(48 nodes) Mitotic G2/M transition checkpoint network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	IER3	Immediate early response 3. (155 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (749 aa)
	TOPBP1	DNA topoisomerase II binding protein 1. (1466 aa)
	INTS3	Integrator complex subunit 3. (987 aa)
	FOXN3	Forkhead box N3. (515 aa)
	M3Y878_MUSPF	Uncharacterized protein. (67 aa)
	ORC1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (862 aa)
	PLK1	Serine/threonine-protein kinase PLK. (542 aa)
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
	NAE1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (597 aa)
	BABAM1	BRISC and BRCA1 A complex member 1. (336 aa)
	FOXO4	Forkhead box O4. (509 aa)
	NOP53	NOP53 ribosome biogenesis factor. (486 aa)
	BRCC3	BRCA1/BRCA2-containing complex subunit 3. (316 aa)
	BABAM2	BRISC and BRCA1 A complex member 2. (383 aa)
	HUS1	Checkpoint protein; Belongs to the HUS1 family. (280 aa)
	RINT1	RAD50 interactor 1. (792 aa)
	M3Z4Z5_MUSPF	Uncharacterized protein. (472 aa)
	TRIM60	Tripartite motif containing 60. (466 aa)
	ZNF830	Zinc finger protein 830. (369 aa)
	M3Z8M5_MUSPF	Uncharacterized protein. (211 aa)
	MFSD11	Major facilitator superfamily domain containing 11. (449 aa)
	NABP1	Nucleic acid binding protein 1. (173 aa)
	UIMC1	Ubiquitin interaction motif containing 1. (644 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
	DTL	Denticleless E3 ubiquitin protein ligase homolog. (730 aa)
	M3YWI4_MUSPF	Uncharacterized protein. (246 aa)
	M3YWI3_MUSPF	Uncharacterized protein. (246 aa)
	TICRR	TOPBP1 interacting checkpoint and replication regulator. (1705 aa)
	BLM	BLM RecQ like helicase. (1221 aa)
	CDK5RAP3	CDK5 regulatory subunit associated protein 3. (504 aa)
	CDC6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
	CLSPN	Claspin. (1336 aa)
	ABRAXAS1	Abraxas 1, BRCA1 A complex subunit. (360 aa)
	RAD17	RAD17 checkpoint clamp loader component. (680 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	M3XQD6_MUSPF	OB domain-containing protein. (211 aa)
	DONSON	Downstream neighbor of SON. (470 aa)
	MRNIP	MRN complex interacting protein. (339 aa)
	FZR1	Fizzy and cell division cycle 20 related 1. (493 aa)
	TAOK3	TAO kinase 3. (914 aa)
	CHFR	Checkpoint with forkhead and ring finger domains. (632 aa)
	C10orf90	Chromosome 10 open reading frame 90. (687 aa)
	TRIM75P	Tripartite motif containing 75, pseudogene. (485 aa)
	LOC101688276	Uncharacterized protein. (479 aa)
	TRIM39	Tripartite motif containing 39. (488 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABRAXAS1	ATM	ENSMPUP00000014568	ENSMPUP00000005920	Abraxas 1, BRCA1 A complex subunit.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.569
ABRAXAS1	BABAM1	ENSMPUP00000014568	ENSMPUP00000015803	Abraxas 1, BRCA1 A complex subunit.	BRISC and BRCA1 A complex member 1.	0.999
ABRAXAS1	BABAM2	ENSMPUP00000014568	ENSMPUP00000017879	Abraxas 1, BRCA1 A complex subunit.	BRISC and BRCA1 A complex member 2.	0.998
ABRAXAS1	BRCC3	ENSMPUP00000014568	ENSMPUP00000016027	Abraxas 1, BRCA1 A complex subunit.	BRCA1/BRCA2-containing complex subunit 3.	0.999
ABRAXAS1	M3Y878_MUSPF	ENSMPUP00000014568	ENSMPUP00000007535	Abraxas 1, BRCA1 A complex subunit.	Uncharacterized protein.	0.692
ABRAXAS1	MRE11	ENSMPUP00000014568	ENSMPUP00000012153	Abraxas 1, BRCA1 A complex subunit.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.734
ABRAXAS1	NBN	ENSMPUP00000014568	ENSMPUP00000010920	Abraxas 1, BRCA1 A complex subunit.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.706
ABRAXAS1	UIMC1	ENSMPUP00000014568	ENSMPUP00000012202	Abraxas 1, BRCA1 A complex subunit.	Ubiquitin interaction motif containing 1.	0.998
ATM	ABRAXAS1	ENSMPUP00000005920	ENSMPUP00000014568	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Abraxas 1, BRCA1 A complex subunit.	0.569
ATM	BABAM1	ENSMPUP00000005920	ENSMPUP00000015803	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRISC and BRCA1 A complex member 1.	0.603
ATM	BABAM2	ENSMPUP00000005920	ENSMPUP00000017879	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRISC and BRCA1 A complex member 2.	0.660
ATM	BLM	ENSMPUP00000005920	ENSMPUP00000015547	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BLM RecQ like helicase.	0.878
ATM	BRCC3	ENSMPUP00000005920	ENSMPUP00000016027	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA1/BRCA2-containing complex subunit 3.	0.605
ATM	CDK1	ENSMPUP00000005920	ENSMPUP00000010967	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.719
ATM	CDKN1A	ENSMPUP00000005920	ENSMPUP00000014105	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase inhibitor 1A.	0.463
ATM	CHEK1	ENSMPUP00000005920	ENSMPUP00000006439	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.971
ATM	CLSPN	ENSMPUP00000005920	ENSMPUP00000014770	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Claspin.	0.632
ATM	HUS1	ENSMPUP00000005920	ENSMPUP00000018057	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Checkpoint protein; Belongs to the HUS1 family.	0.783
ATM	INTS3	ENSMPUP00000005920	ENSMPUP00000008161	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Integrator complex subunit 3.	0.624
ATM	MRE11	ENSMPUP00000005920	ENSMPUP00000012153	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.997