STRINGSTRING
ZNF207 ZNF207 NEK6 NEK6 GEN1 GEN1 AFMID AFMID BIRC5 BIRC5 SPDL1 SPDL1 MAD2L1BP MAD2L1BP APC APC PLK1 PLK1 TPR TPR BCL7C BCL7C DYNC1LI1 DYNC1LI1 M3YJ43_MUSPF M3YJ43_MUSPF M3YIU0_MUSPF M3YIU0_MUSPF M3YD28_MUSPF M3YD28_MUSPF FBXO5 FBXO5 ANAPC15 ANAPC15 PCID2 PCID2 USP44 USP44 M3Y8U7_MUSPF M3Y8U7_MUSPF ZWILCH ZWILCH RAD21 RAD21 NSMCE2 NSMCE2 RB1 RB1 CDC27 CDC27 CENPE CENPE CDC16 CDC16 M3YAG0_MUSPF M3YAG0_MUSPF TRIP13 TRIP13 AURKB AURKB CDC23 CDC23 KNTC1 KNTC1 BCL7A BCL7A ANAPC5 ANAPC5 ANAPC7 ANAPC7 XRCC3 XRCC3 BUB3 BUB3 KLHL22 KLHL22 ZW10 ZW10 PSMG2 PSMG2 RIOK2 RIOK2 NDC80 NDC80 ATM ATM M3Z7E4_MUSPF M3Z7E4_MUSPF M3Z5C9_MUSPF M3Z5C9_MUSPF M3Z575_MUSPF M3Z575_MUSPF HASPIN HASPIN TTK TTK MAD1L1 MAD1L1 M3Z1P4_MUSPF M3Z1P4_MUSPF MAD2L1 MAD2L1 ANAPC4 ANAPC4 CUL3 CUL3 M3YU40_MUSPF M3YU40_MUSPF CDC6 CDC6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZNF207Zinc finger protein 207. (534 aa)
NEK6NIMA related kinase 6; Belongs to the protein kinase superfamily. (426 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (907 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (307 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (603 aa)
MAD2L1BPMAD2L1 binding protein. (281 aa)
APCAPC regulator of WNT signaling pathway. (2862 aa)
PLK1Serine/threonine-protein kinase PLK. (542 aa)
TPRTranslocated promoter region, nuclear basket protein. (2439 aa)
BCL7CBAF chromatin remodeling complex subunit BCL7C. (217 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (524 aa)
M3YJ43_MUSPFLeucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (339 aa)
M3YIU0_MUSPFRING-type domain-containing protein. (84 aa)
M3YD28_MUSPFUncharacterized protein. (1086 aa)
FBXO5F-box protein 5. (386 aa)
ANAPC15Anaphase promoting complex subunit 15. (132 aa)
PCID2PCI domain containing 2. (390 aa)
USP44Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (711 aa)
M3Y8U7_MUSPFCDT1 domain-containing protein. (347 aa)
ZWILCHZwilch kinetochore protein. (589 aa)
RAD21RAD21 cohesin complex component. (631 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (275 aa)
RB1RB transcriptional corepressor 1. (948 aa)
CDC27Cell division cycle 27. (825 aa)
CENPECentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2814 aa)
CDC16Cell division cycle 16. (605 aa)
M3YAG0_MUSPFBUB1 N-terminal domain-containing protein. (1062 aa)
TRIP13Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (434 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
CDC23Cell division cycle 23. (590 aa)
KNTC1Kinetochore associated 1. (2207 aa)
BCL7ABAF chromatin remodeling complex subunit BCL7A. (201 aa)
ANAPC5Anaphase promoting complex subunit 5. (711 aa)
ANAPC7Anaphase promoting complex subunit 7. (598 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa)
BUB3BUB3 mitotic checkpoint protein. (328 aa)
KLHL22Kelch like family member 22. (634 aa)
ZW10Zw10 kinetochore protein. (779 aa)
PSMG2Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (264 aa)
RIOK2RIO kinase 2. (551 aa)
NDC80NDC80 kinetochore complex component. (642 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
M3Z7E4_MUSPFUncharacterized protein. (1085 aa)
M3Z5C9_MUSPFUBIQUITIN_CONJUGAT_2 domain-containing protein. (179 aa)
M3Z575_MUSPFUBIQUITIN_CONJUGAT_2 domain-containing protein. (179 aa)
HASPINHistone H3 associated protein kinase. (767 aa)
TTKTTK protein kinase. (856 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (737 aa)
M3Z1P4_MUSPFUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (181 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (807 aa)
CUL3Cullin 3; Belongs to the cullin family. (746 aa)
M3YU40_MUSPFUncharacterized protein. (158 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.