(21 nodes) Response to type I interferon network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	STAT1	Signal transducer and activator of transcription. (750 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (696 aa)
	IRF7	Interferon regulatory factor 7. (473 aa)
	SHFL	Shiftless antiviral inhibitor of ribosomal frameshifting. (290 aa)
	M3Y526_MUSPF	Uncharacterized protein. (466 aa)
	SMPD1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	IRF3	Interferon regulatory factor 3. (421 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
	STAT2	Signal transducer and activator of transcription. (848 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (560 aa)
	M3XQ69_MUSPF	Uncharacterized protein. (517 aa)
	IFNB1	Interferon beta. (186 aa)
	M3YUX6_MUSPF	Uncharacterized protein. (497 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2564 aa)
	ISG15	ISG15 ubiquitin like modifier. (184 aa)
	TREX1	Three prime repair exonuclease 1. (313 aa)
	TRIM56	Tripartite motif containing 56. (771 aa)
	CH25H	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (270 aa)
	M3Z8Z8_MUSPF	Uncharacterized protein. (477 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (719 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IFNAR1	IFNB1	ENSMPUP00000001254	ENSMPUP00000019400	Interferon alpha and beta receptor subunit 1.	Interferon beta.	0.996
IFNAR1	IRF3	ENSMPUP00000001254	ENSMPUP00000002449	Interferon alpha and beta receptor subunit 1.	Interferon regulatory factor 3.	0.794
IFNAR1	IRF7	ENSMPUP00000001254	ENSMPUP00000008775	Interferon alpha and beta receptor subunit 1.	Interferon regulatory factor 7.	0.669
IFNAR1	ISG15	ENSMPUP00000001254	ENSMPUP00000013820	Interferon alpha and beta receptor subunit 1.	ISG15 ubiquitin like modifier.	0.675
IFNAR1	M3XQ69_MUSPF	ENSMPUP00000001254	ENSMPUP00000001219	Interferon alpha and beta receptor subunit 1.	Uncharacterized protein.	0.999
IFNAR1	M3Y526_MUSPF	ENSMPUP00000001254	ENSMPUP00000006427	Interferon alpha and beta receptor subunit 1.	Uncharacterized protein.	0.474
IFNAR1	M3Z8Z8_MUSPF	ENSMPUP00000001254	ENSMPUP00000020062	Interferon alpha and beta receptor subunit 1.	Uncharacterized protein.	0.474
IFNAR1	MYD88	ENSMPUP00000001254	ENSMPUP00000002726	Interferon alpha and beta receptor subunit 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.533
IFNAR1	STAT1	ENSMPUP00000001254	ENSMPUP00000012436	Interferon alpha and beta receptor subunit 1.	Signal transducer and activator of transcription.	0.989
IFNAR1	STAT2	ENSMPUP00000001254	ENSMPUP00000001419	Interferon alpha and beta receptor subunit 1.	Signal transducer and activator of transcription.	0.989
IFNB1	IFNAR1	ENSMPUP00000019400	ENSMPUP00000001254	Interferon beta.	Interferon alpha and beta receptor subunit 1.	0.996
IFNB1	IKBKE	ENSMPUP00000019400	ENSMPUP00000011981	Interferon beta.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.410
IFNB1	IRF3	ENSMPUP00000019400	ENSMPUP00000002449	Interferon beta.	Interferon regulatory factor 3.	0.974
IFNB1	IRF7	ENSMPUP00000019400	ENSMPUP00000008775	Interferon beta.	Interferon regulatory factor 7.	0.932
IFNB1	ISG15	ENSMPUP00000019400	ENSMPUP00000013820	Interferon beta.	ISG15 ubiquitin like modifier.	0.747
IFNB1	M3XQ69_MUSPF	ENSMPUP00000019400	ENSMPUP00000001219	Interferon beta.	Uncharacterized protein.	0.959
IFNB1	MYD88	ENSMPUP00000019400	ENSMPUP00000002726	Interferon beta.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.644
IFNB1	STAT1	ENSMPUP00000019400	ENSMPUP00000012436	Interferon beta.	Signal transducer and activator of transcription.	0.794
IFNB1	STAT2	ENSMPUP00000019400	ENSMPUP00000001419	Interferon beta.	Signal transducer and activator of transcription.	0.708
IKBKE	IFNB1	ENSMPUP00000011981	ENSMPUP00000019400	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Interferon beta.	0.410