STRINGSTRING
SMC5 SMC5 SMCHD1 SMCHD1 LMNA LMNA SIRT6 SIRT6 ZBTB7A ZBTB7A VCP VCP PARP1 PARP1 SLF1 SLF1 RNF168 RNF168 PHF1 PHF1 PNKP PNKP ARPC3 ARPC3 SMARCAD1 SMARCAD1 UFL1 UFL1 M3XQT3_MUSPF M3XQT3_MUSPF M3XQS3_MUSPF M3XQS3_MUSPF M3XQK8_MUSPF M3XQK8_MUSPF M3XQD6_MUSPF M3XQD6_MUSPF ESCO2 ESCO2 RIF1 RIF1 M3YDB4_MUSPF M3YDB4_MUSPF M3YDA5_MUSPF M3YDA5_MUSPF M3YDA0_MUSPF M3YDA0_MUSPF M3YD97_MUSPF M3YD97_MUSPF M3YD94_MUSPF M3YD94_MUSPF RNF169 RNF169 TP53 TP53 WRAP53 WRAP53 SHLD2 SHLD2 RAD51 RAD51 M3YAK6_MUSPF M3YAK6_MUSPF M3YAI7_MUSPF M3YAI7_MUSPF INTS3 INTS3 XRCC4 XRCC4 APLF APLF TONSL TONSL RBBP8 RBBP8 ARPC4 ARPC4 RAD18 RAD18 SLF2 SLF2 POLL POLL NHEJ1 NHEJ1 M3YYJ9_MUSPF M3YYJ9_MUSPF SMARCAL1 SMARCAL1 WDR70 WDR70 PRPF19 PRPF19 DDB1 DDB1 RNF8 RNF8 ATF2 ATF2 WAS WAS SMC6 SMC6 M3Z0L1_MUSPF M3Z0L1_MUSPF POLH POLH NABP1 NABP1 MRE11 MRE11 PARP3 PARP3 ARPC5 ARPC5 FAM178B FAM178B NBN NBN M3Z0L0_MUSPF M3Z0L0_MUSPF PAXX PAXX ACTR3 ACTR3 M3YGI1_MUSPF M3YGI1_MUSPF TP53BP1 TP53BP1 RFWD3 RFWD3 M3Z8M5_MUSPF M3Z8M5_MUSPF HUS1 HUS1 SAMHD1 SAMHD1 HELB HELB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMC5SMC_N domain-containing protein. (1026 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (2007 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (665 aa)
SIRT6Sirtuin 6. (359 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (550 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1145 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (572 aa)
PHF1PHD finger protein 1. (567 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (520 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
SMARCAD1Uncharacterized protein. (1028 aa)
UFL1UFM1 specific ligase 1. (792 aa)
M3XQT3_MUSPFUncharacterized protein. (1208 aa)
M3XQS3_MUSPFUncharacterized protein. (272 aa)
M3XQK8_MUSPFArp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (279 aa)
M3XQD6_MUSPFOB domain-containing protein. (211 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (613 aa)
RIF1Replication timing regulatory factor 1. (2475 aa)
M3YDB4_MUSPFUncharacterized protein; Belongs to the actin family. (409 aa)
M3YDA5_MUSPFHelicase ATP-binding domain-containing protein. (91 aa)
M3YDA0_MUSPFHelicase C-terminal domain-containing protein. (105 aa)
M3YD97_MUSPFHAND domain-containing protein. (88 aa)
M3YD94_MUSPFSLIDE domain-containing protein. (67 aa)
RNF169Ring finger protein 169. (607 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
WRAP53WD repeat containing antisense to TP53. (539 aa)
SHLD2Shieldin complex subunit 2. (906 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
M3YAK6_MUSPFUncharacterized protein. (932 aa)
M3YAI7_MUSPFDUF2439 domain-containing protein. (1074 aa)
INTS3Integrator complex subunit 3. (987 aa)
XRCC4X-ray repair cross complementing 4. (506 aa)
APLFAprataxin and PNKP like factor. (524 aa)
TONSLTonsoku like, DNA repair protein. (1212 aa)
RBBP8RB binding protein 8, endonuclease. (897 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (501 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1173 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (595 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
M3YYJ9_MUSPFArp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (959 aa)
WDR70WD repeat domain 70. (626 aa)
PRPF19Pre-mRNA processing factor 19. (504 aa)
DDB1Damage specific DNA binding protein 1. (1114 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
WASWASP actin nucleation promoting factor. (501 aa)
SMC6Structural maintenance of chromosomes 6. (1097 aa)
M3Z0L1_MUSPFUncharacterized protein. (110 aa)
POLHDNA polymerase eta. (649 aa)
NABP1Nucleic acid binding protein 1. (173 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
PARP3Poly [ADP-ribose] polymerase. (531 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
FAM178BFamily with sequence similarity 178 member B. (654 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (749 aa)
M3Z0L0_MUSPFUncharacterized protein. (103 aa)
PAXXPAXX non-homologous end joining factor. (204 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
M3YGI1_MUSPFZinc-hook domain-containing protein. (1312 aa)
TP53BP1Tumor protein p53 binding protein 1. (1969 aa)
RFWD3Ring finger and WD repeat domain 3. (772 aa)
M3Z8M5_MUSPFUncharacterized protein. (211 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (626 aa)
HELBDNA helicase B. (1080 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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