(27 nodes) DNA damage response, signal transduction by p53 class mediator network (Mustela putorius)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	ATRX	ATRX chromatin remodeler. (2784 aa)
	NDRG1	N-myc downstream regulated 1. (384 aa)
	BRCA2	BRCA2 DNA repair associated. (3466 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1165 aa)
	MUC1	SEA domain-containing protein. (560 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (794 aa)
	BCL3	BCL3 transcription coactivator. (456 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (452 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (799 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
	PIDD1	P53-induced death domain protein 1. (915 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (125 aa)
	FOXM1	Forkhead box M1. (760 aa)
	PAXIP1	PAX interacting protein 1. (1293 aa)
	FOXO3	Forkhead box O3. (671 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
	CHEK2	Checkpoint kinase 2. (544 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	TFAP4	Transcription factor AP-4. (365 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (453 aa)
	SESN2	Sestrin 2. (479 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	ING4	Inhibitor of growth family member 4. (239 aa)
	PML	Promyelocytic leukemia. (876 aa)
	E2F7	E2F transcription factor 7. (899 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1253 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATRX	TP53	ENSMPUP00000000083	ENSMPUP00000008945	ATRX chromatin remodeler.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.632
BRCA2	CHEK2	ENSMPUP00000001928	ENSMPUP00000013463	BRCA2 DNA repair associated.	Checkpoint kinase 2.	0.787
BRCA2	KAT5	ENSMPUP00000001928	ENSMPUP00000011528	BRCA2 DNA repair associated.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.400
BRCA2	TP53	ENSMPUP00000001928	ENSMPUP00000008945	BRCA2 DNA repair associated.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.872
CASP2	MDM2	ENSMPUP00000006916	ENSMPUP00000017394	Caspase 2; Belongs to the peptidase C14A family.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.413
CASP2	PIDD1	ENSMPUP00000006916	ENSMPUP00000008961	Caspase 2; Belongs to the peptidase C14A family.	P53-induced death domain protein 1.	0.975
CASP2	TP53	ENSMPUP00000006916	ENSMPUP00000008945	Caspase 2; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.592
CDKN1A	FOXO3	ENSMPUP00000014105	ENSMPUP00000009773	Cyclin dependent kinase inhibitor 1A.	Forkhead box O3.	0.798
CDKN1A	MDM2	ENSMPUP00000014105	ENSMPUP00000017394	Cyclin dependent kinase inhibitor 1A.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.843
CDKN1A	SESN2	ENSMPUP00000014105	ENSMPUP00000015424	Cyclin dependent kinase inhibitor 1A.	Sestrin 2.	0.410
CDKN1A	TFAP4	ENSMPUP00000014105	ENSMPUP00000014912	Cyclin dependent kinase inhibitor 1A.	Transcription factor AP-4.	0.932
CDKN1A	TP53	ENSMPUP00000014105	ENSMPUP00000008945	Cyclin dependent kinase inhibitor 1A.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.995
CHEK2	BRCA2	ENSMPUP00000013463	ENSMPUP00000001928	Checkpoint kinase 2.	BRCA2 DNA repair associated.	0.787
CHEK2	KAT5	ENSMPUP00000013463	ENSMPUP00000011528	Checkpoint kinase 2.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.422
CHEK2	MDM2	ENSMPUP00000013463	ENSMPUP00000017394	Checkpoint kinase 2.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.799
CHEK2	PAXIP1	ENSMPUP00000013463	ENSMPUP00000009354	Checkpoint kinase 2.	PAX interacting protein 1.	0.535
CHEK2	PPM1D	ENSMPUP00000013463	ENSMPUP00000014999	Checkpoint kinase 2.	Protein phosphatase, Mg2+/Mn2+ dependent 1D.	0.524
CHEK2	TP53	ENSMPUP00000013463	ENSMPUP00000008945	Checkpoint kinase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.984
E2F7	FOXM1	ENSMPUP00000017358	ENSMPUP00000009332	E2F transcription factor 7.	Forkhead box M1.	0.526
E2F7	TP53	ENSMPUP00000017358	ENSMPUP00000008945	E2F transcription factor 7.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.452