(42 nodes) Cellular response to glucose starvation network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SESN1	Sestrin 1. (551 aa)
	FOXO3	Forkhead box O3. (671 aa)
	M3YE86_MUSPF	Uncharacterized protein. (766 aa)
	ITFG2	Integrin alpha FG-GAP repeat containing 2. (444 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1065 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (529 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (524 aa)
	IMPACT	Impact RWD domain protein. (318 aa)
	ATG14	Autophagy related 14. (467 aa)
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (454 aa)
	PLIN3	Perilipin; Belongs to the perilipin family. (437 aa)
	SH3GLB1	SH3 domain containing GRB2 like, endophilin B1. (401 aa)
	KPTN	Kaptin, actin binding protein. (436 aa)
	SIK2	Salt inducible kinase 2. (926 aa)
	ASNS	Asparagine synthetase [glutamine-hydrolyzing]. (561 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
	BHLHA15	Basic helix-loop-helix family member a15. (187 aa)
	SESN3	Sestrin 3. (495 aa)
	PICK1	Protein interacting with PRKCA 1. (417 aa)
	MTMR3	Myotubularin related protein 3. (1211 aa)
	M3YPM9_MUSPF	BZIP domain-containing protein. (351 aa)
	M3YQ14_MUSPF	BZIP domain-containing protein. (346 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (3426 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	M3YRV1_MUSPF	Uncharacterized protein. (286 aa)
	NIM1K	NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. (436 aa)
	PRKAG1	Protein kinase AMP-activated non-catalytic subunit gamma 1. (329 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (517 aa)
	NUAK1	NUAK family kinase 1. (668 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (576 aa)
	SESN2	Sestrin 2. (479 aa)
	TBL2	Transducin beta like 2. (367 aa)
	PRKAG3	Protein kinase AMP-activated non-catalytic subunit gamma 3. (488 aa)
	C12orf66	Chromosome 12 open reading frame 66. (445 aa)
	SIRT1	Sirtuin 1. (557 aa)
	NUAK2	NUAK family kinase 2. (664 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
	MYBBP1A	MYB binding protein 1a. (1327 aa)
	PLIN2	Perilipin; Belongs to the perilipin family. (437 aa)
	BECN1	Beclin 1. (448 aa)
	M3YEN4_MUSPF	BZIP domain-containing protein. (358 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASNS	M3YEN4_MUSPF	ENSMPUP00000001487	ENSMPUP00000009791	Asparagine synthetase [glutamine-hydrolyzing].	BZIP domain-containing protein.	0.635
ASNS	M3YPM9_MUSPF	ENSMPUP00000001487	ENSMPUP00000013287	Asparagine synthetase [glutamine-hydrolyzing].	BZIP domain-containing protein.	0.635
ASNS	M3YQ14_MUSPF	ENSMPUP00000001487	ENSMPUP00000013422	Asparagine synthetase [glutamine-hydrolyzing].	BZIP domain-containing protein.	0.412
ATG14	BECN1	ENSMPUP00000005736	ENSMPUP00000010024	Autophagy related 14.	Beclin 1.	0.999
ATG14	PIK3C3	ENSMPUP00000005736	ENSMPUP00000001010	Autophagy related 14.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.999
ATG14	PRKAA1	ENSMPUP00000005736	ENSMPUP00000014643	Autophagy related 14.	Non-specific serine/threonine protein kinase.	0.566
ATG14	PRKAA2	ENSMPUP00000005736	ENSMPUP00000007189	Autophagy related 14.	Non-specific serine/threonine protein kinase.	0.541
BECN1	ATG14	ENSMPUP00000010024	ENSMPUP00000005736	Beclin 1.	Autophagy related 14.	0.999
BECN1	FOXO3	ENSMPUP00000010024	ENSMPUP00000009773	Beclin 1.	Forkhead box O3.	0.449
BECN1	HSPA5	ENSMPUP00000010024	ENSMPUP00000013783	Beclin 1.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.549
BECN1	M3YQ14_MUSPF	ENSMPUP00000010024	ENSMPUP00000013422	Beclin 1.	BZIP domain-containing protein.	0.416
BECN1	PIK3C3	ENSMPUP00000010024	ENSMPUP00000001010	Beclin 1.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.999
BECN1	PRKAA1	ENSMPUP00000010024	ENSMPUP00000014643	Beclin 1.	Non-specific serine/threonine protein kinase.	0.585
BECN1	PRKAA2	ENSMPUP00000010024	ENSMPUP00000007189	Beclin 1.	Non-specific serine/threonine protein kinase.	0.609
BECN1	PRKAG1	ENSMPUP00000010024	ENSMPUP00000014575	Beclin 1.	Protein kinase AMP-activated non-catalytic subunit gamma 1.	0.608
BECN1	PRKAG2	ENSMPUP00000010024	ENSMPUP00000008929	Beclin 1.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.567
BECN1	PRKAG3	ENSMPUP00000010024	ENSMPUP00000016446	Beclin 1.	Protein kinase AMP-activated non-catalytic subunit gamma 3.	0.554
BECN1	SH3GLB1	ENSMPUP00000010024	ENSMPUP00000004792	Beclin 1.	SH3 domain containing GRB2 like, endophilin B1.	0.658
BECN1	SIRT1	ENSMPUP00000010024	ENSMPUP00000011868	Beclin 1.	Sirtuin 1.	0.523
BECN1	TP53	ENSMPUP00000010024	ENSMPUP00000008945	Beclin 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.718