(45 nodes) Pancreas development network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (602 aa)
	PAX4	Paired box 4. (351 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (790 aa)
	GIPR	Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
	IGF2	Insulin like growth factor 2. (192 aa)
	GATA6	GATA binding protein 6. (482 aa)
	RBM4	RNA binding motif protein 4. (365 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	PDX1	Pancreatic and duodenal homeobox 1. (283 aa)
	ALDH1A2	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
	SIDT2	SID1 transmembrane family member 2. (832 aa)
	HES1	Hes family bHLH transcription factor 1. (283 aa)
	NPHP3	TPR_REGION domain-containing protein. (1331 aa)
	NKX6-1	NK6 homeobox 1. (355 aa)
	PAX6	Paired box 6. (436 aa)
	CCDC40	Coiled-coil domain containing 40. (1142 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	RFX6	Regulatory factor X6. (928 aa)
	SOX9	SRY-box transcription factor 9. (522 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	HNF1B	HNF1 homeobox B. (558 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (531 aa)
	GIP	Gastric inhibitory polypeptide. (144 aa)
	ILDR2	Immunoglobulin like domain containing receptor 2. (426 aa)
	SRP54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	ONECUT2	One cut domain family member. (395 aa)
	IHH	Indian hedgehog signaling molecule. (384 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (443 aa)
	BHLHA15	Basic helix-loop-helix family member a15. (187 aa)
	M3YED9_MUSPF	Homeobox domain-containing protein. (242 aa)
	M3YE59_MUSPF	HH_signal domain-containing protein. (290 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1065 aa)
	DNAAF1	Dynein assembly factor 1, axonemal. (657 aa)
	ANXA1	Annexin. (345 aa)
	M3YBQ0_MUSPF	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (137 aa)
	FOXF1	Forkhead box F1. (321 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	HNF1A	HNF1 homeobox A. (633 aa)
	BMP5	Bone morphogenetic protein 5. (454 aa)
	M3XU21_MUSPF	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (129 aa)
	ZIC3	Zic family member 3. (473 aa)
	FOXA2	Forkhead box A2. (457 aa)
	GDF11	Growth differentiation factor 11. (404 aa)
	BMP6	Bone morphogenetic protein 6. (426 aa)
	NKX3-2	NK3 homeobox 2. (331 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BHLHA15	HNF1B	ENSMPUP00000019968	ENSMPUP00000014894	Basic helix-loop-helix family member a15.	HNF1 homeobox B.	0.534
BMP4	BMP5	ENSMPUP00000005423	ENSMPUP00000002775	Bone morphogenetic protein 4.	Bone morphogenetic protein 5.	0.651
BMP4	BMP6	ENSMPUP00000005423	ENSMPUP00000000577	Bone morphogenetic protein 4.	Bone morphogenetic protein 6.	0.965
BMP4	FGF10	ENSMPUP00000005423	ENSMPUP00000014301	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.818
BMP4	FOXA2	ENSMPUP00000005423	ENSMPUP00000001155	Bone morphogenetic protein 4.	Forkhead box A2.	0.777
BMP4	FOXF1	ENSMPUP00000005423	ENSMPUP00000008550	Bone morphogenetic protein 4.	Forkhead box F1.	0.471
BMP4	GATA6	ENSMPUP00000005423	ENSMPUP00000005576	Bone morphogenetic protein 4.	GATA binding protein 6.	0.600
BMP4	IHH	ENSMPUP00000005423	ENSMPUP00000016454	Bone morphogenetic protein 4.	Indian hedgehog signaling molecule.	0.663
BMP4	M3YE59_MUSPF	ENSMPUP00000005423	ENSMPUP00000009616	Bone morphogenetic protein 4.	HH_signal domain-containing protein.	0.663
BMP4	PAX6	ENSMPUP00000005423	ENSMPUP00000011203	Bone morphogenetic protein 4.	Paired box 6.	0.526
BMP4	SOX9	ENSMPUP00000005423	ENSMPUP00000014195	Bone morphogenetic protein 4.	SRY-box transcription factor 9.	0.589
BMP5	BMP4	ENSMPUP00000002775	ENSMPUP00000005423	Bone morphogenetic protein 5.	Bone morphogenetic protein 4.	0.651
BMP5	IHH	ENSMPUP00000002775	ENSMPUP00000016454	Bone morphogenetic protein 5.	Indian hedgehog signaling molecule.	0.404
BMP5	M3YE59_MUSPF	ENSMPUP00000002775	ENSMPUP00000009616	Bone morphogenetic protein 5.	HH_signal domain-containing protein.	0.404
BMP6	BMP4	ENSMPUP00000000577	ENSMPUP00000005423	Bone morphogenetic protein 6.	Bone morphogenetic protein 4.	0.965
BMP6	SOX9	ENSMPUP00000000577	ENSMPUP00000014195	Bone morphogenetic protein 6.	SRY-box transcription factor 9.	0.504
CCDC40	DNAAF1	ENSMPUP00000012134	ENSMPUP00000008854	Coiled-coil domain containing 40.	Dynein assembly factor 1, axonemal.	0.612
CCDC40	NPHP3	ENSMPUP00000012134	ENSMPUP00000009744	Coiled-coil domain containing 40.	TPR_REGION domain-containing protein.	0.459
DLL1	HES1	ENSMPUP00000006989	ENSMPUP00000003614	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 1.	0.546
DNAAF1	CCDC40	ENSMPUP00000008854	ENSMPUP00000012134	Dynein assembly factor 1, axonemal.	Coiled-coil domain containing 40.	0.612