(29 nodes) Positive regulation of interleukin-2 production network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD83	CD83 molecule. (199 aa)
	M3XNV3_MUSPF	Uncharacterized protein. (93 aa)
	M3XNV5_MUSPF	PDE4_UCR domain-containing protein. (232 aa)
	PDE4B	Phosphodiesterase. (544 aa)
	VTCN1	V-set domain containing T cell activation inhibitor 1. (318 aa)
	GLMN	Glomulin, FKBP associated protein. (600 aa)
	CD3E	CD3 epsilon antigen. (186 aa)
	STOML2	Stomatin like 2. (356 aa)
	PRKD2	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
	CLEC7A	C-type lectin domain containing 7A. (248 aa)
	CD28	CD28 molecule. (255 aa)
	PDE4D	Phosphodiesterase. (673 aa)
	IRF4	Interferon regulatory factor 4. (451 aa)
	ANXA1	Annexin. (345 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	RPS3	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
	M3YDY7_MUSPF	Uncharacterized protein. (257 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1298 aa)
	STAT5A	Signal transducer and activator of transcription. (794 aa)
	STAT5B	Signal transducer and activator of transcription. (691 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	ABL1	Tyrosine-protein kinase. (1150 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	MALT1	MALT1 paracaspase. (716 aa)
	SASH3	SAM and SH3 domain containing 3. (380 aa)
	CARD11	Caspase recruitment domain family member 11. (1153 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	STAT5A	ENSMPUP00000012584	ENSMPUP00000010440	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.943
ABL1	STAT5B	ENSMPUP00000012584	ENSMPUP00000010450	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.943
CARD11	MALT1	ENSMPUP00000017839	ENSMPUP00000016372	Caspase recruitment domain family member 11.	MALT1 paracaspase.	0.988
CARD11	MAP3K7	ENSMPUP00000017839	ENSMPUP00000009014	Caspase recruitment domain family member 11.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.709
CARD11	PRKCQ	ENSMPUP00000017839	ENSMPUP00000016259	Caspase recruitment domain family member 11.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.981
CARD11	RIPK2	ENSMPUP00000017839	ENSMPUP00000010871	Caspase recruitment domain family member 11.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.546
CARD11	TRAF6	ENSMPUP00000017839	ENSMPUP00000011691	Caspase recruitment domain family member 11.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.717
CD28	PRKCQ	ENSMPUP00000000415	ENSMPUP00000016259	CD28 molecule.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.958
CD28	PTPRC	ENSMPUP00000000415	ENSMPUP00000010371	CD28 molecule.	Protein tyrosine phosphatase receptor type C.	0.430
CD28	VTCN1	ENSMPUP00000000415	ENSMPUP00000001577	CD28 molecule.	V-set domain containing T cell activation inhibitor 1.	0.485
CD3E	MAP3K7	ENSMPUP00000004435	ENSMPUP00000009014	CD3 epsilon antigen.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.404
CD3E	PRKCQ	ENSMPUP00000004435	ENSMPUP00000016259	CD3 epsilon antigen.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.424
CD3E	PTPRC	ENSMPUP00000004435	ENSMPUP00000010371	CD3 epsilon antigen.	Protein tyrosine phosphatase receptor type C.	0.669
CD3E	RIPK2	ENSMPUP00000004435	ENSMPUP00000010871	CD3 epsilon antigen.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.404
IRF4	TRAF6	ENSMPUP00000007790	ENSMPUP00000011691	Interferon regulatory factor 4.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.609
M3XNV3_MUSPF	M3XNV5_MUSPF	ENSMPUP00000000753	ENSMPUP00000000755	Uncharacterized protein.	PDE4_UCR domain-containing protein.	0.900
M3XNV3_MUSPF	PDE4B	ENSMPUP00000000753	ENSMPUP00000000758	Uncharacterized protein.	Phosphodiesterase.	0.899
M3XNV3_MUSPF	PDE4D	ENSMPUP00000000753	ENSMPUP00000007341	Uncharacterized protein.	Phosphodiesterase.	0.975
M3XNV5_MUSPF	M3XNV3_MUSPF	ENSMPUP00000000755	ENSMPUP00000000753	PDE4_UCR domain-containing protein.	Uncharacterized protein.	0.900
M3XNV5_MUSPF	PDE4B	ENSMPUP00000000755	ENSMPUP00000000758	PDE4_UCR domain-containing protein.	Phosphodiesterase.	0.899