STRINGSTRING
NELFE NELFE PWWP2B PWWP2B M3Z4Q8_MUSPF M3Z4Q8_MUSPF CDK13 CDK13 WDR43 WDR43 LDB1 LDB1 ZMYND11 ZMYND11 BRD4 BRD4 AXIN1 AXIN1 HNRNPU HNRNPU ELL ELL SUPT4H1 SUPT4H1 NELFB NELFB CCNT1 CCNT1 SUPT6H SUPT6H RNF8 RNF8 RECQL5 RECQL5 MED8 MED8 CDK9 CDK9 PWWP2A PWWP2A NELFA NELFA ELL3 ELL3 USP10 USP10 G9K828_MUSPF G9K828_MUSPF LEO1 LEO1 EZH2 EZH2 NELFCD NELFCD GTF2F1 GTF2F1 EAF2 EAF2 CDC73 CDC73 ELL2 ELL2 RNF168 RNF168 M3XV89_MUSPF M3XV89_MUSPF EAF1 EAF1 M3XPM1_MUSPF M3XPM1_MUSPF M3XN02_MUSPF M3XN02_MUSPF BTBD18 BTBD18 SUPT16H SUPT16H
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NELFENegative elongation factor complex member E. (389 aa)
PWWP2BPWWP domain containing 2B. (494 aa)
M3Z4Q8_MUSPFUncharacterized protein. (286 aa)
CDK13Cyclin dependent kinase 13. (1145 aa)
WDR43WD repeat domain 43. (682 aa)
LDB1LIM domain binding 1. (411 aa)
ZMYND11Zinc finger MYND-type containing 11. (636 aa)
BRD4Bromodomain containing 4. (1420 aa)
AXIN1Axin 1. (862 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (592 aa)
ELLElongation factor for RNA polymerase II. (613 aa)
SUPT4H1Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family. (120 aa)
NELFBNegative elongation factor complex member B. (492 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (727 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (986 aa)
MED8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (269 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
PWWP2APWWP domain containing 2A. (755 aa)
NELFANegative elongation factor complex member A. (532 aa)
ELL3Elongation factor for RNA polymerase II 3. (396 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (799 aa)
G9K828_MUSPFSenescence downregulated leo1-like protein. (115 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (664 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (753 aa)
NELFCDNegative elongation factor complex member C/D. (575 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (517 aa)
EAF2ELL associated factor 2. (264 aa)
CDC73Cell division cycle 73. (531 aa)
ELL2Elongation factor for RNA polymerase II 2. (641 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (572 aa)
M3XV89_MUSPFUncharacterized protein; Belongs to the cyclin family. (501 aa)
EAF1ELL associated factor 1. (268 aa)
M3XPM1_MUSPFUncharacterized protein. (286 aa)
M3XN02_MUSPFUncharacterized protein. (632 aa)
BTBD18BTB domain containing 18. (727 aa)
SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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