6	M3XQH2_MUSPF	ENSMPUP00000009334	ENSMPUP00000001322	Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family.	Uncharacterized protein.	0.424
FLNA	CAV1	ENSMPUP00000009219	ENSMPUP00000007166	Filamin A.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.637
KCNAB1	KCNIP1	ENSMPUP00000002766	ENSMPUP00000012793	Potassium voltage-gated channel subfamily A member regulatory beta subunit 1.	Potassium voltage-gated channel interacting protein 1.	0.446
KCNAB1	KCNS1	ENSMPUP00000002766	ENSMPUP00000017531	Potassium voltage-gated channel subfamily A member regulatory beta subunit 1.	Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family.	0.557
KCNAB2	KCNIP1	ENSMPUP00000007097	ENSMPUP00000012793	Potassium voltage-gated channel subfamily A regulatory beta subunit 2.	Potassium voltage-gated channel interacting protein 1.	0.418
KCNAB2	KCNS1	ENSMPUP00000007097	ENSMPUP00000017531	Potassium voltage-gated channel subfamily A regulatory beta subunit 2.	Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family.	0.557
KCNAB3	KCNS1	ENSMPUP00000008776	ENSMPUP00000017531	Potassium voltage-gated channel subfamily A regulatory beta subunit 3.	Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family.	0.650
KCNE2	DPP6	ENSMPUP00000019101	ENSMPUP00000009334	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family.	0.433
KCNE2	KCNE3	ENSMPUP00000019101	ENSMPUP00000019405	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.861
KCNE2	KCNE4	ENSMPUP00000019101	ENSMPUP00000019965	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.769
KCNE2	KCNIP2	ENSMPUP00000019101	ENSMPUP00000016787	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Kv channel-interacting protein 2; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Essential for the expression of I(To) currents in the heart. Required for normal protein levels of KCND2 in the heart ventricle (By similarity); Belongs to the recoverin family.	0.461
KCNE3	DPP6	ENSMPUP00000019405	ENSMPUP00000009334	Potassium voltage-gated channel subfamily E regulatory subunit 3.	Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family.	0.417
KCNE3	KCNE2	ENSMPUP00000019405	ENSMPUP00000019101	Potassium voltage-gated channel subfamily E regulatory subunit 3.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.861
KCNE3	KCNE4	ENSMPUP00000019405	ENSMPUP00000019965	Potassium voltage-gated channel subfamily E regulatory subunit 3.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.764