(56 nodes) Transcription repressor complex network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LIN54	Lin-54 DREAM MuvB core complex component. (749 aa)
	M3XM17_MUSPF	Uncharacterized protein. (208 aa)
	MIER1	MIER1 transcriptional regulator. (470 aa)
	M3XP26_MUSPF	Uncharacterized protein. (265 aa)
	M3XPQ5_MUSPF	WD_REPEATS_REGION domain-containing protein. (366 aa)
	INSM1	INSM transcriptional repressor 1. (464 aa)
	NCOR2	Nuclear receptor corepressor 2. (2525 aa)
	RCOR1	REST corepressor 1. (376 aa)
	M3XUB3_MUSPF	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (445 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (673 aa)
	HDGF	Heparin binding growth factor. (209 aa)
	DR1	Down-regulator of transcription 1. (175 aa)
	GFI1	Growth factor independent 1 transcriptional repressor. (386 aa)
	GMNN	Geminin DNA replication inhibitor. (210 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	JUND	JunD proto-oncogene, AP-1 transcription factor subunit. (347 aa)
	INSM2	INSM transcriptional repressor 2. (557 aa)
	GLI3	GLI family zinc finger 3. (1585 aa)
	ENSMPUP00000018030	annotation not available (113 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
	SIN3A	SIN3 transcription regulator family member A. (1550 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (514 aa)
	SPEN	Spen family transcriptional repressor. (3614 aa)
	M3YUJ9_MUSPF	HMG box domain-containing protein. (171 aa)
	TFAP4	Transcription factor AP-4. (365 aa)
	PHF12	PHD finger protein 12. (1022 aa)
	SP3	Sp3 transcription factor. (695 aa)
	HOXC9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
	GATA1	GATA binding protein 1. (414 aa)
	BIN1	Bridging integrator 1. (594 aa)
	DRAP1	DR1 associated protein 1. (185 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (429 aa)
	NCOR1	Nuclear receptor corepressor 1. (2510 aa)
	FOXO3	Forkhead box O3. (671 aa)
	LIN52	Lin-52 DREAM MuvB core complex component. (111 aa)
	ELANE	Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (265 aa)
	AKIRIN2	Akirin 2. (203 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
	LIN9	Lin-9 DREAM MuvB core complex component. (553 aa)
	M3XZP3_MUSPF	HMG box domain-containing protein. (215 aa)
	REST	RE1 silencing transcription factor. (1098 aa)
	JAZF1	JAZF zinc finger 1. (208 aa)
	DDX20	DEAD-box helicase 20. (823 aa)
	RBBP8	RB binding protein 8, endonuclease. (897 aa)
	CBX5	Chromobox 5. (191 aa)
	PRDM10	PR/SET domain 10. (1161 aa)
	M3YA12_MUSPF	Uncharacterized protein. (3437 aa)
	M3YA03_MUSPF	Uncharacterized protein. (666 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (430 aa)
	MXD1	MAX dimerization protein 1. (221 aa)
	CORO2A	Coronin; Belongs to the WD repeat coronin family. (520 aa)
	C1D	C1D nuclear receptor corepressor. (141 aa)
	ARID4A	AT-rich interaction domain 4A. (1257 aa)
	LIN37	Lin-37 DREAM MuvB core complex component. (246 aa)
	SP1	Sp1 transcription factor. (787 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID4A	HDAC3	ENSMPUP00000006085	ENSMPUP00000008127	AT-rich interaction domain 4A.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.924
ARID4A	M3XM17_MUSPF	ENSMPUP00000006085	ENSMPUP00000000117	AT-rich interaction domain 4A.	Uncharacterized protein.	0.438
ARID4A	M3XZP3_MUSPF	ENSMPUP00000006085	ENSMPUP00000004544	AT-rich interaction domain 4A.	HMG box domain-containing protein.	0.438
ARID4A	M3YUJ9_MUSPF	ENSMPUP00000006085	ENSMPUP00000015009	AT-rich interaction domain 4A.	HMG box domain-containing protein.	0.438
ARID4A	PHF12	ENSMPUP00000006085	ENSMPUP00000014020	AT-rich interaction domain 4A.	PHD finger protein 12.	0.875
ARID4A	RCOR1	ENSMPUP00000006085	ENSMPUP00000002613	AT-rich interaction domain 4A.	REST corepressor 1.	0.612
ARID4A	REST	ENSMPUP00000006085	ENSMPUP00000004692	AT-rich interaction domain 4A.	RE1 silencing transcription factor.	0.568
ARID4A	SIN3A	ENSMPUP00000006085	ENSMPUP00000017213	AT-rich interaction domain 4A.	SIN3 transcription regulator family member A.	0.920
BIN1	MXD1	ENSMPUP00000011941	ENSMPUP00000007050	Bridging integrator 1.	MAX dimerization protein 1.	0.432
CCND1	HDAC3	ENSMPUP00000004532	ENSMPUP00000008127	Cyclin D1; Belongs to the cyclin family.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.670
CCND1	JUN	ENSMPUP00000004532	ENSMPUP00000020047	Cyclin D1; Belongs to the cyclin family.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.684
CCND1	MDM2	ENSMPUP00000004532	ENSMPUP00000017394	Cyclin D1; Belongs to the cyclin family.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.622
CCND1	TP53	ENSMPUP00000004532	ENSMPUP00000008945	Cyclin D1; Belongs to the cyclin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.756
CTBP1	ENSMPUP00000018030	ENSMPUP00000011090	ENSMPUP00000018030	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	annotation not available	0.868
CTBP1	HDAC3	ENSMPUP00000011090	ENSMPUP00000008127	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.442
CTBP1	M3XUB3_MUSPF	ENSMPUP00000011090	ENSMPUP00000002663	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.870
CTBP1	NCOR2	ENSMPUP00000011090	ENSMPUP00000001405	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Nuclear receptor corepressor 2.	0.538
CTBP1	RBBP8	ENSMPUP00000011090	ENSMPUP00000005622	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	RB binding protein 8, endonuclease.	0.945
CTBP1	RCOR1	ENSMPUP00000011090	ENSMPUP00000002613	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	REST corepressor 1.	0.564
DDX20	FOXO3	ENSMPUP00000004881	ENSMPUP00000009773	DEAD-box helicase 20.	Forkhead box O3.	0.413