STRINGSTRING
LRRK2 LRRK2 EDN1 EDN1 TRIB1 TRIB1 TLR4 TLR4 TNFSF11 TNFSF11 ADRA2A ADRA2A DUSP19 DUSP19 P2RX7 P2RX7 M3XSY7_MUSPF M3XSY7_MUSPF M3XSY8_MUSPF M3XSY8_MUSPF DVL3 DVL3 TAOK3 TAOK3 MAP3K13 MAP3K13 NOD2 NOD2 ADIPOQ ADIPOQ PTPRJ PTPRJ M3XXC5_MUSPF M3XXC5_MUSPF DUSP10 DUSP10 FZD10 FZD10 CCL19 CCL19 MAP3K4 MAP3K4 AGT AGT FLT1 FLT1 HTR2B HTR2B DTNBP1 DTNBP1 BMP4 BMP4 SFRP2 SFRP2 GBA GBA HMGCR HMGCR SMPD1 SMPD1 SORL1 SORL1 M3Y377_MUSPF M3Y377_MUSPF MAP3K12 MAP3K12 KIT KIT CBLC CBLC BMP2 BMP2 PDGFD PDGFD BMP7 BMP7 PAQR3 PAQR3 M3Y653_MUSPF M3Y653_MUSPF ARHGEF5 ARHGEF5 AJUBA AJUBA CAV1 CAV1 EZH2 EZH2 TGFA TGFA DAB2IP DAB2IP KITLG KITLG PIK3R5 PIK3R5 PIK3R6 PIK3R6 FGF1 FGF1 M3YA49_MUSPF M3YA49_MUSPF M3YA60_MUSPF M3YA60_MUSPF THBS1 THBS1 INSR INSR M3YAV1_MUSPF M3YAV1_MUSPF IRAK1 IRAK1 TGFB3 TGFB3 MAP3K7 MAP3K7 EPGN EPGN RPS3 RPS3 ADAM9 ADAM9 M3YE36_MUSPF M3YE36_MUSPF M3YE56_MUSPF M3YE56_MUSPF AGER AGER IL34 IL34 M3YFY1_MUSPF M3YFY1_MUSPF FZD4 FZD4 NOX4 NOX4 PTPRC PTPRC LYN LYN SOS1 SOS1 DVL2 DVL2 TRAF2 TRAF2 TNF TNF HGS HGS LAX1 LAX1 DUSP16 DUSP16 TRAF6 TRAF6 MAP3K11 MAP3K11 NEK10 NEK10 ERN2 ERN2 RGS14 RGS14 MAP4K2 MAP4K2 VEGFA VEGFA FGF18 FGF18 PDGFB PDGFB MST1R MST1R INPP5K INPP5K TRIB2 TRIB2 TSG101 TSG101 FGD2 FGD2 M3YS01_MUSPF M3YS01_MUSPF MAP2K6 MAP2K6 KSR1 KSR1 NF1 NF1 TPD52L1 TPD52L1 ERN1 ERN1 MAP3K5 MAP3K5 CDK12 CDK12 CDK5RAP3 CDK5RAP3 NTRK3 NTRK3 PAK1 PAK1 AXIN1 AXIN1 TNFRSF11A TNFRSF11A TMEM130 TMEM130 EPHA4 EPHA4 PTPN6 PTPN6 CAV3 CAV3 PDCD10 PDCD10 FGF2 FGF2 IRAK3 IRAK3 PTPN1 PTPN1 TGFB1 TGFB1 MAP3K10 MAP3K10 PDGFA PDGFA TRIB3 TRIB3 SASH1 SASH1 EGFR EGFR PIK3CG PIK3CG SPRY2 SPRY2 SPRY1 SPRY1 NUP62 NUP62 SPRY4 SPRY4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRRK2Leucine rich repeat kinase 2. (2527 aa)
EDN1Endothelin 1. (202 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
ADRA2AAdrenoceptor alpha 2A; Belongs to the G-protein coupled receptor 1 family. (323 aa)
DUSP19Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (221 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (594 aa)
M3XSY7_MUSPFUncharacterized protein. (242 aa)
M3XSY8_MUSPFUncharacterized protein. (300 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
TAOK3TAO kinase 3. (914 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1219 aa)
M3XXC5_MUSPFNsp1_C domain-containing protein. (267 aa)
DUSP10Dual specificity phosphatase 10. (482 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
CCL19C-C motif chemokine. (108 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1463 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
FLT1Receptor protein-tyrosine kinase. (1338 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
DTNBP1Dystrobrevin binding protein 1. (349 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
GBAGlucosylceramidase. (547 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (914 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
SORL1Sortilin related receptor 1. (2211 aa)
M3Y377_MUSPFNTR domain-containing protein. (233 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (948 aa)
CBLCCbl proto-oncogene C. (516 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
PDGFDPlatelet derived growth factor D. (364 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PAQR3Progestin and adipoQ receptor family member 3. (309 aa)
M3Y653_MUSPFProtein kinase domain-containing protein. (212 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1595 aa)
AJUBAAjuba LIM protein. (548 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (753 aa)
TGFATransforming growth factor alpha. (158 aa)
DAB2IPDAB2 interacting protein. (1112 aa)
KITLGKIT ligand. (274 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (778 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (755 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
M3YA49_MUSPFUncharacterized protein. (659 aa)
M3YA60_MUSPFN-terminal Ras-GEF domain-containing protein. (178 aa)
THBS1Thrombospondin 1. (1170 aa)
INSRTyrosine-protein kinase receptor. (1352 aa)
M3YAV1_MUSPFUncharacterized protein. (270 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (696 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
EPGNEpithelial mitogen. (153 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
ADAM9ADAM metallopeptidase domain 9. (785 aa)
M3YE36_MUSPFUncharacterized protein. (77 aa)
M3YE56_MUSPFCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (576 aa)
AGERAdvanced glycosylation end-product specific receptor. (400 aa)
IL34Interleukin 34. (236 aa)
M3YFY1_MUSPFUncharacterized protein. (4033 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
NOX4NADPH oxidase 4. (578 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1298 aa)
LYNTyrosine-protein kinase. (512 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
DVL2Dishevelled segment polarity protein 2. (734 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (780 aa)
LAX1Lymphocyte transmembrane adaptor 1. (399 aa)
DUSP16Dual specificity phosphatase 16. (663 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (863 aa)
NEK10NIMA related kinase 10. (1173 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (926 aa)
RGS14Regulator of G protein signaling 14. (568 aa)
MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (847 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (242 aa)
MST1RMacrophage stimulating 1 receptor. (1399 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (473 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
TSG101Tumor susceptibility 101. (391 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (663 aa)
M3YS01_MUSPFIg-like domain-containing protein. (306 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
KSR1Kinase suppressor of ras 1. (848 aa)
NF1Neurofibromin 1. (2815 aa)
TPD52L1TPD52 like 1. (209 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (975 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1398 aa)
CDK12Cyclin dependent kinase 12. (1282 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (504 aa)
NTRK3Tyrosine-protein kinase receptor. (781 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
AXIN1Axin 1. (862 aa)
TNFRSF11ATNF receptor superfamily member 11a. (603 aa)
TMEM130Transmembrane protein 130. (423 aa)
EPHA4EPH receptor A4. (986 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PDCD10Programmed cell death 10. (212 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (628 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (424 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (936 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
TRIB3Tribbles pseudokinase 3. (358 aa)
SASH1SAM and SH3 domain containing 1. (1145 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
SPRY1Sprouty-like protein 1, antagonist of FGF signaling. (319 aa)
NUP62Nucleoporin 62. (527 aa)
SPRY4Sprouty RTK signaling antagonist 4. (299 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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