(62 nodes) Negative regulation of ion transport network (Mustela putorius)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	PAWR	Pro-apoptotic WT1 regulator. (360 aa)
	SLC43A2	Solute carrier family 43, member 2. (570 aa)
	ACTN2	Actinin alpha 2. (894 aa)
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (149 aa)
	GABRE	Gamma-aminobutyric acid type A receptor epsilon subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (494 aa)
	WNK3	WNK lysine deficient protein kinase 3. (1731 aa)
	M3YHX5_MUSPF	Uncharacterized protein. (112 aa)
	VIP	Vasoactive intestinal peptide. (170 aa)
	WNK4	WNK lysine deficient protein kinase 4. (1242 aa)
	GEM	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
	CBARP	CACN subunit beta associated regulatory protein. (552 aa)
	ANO9	Anoctamin. (781 aa)
	KEL	Kell metallo-endopeptidase (Kell blood group). (691 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (156 aa)
	GNB5	G protein subunit beta 5. (301 aa)
	KCNH2	Potassium voltage-gated channel subfamily H member 2. (1159 aa)
	HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1584 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	REM2	RRAD and GEM like GTPase 2. (342 aa)
	RRAD	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
	SYT11	Synaptotagmin 11. (431 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (151 aa)
	PACSIN3	Protein kinase C and casein kinase substrate in neurons 3. (499 aa)
	WNK2	WNK lysine deficient protein kinase 2. (1899 aa)
	PPIF	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (211 aa)
	STC1	Stanniocalcin 1. (247 aa)
	OXSR1	Oxidative stress responsive kinase 1. (461 aa)
	SESTD1	SEC14 and spectrin domain containing 1. (683 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (915 aa)
	NEDD4	E3 ubiquitin-protein ligase. (904 aa)
	CASQ2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (505 aa)
	M3XQH2_MUSPF	Uncharacterized protein. (130 aa)
	TRIM27	Tripartite motif containing 27. (516 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	STK39	Serine/threonine kinase 39. (546 aa)
	DRD3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (447 aa)
	SLC43A1	Solute carrier family 43 member 1. (559 aa)
	KCNE4	Potassium voltage-gated channel subfamily E regulatory subunit 4. (170 aa)
	M3Z785_MUSPF	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	KCNE3	Potassium voltage-gated channel subfamily E regulatory subunit 3. (99 aa)
	M3Z6U8_MUSPF	Small ubiquitin-related modifier. (100 aa)
	KCNE2	Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
	SRI	Sorcin. (198 aa)
	SFRP4	Secreted frizzled related protein 4. (346 aa)
	M3Z374_MUSPF	Uncharacterized protein. (1599 aa)
	WNK1	WNK lysine deficient protein kinase 1. (2832 aa)
	REM1	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
	M3Z1Q3_MUSPF	Uncharacterized protein. (150 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (473 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	FKBP1B	Peptidylprolyl isomerase. (209 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
	GOPC	PDZ domain-containing protein. (463 aa)
	SLC30A1	Solute carrier family 30 member 1. (505 aa)
	NEDD4L	NEDD4 like E3 ubiquitin protein ligase. (999 aa)
	GRP	Gastrin releasing peptide. (147 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (411 aa)
	PXK	PX domain containing serine/threonine kinase like. (583 aa)
	ARL6IP5	PRA1 family protein. (188 aa)
	CRBN	Cereblon. (444 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	TRH	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (246 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN2	CASQ2	ENSMPUP00000012647	ENSMPUP00000001648	Actinin alpha 2.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.519
CALM1	CAV1	ENSMPUP00000008029	ENSMPUP00000007166	Calmodulin 1; Belongs to the calmodulin family.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.798
CALM1	CAV3	ENSMPUP00000008029	ENSMPUP00000016953	Calmodulin 1; Belongs to the calmodulin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.814
CALM1	FKBP1B	ENSMPUP00000008029	ENSMPUP00000013836	Calmodulin 1; Belongs to the calmodulin family.	Peptidylprolyl isomerase.	0.879
CALM1	M3Z785_MUSPF	ENSMPUP00000008029	ENSMPUP00000019448	Calmodulin 1; Belongs to the calmodulin family.	Uncharacterized protein; Belongs to the calmodulin family.	0.701
CALM2	CASQ2	ENSMPUP00000011969	ENSMPUP00000001648	Calmodulin 2; Belongs to the calmodulin family.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.442
CALM2	CAV1	ENSMPUP00000011969	ENSMPUP00000007166	Calmodulin 2; Belongs to the calmodulin family.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.798
CALM2	CAV3	ENSMPUP00000011969	ENSMPUP00000016953	Calmodulin 2; Belongs to the calmodulin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.814
CALM2	FKBP1B	ENSMPUP00000011969	ENSMPUP00000013836	Calmodulin 2; Belongs to the calmodulin family.	Peptidylprolyl isomerase.	0.879
CALM2	M3Z785_MUSPF	ENSMPUP00000011969	ENSMPUP00000019448	Calmodulin 2; Belongs to the calmodulin family.	Uncharacterized protein; Belongs to the calmodulin family.	0.701
CALM3	CAV1	ENSMPUP00000005223	ENSMPUP00000007166	Calmodulin 3; Belongs to the calmodulin family.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.798
CALM3	CAV3	ENSMPUP00000005223	ENSMPUP00000016953	Calmodulin 3; Belongs to the calmodulin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.814
CALM3	FKBP1B	ENSMPUP00000005223	ENSMPUP00000013836	Calmodulin 3; Belongs to the calmodulin family.	Peptidylprolyl isomerase.	0.880
CALM3	KCNE3	ENSMPUP00000005223	ENSMPUP00000019405	Calmodulin 3; Belongs to the calmodulin family.	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.419
CALM3	M3Z785_MUSPF	ENSMPUP00000005223	ENSMPUP00000019448	Calmodulin 3; Belongs to the calmodulin family.	Uncharacterized protein; Belongs to the calmodulin family.	0.701
CASQ2	ACTN2	ENSMPUP00000001648	ENSMPUP00000012647	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Actinin alpha 2.	0.519
CASQ2	CALM2	ENSMPUP00000001648	ENSMPUP00000011969	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calmodulin 2; Belongs to the calmodulin family.	0.442
CASQ2	CAV3	ENSMPUP00000001648	ENSMPUP00000016953	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.413
CASQ2	FKBP1B	ENSMPUP00000001648	ENSMPUP00000013836	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Peptidylprolyl isomerase.	0.503
CASQ2	KCNH2	ENSMPUP00000001648	ENSMPUP00000007505	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Potassium voltage-gated channel subfamily H member 2.	0.663