(24 nodes) Negative regulation of intracellular steroid hormone receptor signaling pathway network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CNOT1	CCR4-NOT transcription complex subunit 1. (2376 aa)
	PIAS2	Protein inhibitor of activated STAT 2. (719 aa)
	NCOR2	Nuclear receptor corepressor 2. (2525 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (474 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (586 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	ZBTB7A	Zinc finger and BTB domain containing 7A. (550 aa)
	KANK2	KN motif and ankyrin repeat domains 2. (851 aa)
	CRY2	Cryptochrome circadian regulator 2. (594 aa)
	M3Y377_MUSPF	NTR domain-containing protein. (233 aa)
	FOXH1	Forkhead box H1. (398 aa)
	VPS18	VPS18 core subunit of CORVET and HOPS complexes. (973 aa)
	NCOR1	Nuclear receptor corepressor 1. (2510 aa)
	SIRT1	Sirtuin 1. (557 aa)
	CRY1	Cryptochrome circadian regulator 1. (587 aa)
	ZNF366	Zinc finger protein 366. (659 aa)
	DAB2	Disabled-like protein 2, mitogen-responsive phosphoprotein. (769 aa)
	TCF21	Transcription factor 21. (179 aa)
	PHB	Prohibitin. (272 aa)
	NR0B2	Nuclear receptor subfamily 0 group B member 2. (279 aa)
	CNOT9	CCR4-NOT transcription complex subunit 9. (299 aa)
	PHB2	Prohibitin. (299 aa)
	FOXP1	Forkhead box P1. (676 aa)
	CNOT2	CCR4-NOT transcription complex subunit 2. (540 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNOT1	CNOT2	ENSMPUP00000004790	ENSMPUP00000017384	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 2.	0.999
CNOT1	CNOT9	ENSMPUP00000004790	ENSMPUP00000016434	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 9.	0.999
CNOT2	CNOT1	ENSMPUP00000017384	ENSMPUP00000004790	CCR4-NOT transcription complex subunit 2.	CCR4-NOT transcription complex subunit 1.	0.999
CNOT2	CNOT9	ENSMPUP00000017384	ENSMPUP00000016434	CCR4-NOT transcription complex subunit 2.	CCR4-NOT transcription complex subunit 9.	0.998
CNOT9	CNOT1	ENSMPUP00000016434	ENSMPUP00000004790	CCR4-NOT transcription complex subunit 9.	CCR4-NOT transcription complex subunit 1.	0.999
CNOT9	CNOT2	ENSMPUP00000016434	ENSMPUP00000017384	CCR4-NOT transcription complex subunit 9.	CCR4-NOT transcription complex subunit 2.	0.998
CRY1	CRY2	ENSMPUP00000012065	ENSMPUP00000005738	Cryptochrome circadian regulator 1.	Cryptochrome circadian regulator 2.	0.996
CRY2	CRY1	ENSMPUP00000005738	ENSMPUP00000012065	Cryptochrome circadian regulator 2.	Cryptochrome circadian regulator 1.	0.996
FOXH1	NODAL	ENSMPUP00000006078	ENSMPUP00000004259	Forkhead box H1.	Nodal growth differentiation factor.	0.531
NCOR1	NCOR2	ENSMPUP00000010116	ENSMPUP00000001405	Nuclear receptor corepressor 1.	Nuclear receptor corepressor 2.	0.939
NCOR1	NR0B1	ENSMPUP00000010116	ENSMPUP00000002631	Nuclear receptor corepressor 1.	Nuclear receptor subfamily 0 group B member 1.	0.553
NCOR1	NR0B2	ENSMPUP00000010116	ENSMPUP00000015554	Nuclear receptor corepressor 1.	Nuclear receptor subfamily 0 group B member 2.	0.523
NCOR1	SIRT1	ENSMPUP00000010116	ENSMPUP00000011868	Nuclear receptor corepressor 1.	Sirtuin 1.	0.684
NCOR1	ZBTB7A	ENSMPUP00000010116	ENSMPUP00000004666	Nuclear receptor corepressor 1.	Zinc finger and BTB domain containing 7A.	0.429
NCOR2	NCOR1	ENSMPUP00000001405	ENSMPUP00000010116	Nuclear receptor corepressor 2.	Nuclear receptor corepressor 1.	0.939
NCOR2	NR0B1	ENSMPUP00000001405	ENSMPUP00000002631	Nuclear receptor corepressor 2.	Nuclear receptor subfamily 0 group B member 1.	0.685
NCOR2	NR0B2	ENSMPUP00000001405	ENSMPUP00000015554	Nuclear receptor corepressor 2.	Nuclear receptor subfamily 0 group B member 2.	0.523
NCOR2	PHB2	ENSMPUP00000001405	ENSMPUP00000016660	Nuclear receptor corepressor 2.	Prohibitin.	0.613
NCOR2	SIRT1	ENSMPUP00000001405	ENSMPUP00000011868	Nuclear receptor corepressor 2.	Sirtuin 1.	0.676
NODAL	FOXH1	ENSMPUP00000004259	ENSMPUP00000006078	Nodal growth differentiation factor.	Forkhead box H1.	0.531