STRINGSTRING
CDK1 CDK1 ARL8A ARL8A CHMP2B CHMP2B KIF14 KIF14 EXOC3 EXOC3 MICAL1 MICAL1 ARF6 ARF6 MAP10 MAP10 RHOB RHOB NUP62 NUP62 KIF20A KIF20A AGBL5 AGBL5 MAPRE3 MAPRE3 M3YCZ1_MUSPF M3YCZ1_MUSPF CENPE CENPE PIK3CB PIK3CB GEM GEM TBCK TBCK EML4 EML4 CAPG CAPG UVRAG UVRAG ZFYVE19 ZFYVE19 HEPACAM2 HEPACAM2 CHMP2A CHMP2A APC2 APC2 AURKB AURKB MYH10 MYH10 USP8 USP8 USP50 USP50 IST1 IST1 SEPTIN7 SEPTIN7 ANLN ANLN CRMP1 CRMP1 ERH ERH M3Y7C1_MUSPF M3Y7C1_MUSPF CHMP1A CHMP1A CEP126 CEP126 ZFYVE26 ZFYVE26 PTCH1 PTCH1 KEAP1 KEAP1 BCL3 BCL3 MARK4 MARK4 CHMP4A CHMP4A M3Y3A6_MUSPF M3Y3A6_MUSPF MDP1 MDP1 DTNBP1 DTNBP1 BIRC6 BIRC6 SPAST SPAST RHOC RHOC SH3GLB1 SH3GLB1 PKN2 PKN2 MTCL1 MTCL1 M3Y000_MUSPF M3Y000_MUSPF KATNAL1 KATNAL1 DCTN3 DCTN3 KIF4A KIF4A M3XYN0_MUSPF M3XYN0_MUSPF CHMP5 CHMP5 M3XXC5_MUSPF M3XXC5_MUSPF ANXA11 ANXA11 CHMP7 CHMP7 GNAI3 GNAI3 CYLD CYLD PSRC1 PSRC1 PKN1 PKN1 CENPF CENPF ABRAXAS2 ABRAXAS2 PPP1CC PPP1CC AGAP2 AGAP2 NEXMIF NEXMIF CEP44 CEP44 SPART SPART VPS37B VPS37B CHMP4C CHMP4C CENPC CENPC SEPTIN6 SEPTIN6 RACK1 RACK1 PIK3C3 PIK3C3 RAD21 RAD21 RALB RALB RAB8B RAB8B USP3 USP3 MAK MAK CTNND1 CTNND1 SEPTIN2 SEPTIN2 RASGEF1B RASGEF1B CDCA8 CDCA8 RAB11FIP4 RAB11FIP4 PIN1 PIN1 RACGAP1 RACGAP1 C6orf89 C6orf89 RNF8 RNF8 INCENP INCENP HSPA5 HSPA5 EML3 EML3 KLHDC8B KLHDC8B RHOA RHOA CCDC69 CCDC69 LYRM1 LYRM1 TTC28 TTC28 M3YQ61_MUSPF M3YQ61_MUSPF FLCN FLCN M3Z5K9_MUSPF M3Z5K9_MUSPF CHAMP1 CHAMP1 GNAI1 GNAI1 MPLKIP MPLKIP MICAL3 MICAL3 KATNA1 KATNA1 YPEL5 YPEL5 SIRT2 SIRT2 CPEB3 CPEB3 EXOC6 EXOC6 CEP55 CEP55 ECT2 ECT2 ARL8B ARL8B LZTS2 LZTS2 ARL3 ARL3 GNL3 GNL3 CTDP1 CTDP1 VPS4B VPS4B RCC2 RCC2 M3YXA3_MUSPF M3YXA3_MUSPF RAB8A RAB8A RAB11FIP3 RAB11FIP3 M3YX33_MUSPF M3YX33_MUSPF ALKBH4 ALKBH4 C9orf72 C9orf72 NEK2 NEK2 CLIC4 CLIC4 SCCPDH SCCPDH CCDC124 CCDC124 HNRNPU HNRNPU PRC1 PRC1 NUDC NUDC IQGAP1 IQGAP1 SEPTIN12 SEPTIN12 AFMID AFMID BIRC5 BIRC5 GNAI2 GNAI2 SVIL SVIL ANKRD54 ANKRD54 URB2 URB2 PLK1 PLK1 TXNDC9 TXNDC9 KLHDC8A KLHDC8A CHMP6 CHMP6 M3YK20_MUSPF M3YK20_MUSPF NAT10 NAT10 ENTR1 ENTR1 M3YIK9_MUSPF M3YIK9_MUSPF MITD1 MITD1 LOC106004699 LOC106004699
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
ARL8AADP ribosylation factor like GTPase 8A; Belongs to the small GTPase superfamily. Arf family. (159 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1662 aa)
EXOC3Exocyst complex component 3. (745 aa)
MICAL1Microtubule associated monooxygenase, calponin and LIM domain containing 1. (1076 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
MAP10Microtubule associated protein 10. (848 aa)
RHOBRas homolog family member B. (196 aa)
NUP62Nucleoporin 62. (527 aa)
KIF20AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (887 aa)
AGBL5ATP/GTP binding protein like 5. (815 aa)
MAPRE3Microtubule associated protein RP/EB family member 3. (294 aa)
M3YCZ1_MUSPFUncharacterized protein. (223 aa)
CENPECentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2814 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
TBCKTBC1 domain containing kinase. (893 aa)
EML4EMAP like 4. (992 aa)
CAPGCapping actin protein, gelsolin like. (349 aa)
UVRAGUV radiation resistance associated. (660 aa)
ZFYVE19Zinc finger FYVE-type containing 19. (399 aa)
HEPACAM2HEPACAM family member 2. (463 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
APC2APC regulator of WNT signaling pathway 2. (2481 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1997 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1116 aa)
USP50Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (376 aa)
IST1IST1 factor associated with ESCRT-III. (354 aa)
SEPTIN7Septin 7; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (436 aa)
ANLNAnillin actin binding protein. (1124 aa)
CRMP1Collapsin response mediator protein 1. (674 aa)
ERHERH mRNA splicing and mitosis factor. (156 aa)
M3Y7C1_MUSPFUncharacterized protein; Belongs to the AAA ATPase family. (437 aa)
CHMP1ACharged multivesicular body protein 1A. (196 aa)
CEP126Centrosomal protein 126. (1077 aa)
ZFYVE26Zinc finger FYVE-type containing 26. (2539 aa)
PTCH1Patched 1. (1386 aa)
KEAP1Kelch like ECH associated protein 1. (620 aa)
BCL3BCL3 transcription coactivator. (456 aa)
MARK4Microtubule affinity regulating kinase 4. (688 aa)
CHMP4ACharged multivesicular body protein 4A. (266 aa)
M3Y3A6_MUSPFUncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (853 aa)
MDP1Uncharacterized protein. (164 aa)
DTNBP1Dystrobrevin binding protein 1. (349 aa)
BIRC6Baculoviral IAP repeat containing 6. (4785 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (616 aa)
RHOCRas homolog family member C. (193 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (401 aa)
PKN2Protein kinase N2. (983 aa)
MTCL1Microtubule crosslinking factor 1. (1686 aa)
M3Y000_MUSPFANK_REP_REGION domain-containing protein. (258 aa)
KATNAL1Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...] (490 aa)
DCTN3Dynactin subunit 3. (186 aa)
KIF4AKinesin family member 4A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1239 aa)
M3XYN0_MUSPFUncharacterized protein. (192 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
M3XXC5_MUSPFNsp1_C domain-containing protein. (267 aa)
ANXA11Annexin. (505 aa)
CHMP7Charged multivesicular body protein 7. (398 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
PSRC1Proline and serine rich coiled-coil 1. (327 aa)
PKN1Protein kinase N1. (950 aa)
CENPFCentromere protein F. (3110 aa)
ABRAXAS2Abraxas 2, BRISC complex subunit. (418 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1172 aa)
NEXMIFNeurite extension and migration factor. (1513 aa)
CEP44Centrosomal protein 44. (388 aa)
SPARTSpartin. (732 aa)
VPS37BVPS37B subunit of ESCRT-I. (327 aa)
CHMP4CCharged multivesicular body protein 4C. (237 aa)
CENPCCentromere protein C. (947 aa)
SEPTIN6Septin 6; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (427 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (317 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
RAD21RAD21 cohesin complex component. (631 aa)
RALBRAS like proto-oncogene B. (206 aa)
RAB8BRAB8B, member RAS oncogene family. (207 aa)
USP3Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (435 aa)
MAKMale germ cell associated kinase. (587 aa)
CTNND1Catenin delta 1. (967 aa)
SEPTIN2Septin 2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (361 aa)
RASGEF1BRasGEF domain family member 1B. (472 aa)
CDCA8Cell division cycle associated 8. (280 aa)
RAB11FIP4RAB11 family interacting protein 4. (544 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (162 aa)
RACGAP1Rac GTPase activating protein 1. (631 aa)
C6orf89Chromosome 6 open reading frame 89. (355 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa)
INCENPInner centromere protein. (890 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
EML3EMAP like 3. (897 aa)
KLHDC8BKelch domain containing 8B. (354 aa)
RHOARas homolog family member A. (193 aa)
CCDC69Coiled-coil domain containing 69. (294 aa)
LYRM1LYR motif containing 1; Belongs to the complex I LYR family. (122 aa)
TTC28Tetratricopeptide repeat domain 28. (2360 aa)
M3YQ61_MUSPFTPR_REGION domain-containing protein. (150 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
M3Z5K9_MUSPFGFA domain-containing protein. (261 aa)
CHAMP1Chromosome alignment maintaining phosphoprotein 1. (814 aa)
GNAI1G protein subunit alpha i1. (354 aa)
MPLKIPM-phase specific PLK1 interacting protein. (179 aa)
MICAL3Microtubule associated monooxygenase, calponin and LIM domain containing 3. (1938 aa)
KATNA1Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (491 aa)
YPEL5Protein yippee-like; Belongs to the yippee family. (121 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (412 aa)
CPEB3Cytoplasmic polyadenylation element binding protein 3. (692 aa)
EXOC6Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (803 aa)
CEP55Centrosomal protein 55. (463 aa)
ECT2Epithelial cell transforming 2. (914 aa)
ARL8BADP ribosylation factor like GTPase 8B; Belongs to the small GTPase superfamily. Arf family. (186 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa)
ARL3ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family. (182 aa)
GNL3G protein nucleolar 3. (546 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (759 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (422 aa)
RCC2Regulator of chromosome condensation 2. (427 aa)
M3YXA3_MUSPFUncharacterized protein. (1700 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
RAB11FIP3RAB11 family interacting protein 3. (647 aa)
M3YX33_MUSPFUncharacterized protein. (191 aa)
ALKBH4AlkB homolog 4, lysine demethylase. (308 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
NEK2NIMA related kinase 2. (444 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
SCCPDHSaccharopine dehydrogenase (putative). (429 aa)
CCDC124Coiled-coil domain containing 124. (223 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (592 aa)
PRC1Protein regulator of cytokinesis 1. (563 aa)
NUDCNuclear distribution C, dynein complex regulator. (332 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1627 aa)
SEPTIN12Septin 12; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (359 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (307 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
GNAI2G protein subunit alpha i2. (355 aa)
SVILSupervillin. (2245 aa)
ANKRD54Ankyrin repeat domain 54. (299 aa)
URB2URB2 ribosome biogenesis homolog. (1520 aa)
PLK1Serine/threonine-protein kinase PLK. (542 aa)
TXNDC9Thioredoxin domain containing 9. (226 aa)
KLHDC8AKelch domain containing 8A. (350 aa)
CHMP6Charged multivesicular body protein 6. (199 aa)
M3YK20_MUSPFWD_REPEATS_REGION domain-containing protein. (237 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
ENTR1Endosome associated trafficking regulator 1. (376 aa)
M3YIK9_MUSPFUncharacterized protein. (1827 aa)
MITD1Microtubule interacting and trafficking domain containing 1. (249 aa)
LOC106004699Uncharacterized protein. (178 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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