(43 nodes) CD4-positive, alpha-beta T cell differentiation network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	SASH3	SAM and SH3 domain containing 3. (380 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
	NKX2-3	NK2 homeobox 3. (281 aa)
	FUT7	Fucosyltransferase 7. (342 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	TOX	Thymocyte selection associated high mobility group box. (526 aa)
	CRACR2A	Calcium release activated channel regulator 2A. (709 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (125 aa)
	LEF1	Lymphoid enhancer binding factor 1. (400 aa)
	IRF4	Interferon regulatory factor 4. (451 aa)
	IL6R	Interleukin 6 receptor. (436 aa)
	CTSV	Cathepsin V; Belongs to the peptidase C1 family. (335 aa)
	BCL3	BCL3 transcription coactivator. (456 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1131 aa)
	SEMA4A	Semaphorin 4A; Belongs to the semaphorin family. (761 aa)
	M3XZW3_MUSPF	Fibronectin type-III domain-containing protein. (374 aa)
	M3XZP3_MUSPF	HMG box domain-containing protein. (215 aa)
	HLX	H2.0 like homeobox. (449 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (715 aa)
	STAT6	Signal transducer and activator of transcription. (844 aa)
	PAX1	Paired box 1. (452 aa)
	RORA	RAR related orphan receptor A. (430 aa)
	CD83	CD83 molecule. (199 aa)
	M3XM17_MUSPF	Uncharacterized protein. (208 aa)
	IL18R1	Interleukin 18 receptor 1. (539 aa)
	ENTPD7	Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (651 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
	GATA3	GATA binding protein 3. (444 aa)
	TBX21	T-box transcription factor 21. (535 aa)
	M3YUJ9_MUSPF	HMG box domain-containing protein. (171 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (489 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	RAB44	Uncharacterized protein. (245 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1189 aa)
	M3YRQ6_MUSPF	Ig-like domain-containing protein. (336 aa)
	FOXP3	Forkhead box P3. (433 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (331 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (364 aa)
	IL4R	Interleukin 4 receptor. (805 aa)
	ARMC5	Armadillo repeat containing 5. (936 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BATF	BCL6	ENSMPUP00000009067	ENSMPUP00000003385	Basic leucine zipper ATF-like transcription factor.	BCL6 transcription repressor.	0.560
BATF	FOXP3	ENSMPUP00000009067	ENSMPUP00000013948	Basic leucine zipper ATF-like transcription factor.	Forkhead box P3.	0.527
BATF	GATA3	ENSMPUP00000009067	ENSMPUP00000016298	Basic leucine zipper ATF-like transcription factor.	GATA binding protein 3.	0.565
BATF	IRF4	ENSMPUP00000009067	ENSMPUP00000007790	Basic leucine zipper ATF-like transcription factor.	Interferon regulatory factor 4.	0.827
BATF	STAT3	ENSMPUP00000009067	ENSMPUP00000010432	Basic leucine zipper ATF-like transcription factor.	Signal transducer and activator of transcription.	0.600
BATF	TBX21	ENSMPUP00000009067	ENSMPUP00000015162	Basic leucine zipper ATF-like transcription factor.	T-box transcription factor 21.	0.438
BCL6	BATF	ENSMPUP00000003385	ENSMPUP00000009067	BCL6 transcription repressor.	Basic leucine zipper ATF-like transcription factor.	0.560
BCL6	FOXP3	ENSMPUP00000003385	ENSMPUP00000013948	BCL6 transcription repressor.	Forkhead box P3.	0.817
BCL6	GATA3	ENSMPUP00000003385	ENSMPUP00000016298	BCL6 transcription repressor.	GATA binding protein 3.	0.568
BCL6	GPR183	ENSMPUP00000003385	ENSMPUP00000018950	BCL6 transcription repressor.	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family.	0.463
BCL6	IL21	ENSMPUP00000003385	ENSMPUP00000017281	BCL6 transcription repressor.	Interleukin; Belongs to the IL-15/IL-21 family.	0.603
BCL6	IL6	ENSMPUP00000003385	ENSMPUP00000013489	BCL6 transcription repressor.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.521
BCL6	IRF4	ENSMPUP00000003385	ENSMPUP00000007790	BCL6 transcription repressor.	Interferon regulatory factor 4.	0.943
BCL6	M3YRQ6_MUSPF	ENSMPUP00000003385	ENSMPUP00000014016	BCL6 transcription repressor.	Ig-like domain-containing protein.	0.447
BCL6	STAT3	ENSMPUP00000003385	ENSMPUP00000010432	BCL6 transcription repressor.	Signal transducer and activator of transcription.	0.586
BCL6	STAT6	ENSMPUP00000003385	ENSMPUP00000001728	BCL6 transcription repressor.	Signal transducer and activator of transcription.	0.431
BCL6	TBX21	ENSMPUP00000003385	ENSMPUP00000015162	BCL6 transcription repressor.	T-box transcription factor 21.	0.600
BRAF	STAT3	ENSMPUP00000003381	ENSMPUP00000010432	B-Raf proto-oncogene, serine/threonine kinase.	Signal transducer and activator of transcription.	0.689
CD83	FOXP3	ENSMPUP00000000702	ENSMPUP00000013948	CD83 molecule.	Forkhead box P3.	0.511
CD83	IL6	ENSMPUP00000000702	ENSMPUP00000013489	CD83 molecule.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.549