(61 nodes) Organ growth network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ARX	Aristaless related homeobox. (554 aa)
	ARID2	AT-rich interaction domain 2. (1777 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	LEPR	Leptin receptor. (1164 aa)
	M3XP97_MUSPF	ANK_REP_REGION domain-containing protein. (132 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	LOC101674075	Homeobox domain-containing protein. (246 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (876 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	TBX5	T-box transcription factor 5. (559 aa)
	IFT80	Intraflagellar transport 80. (766 aa)
	STC1	Stanniocalcin 1. (247 aa)
	OSTN	Osteocrin. (132 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (924 aa)
	HLX	H2.0 like homeobox. (449 aa)
	BNC2	Basonuclin 2. (1085 aa)
	HEG1	Heart development protein with EGF like domains 1. (1278 aa)
	TGFB2	Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
	ECM1	Extracellular matrix protein 1. (564 aa)
	NPPC	Natriuretic peptide C. (126 aa)
	SAV1	Salvador family WW domain containing protein 1. (384 aa)
	M3Y243_MUSPF	zf-C5HC2 domain-containing protein. (128 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1092 aa)
	THBS3	Thrombospondin 3. (956 aa)
	GATA6	GATA binding protein 6. (482 aa)
	RARG	Retinoic acid receptor gamma. (458 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
	MMP13	Matrix metallopeptidase 13. (511 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (658 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (602 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
	TMEM38B	Transmembrane protein 38B. (291 aa)
	YAP1	Yes associated protein 1. (325 aa)
	EVC	EvC ciliary complex subunit 1. (993 aa)
	TENM4	Teneurin transmembrane protein 4. (2855 aa)
	FXN	Frataxin. (155 aa)
	IL7	Interleukin 7. (158 aa)
	PLAG1	PLAG1 zinc finger. (499 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (597 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1270 aa)
	NOTCH1	Notch receptor 1. (2119 aa)
	DIPK2A	Divergent protein kinase domain 2A. (430 aa)
	RARB	Retinoic acid receptor beta. (448 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	LOC101677498	DUF3496 domain-containing protein. (265 aa)
	ANXA6	Annexin. (673 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	SOX9	SRY-box transcription factor 9. (522 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (422 aa)
	STK3	Serine/threonine kinase 3. (418 aa)
	MATN1	Matrilin 1. (497 aa)
	COMP	Cartilage oligomeric matrix protein. (756 aa)
	M3YY40_MUSPF	DUF3496 domain-containing protein. (376 aa)
	STK4	Serine/threonine kinase 4. (487 aa)
	PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta. (415 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	RAG2	Recombination activating 2. (527 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP10	GATA6	ENSMPUP00000006259	ENSMPUP00000005576	Bone morphogenetic protein 10.	GATA binding protein 6.	0.412
BMP10	TBX5	ENSMPUP00000006259	ENSMPUP00000002687	Bone morphogenetic protein 10.	T-box transcription factor 5.	0.462
COMP	MATN1	ENSMPUP00000015407	ENSMPUP00000015351	Cartilage oligomeric matrix protein.	Matrilin 1.	0.465
COMP	MMP13	ENSMPUP00000015407	ENSMPUP00000006786	Cartilage oligomeric matrix protein.	Matrix metallopeptidase 13.	0.586
COMP	SOX9	ENSMPUP00000015407	ENSMPUP00000014195	Cartilage oligomeric matrix protein.	SRY-box transcription factor 9.	0.526
COMP	THBS3	ENSMPUP00000015407	ENSMPUP00000005564	Cartilage oligomeric matrix protein.	Thrombospondin 3.	0.846
DLL1	NOTCH1	ENSMPUP00000006989	ENSMPUP00000011233	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.992
ESR1	LEP	ENSMPUP00000010404	ENSMPUP00000006474	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.753
ESR1	NOTCH1	ENSMPUP00000010404	ENSMPUP00000011233	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Notch receptor 1.	0.531
ESR1	PLAG1	ENSMPUP00000010404	ENSMPUP00000010370	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	PLAG1 zinc finger.	0.433
ESR1	UBE3A	ENSMPUP00000010404	ENSMPUP00000002393	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.617
FGF10	FGF7	ENSMPUP00000014301	ENSMPUP00000012246	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
FGF10	PTPN11	ENSMPUP00000014301	ENSMPUP00000002504	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.545
FGF10	SOX9	ENSMPUP00000014301	ENSMPUP00000014195	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 9.	0.532
FGF7	FGF10	ENSMPUP00000012246	ENSMPUP00000014301	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
FGF7	PTPN11	ENSMPUP00000012246	ENSMPUP00000002504	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.402
FGF7	SOX9	ENSMPUP00000012246	ENSMPUP00000014195	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 9.	0.543
FGF7	TGFB2	ENSMPUP00000012246	ENSMPUP00000004208	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...]	0.423
FGF9	PTPN11	ENSMPUP00000000617	ENSMPUP00000002504	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.461
FGF9	SOX9	ENSMPUP00000000617	ENSMPUP00000014195	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 9.	0.597