node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSF1R | M3XWH1_MUSPF | ENSMPUP00000013894 | ENSMPUP00000003421 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Uncharacterized protein. | 0.548 |
CSF1R | TMEM119 | ENSMPUP00000013894 | ENSMPUP00000003387 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Transmembrane protein 119. | 0.784 |
CSF1R | TNFSF11 | ENSMPUP00000013894 | ENSMPUP00000001699 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | TNF superfamily member 11; Belongs to the tumor necrosis factor family. | 0.449 |
DCSTAMP | TNFRSF11A | ENSMPUP00000014981 | ENSMPUP00000016404 | Dendrocyte expressed seven transmembrane protein. | TNF receptor superfamily member 11a. | 0.489 |
DEF8 | INPP5D | ENSMPUP00000006922 | ENSMPUP00000005251 | Differentially expressed in FDCP 8 homolog. | Inositol polyphosphate-5-phosphatase D. | 0.622 |
FSHR | LEP | ENSMPUP00000010835 | ENSMPUP00000006474 | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.431 |
GPNMB | TMEM119 | ENSMPUP00000013437 | ENSMPUP00000003387 | Glycoprotein nmb. | Transmembrane protein 119. | 0.622 |
HAND2 | LTBP3 | ENSMPUP00000001892 | ENSMPUP00000011851 | Heart and neural crest derivatives expressed 2. | Latent transforming growth factor beta binding protein 3. | 0.529 |
IAPP | LEP | ENSMPUP00000011194 | ENSMPUP00000006474 | Islet amyloid polypeptide. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.438 |
INPP5D | DEF8 | ENSMPUP00000005251 | ENSMPUP00000006922 | Inositol polyphosphate-5-phosphatase D. | Differentially expressed in FDCP 8 homolog. | 0.622 |
LEP | FSHR | ENSMPUP00000006474 | ENSMPUP00000010835 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | 0.431 |
LEP | IAPP | ENSMPUP00000006474 | ENSMPUP00000011194 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Islet amyloid polypeptide. | 0.438 |
LEP | LEPR | ENSMPUP00000006474 | ENSMPUP00000000731 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Leptin receptor. | 0.999 |
LEP | TP53 | ENSMPUP00000006474 | ENSMPUP00000008945 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.619 |
LEPR | LEP | ENSMPUP00000000731 | ENSMPUP00000006474 | Leptin receptor. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.999 |
LTBP3 | HAND2 | ENSMPUP00000011851 | ENSMPUP00000001892 | Latent transforming growth factor beta binding protein 3. | Heart and neural crest derivatives expressed 2. | 0.529 |
M3XWH1_MUSPF | CSF1R | ENSMPUP00000003421 | ENSMPUP00000013894 | Uncharacterized protein. | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.548 |
M3XWH1_MUSPF | M3Y653_MUSPF | ENSMPUP00000003421 | ENSMPUP00000006804 | Uncharacterized protein. | Protein kinase domain-containing protein. | 0.963 |
M3Y653_MUSPF | M3XWH1_MUSPF | ENSMPUP00000006804 | ENSMPUP00000003421 | Protein kinase domain-containing protein. | Uncharacterized protein. | 0.963 |
NF1 | TP53 | ENSMPUP00000014319 | ENSMPUP00000008945 | Neurofibromin 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.602 |