(53 nodes) Regulation of muscle adaptation network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	M3XLW6_MUSPF	Uncharacterized protein. (97 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
	TWF1	Twinfilin actin binding protein 1. (350 aa)
	EDN1	Endothelin 1. (202 aa)
	FBXO32	F-box protein 32. (335 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (208 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (401 aa)
	GLRX3	Glutaredoxin 3. (287 aa)
	M3XUF3_MUSPF	Myosin_tail_1 domain-containing protein. (182 aa)
	ACTN3	Actinin alpha 3 (gene/pseudogene). (904 aa)
	M3XVU9_MUSPF	Uncharacterized protein. (73 aa)
	MTPN	Myotrophin. (118 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (665 aa)
	CMYA5	Cardiomyopathy associated 5. (4054 aa)
	M3Y280_MUSPF	Uncharacterized protein. (94 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1252 aa)
	NOL3	Nucleolar protein 3. (217 aa)
	M3Y355_MUSPF	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (117 aa)
	M3Y3H1_MUSPF	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (244 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	M3Y4N7_MUSPF	Uncharacterized protein. (111 aa)
	M3Y4Z1_MUSPF	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (140 aa)
	MYH6	Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1594 aa)
	M3Y830_MUSPF	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (417 aa)
	GATA5	GATA binding protein 5. (404 aa)
	M3YAH8_MUSPF	Uncharacterized protein. (111 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	PDE9A	Phosphodiesterase. (625 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (461 aa)
	FOXO3	Forkhead box O3. (671 aa)
	BECN1	Beclin 1. (448 aa)
	TNNI1	Troponin I1, slow skeletal type. (187 aa)
	MEF2A	Myocyte enhancer factor 2A. (416 aa)
	NOTCH1	Notch receptor 1. (2119 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1206 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	MYMK	Myomaker, myoblast fusion factor. (221 aa)
	M3YRT0_MUSPF	SCP domain-containing protein; Belongs to the CRISP family. (201 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
	SRL	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (825 aa)
	SGCA	Sarcoglycan alpha. (466 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
	M3YXC0_MUSPF	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (109 aa)
	GTF2IRD1	GTF2I repeat domain containing 1. (931 aa)
	LOC101689163	Uncharacterized protein. (901 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (509 aa)
	PRKAG3	Protein kinase AMP-activated non-catalytic subunit gamma 3. (488 aa)
	TNNC1	Troponin C1, slow skeletal and cardiac type. (185 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (501 aa)
	LMCD1	LIM and cysteine rich domains 1. (363 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	TRPC3	Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (866 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN3	M3XUF3_MUSPF	ENSMPUP00000003128	ENSMPUP00000002703	Actinin alpha 3 (gene/pseudogene).	Myosin_tail_1 domain-containing protein.	0.413
ACTN3	M3XVU9_MUSPF	ENSMPUP00000003128	ENSMPUP00000003199	Actinin alpha 3 (gene/pseudogene).	Uncharacterized protein.	0.415
ACTN3	M3Y355_MUSPF	ENSMPUP00000003128	ENSMPUP00000005756	Actinin alpha 3 (gene/pseudogene).	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.415
ACTN3	M3Y3H1_MUSPF	ENSMPUP00000003128	ENSMPUP00000005872	Actinin alpha 3 (gene/pseudogene).	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.411
ACTN3	M3Y4N7_MUSPF	ENSMPUP00000003128	ENSMPUP00000006288	Actinin alpha 3 (gene/pseudogene).	Uncharacterized protein.	0.413
ACTN3	M3Y4Z1_MUSPF	ENSMPUP00000003128	ENSMPUP00000006392	Actinin alpha 3 (gene/pseudogene).	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.433
ACTN3	M3YAH8_MUSPF	ENSMPUP00000003128	ENSMPUP00000008335	Actinin alpha 3 (gene/pseudogene).	Uncharacterized protein.	0.411
ACTN3	M3YXC0_MUSPF	ENSMPUP00000003128	ENSMPUP00000015980	Actinin alpha 3 (gene/pseudogene).	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.426
ACTN3	MYH6	ENSMPUP00000003128	ENSMPUP00000006401	Actinin alpha 3 (gene/pseudogene).	Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.411
ACTN3	TNNC1	ENSMPUP00000003128	ENSMPUP00000016668	Actinin alpha 3 (gene/pseudogene).	Troponin C1, slow skeletal and cardiac type.	0.603
ACTN3	TNNI1	ENSMPUP00000003128	ENSMPUP00000010721	Actinin alpha 3 (gene/pseudogene).	Troponin I1, slow skeletal type.	0.704
ATP2B4	TNNI1	ENSMPUP00000011522	ENSMPUP00000010721	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Troponin I1, slow skeletal type.	0.547
BECN1	FOXO3	ENSMPUP00000010024	ENSMPUP00000009773	Beclin 1.	Forkhead box O3.	0.449
BECN1	PRKAG3	ENSMPUP00000010024	ENSMPUP00000016446	Beclin 1.	Protein kinase AMP-activated non-catalytic subunit gamma 3.	0.554
BMP10	SMAD4	ENSMPUP00000006259	ENSMPUP00000008705	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog.	0.473
CAV3	SGCA	ENSMPUP00000016953	ENSMPUP00000015309	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sarcoglycan alpha.	0.731
EDN1	HAND2	ENSMPUP00000000674	ENSMPUP00000001892	Endothelin 1.	Heart and neural crest derivatives expressed 2.	0.435
FOXO3	BECN1	ENSMPUP00000009773	ENSMPUP00000010024	Forkhead box O3.	Beclin 1.	0.449
FOXO3	PRKAG3	ENSMPUP00000009773	ENSMPUP00000016446	Forkhead box O3.	Protein kinase AMP-activated non-catalytic subunit gamma 3.	0.935
FOXO3	SMAD4	ENSMPUP00000009773	ENSMPUP00000008705	Forkhead box O3.	Mothers against decapentaplegic homolog.	0.853