(36 nodes) T cell selection network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TBX21	T-box transcription factor 21. (535 aa)
	CD28	CD28 molecule. (255 aa)
	STAT6	Signal transducer and activator of transcription. (844 aa)
	M3XSG7_MUSPF	Uncharacterized protein. (233 aa)
	M3XSG8_MUSPF	Uncharacterized protein. (429 aa)
	BCL11B	BAF chromatin remodeling complex subunit BCL11B. (585 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (715 aa)
	CD3E	CD3 epsilon antigen. (186 aa)
	CD3D	CD3d molecule. (169 aa)
	ITPKB	Kinase; Belongs to the inositol phosphokinase (IPK) family. (938 aa)
	M3Y653_MUSPF	Protein kinase domain-containing protein. (212 aa)
	CTSV	Cathepsin V; Belongs to the peptidase C1 family. (335 aa)
	IL6R	Interleukin 6 receptor. (436 aa)
	IRF4	Interferon regulatory factor 4. (451 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (443 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (125 aa)
	M3YDD9_MUSPF	Uncharacterized protein. (516 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	AIRE	Autoimmune regulator. (559 aa)
	TOX	Thymocyte selection associated high mobility group box. (526 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1298 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	ZAP70	Tyrosine-protein kinase. (616 aa)
	DOCK2	Dedicator of cytokinesis 2; Belongs to the DOCK family. (1879 aa)
	SRF	Serum response factor. (508 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
	CD74	CD74 molecule. (279 aa)
	M3YRQ6_MUSPF	Ig-like domain-containing protein. (336 aa)
	THEMIS	Thymocyte selection associated. (647 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	GATA3	GATA binding protein 3. (444 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
	CD4	CD4. (462 aa)
	CARD11	Caspase recruitment domain family member 11. (1153 aa)
	GLI3	GLI family zinc finger 3. (1585 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIRE	CCR7	ENSMPUP00000009956	ENSMPUP00000014564	Autoimmune regulator.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.465
AIRE	CD4	ENSMPUP00000009956	ENSMPUP00000016704	Autoimmune regulator.	CD4.	0.440
ATG5	IL6	ENSMPUP00000009457	ENSMPUP00000013489	Autophagy protein 5; Involved in autophagic vesicle formation.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.434
ATG5	MTOR	ENSMPUP00000009457	ENSMPUP00000016325	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.527
BATF	BCL11B	ENSMPUP00000009067	ENSMPUP00000003001	Basic leucine zipper ATF-like transcription factor.	BAF chromatin remodeling complex subunit BCL11B.	0.513
BATF	CD4	ENSMPUP00000009067	ENSMPUP00000016704	Basic leucine zipper ATF-like transcription factor.	CD4.	0.463
BATF	GATA3	ENSMPUP00000009067	ENSMPUP00000016298	Basic leucine zipper ATF-like transcription factor.	GATA binding protein 3.	0.565
BATF	IRF4	ENSMPUP00000009067	ENSMPUP00000007790	Basic leucine zipper ATF-like transcription factor.	Interferon regulatory factor 4.	0.827
BATF	STAT3	ENSMPUP00000009067	ENSMPUP00000010432	Basic leucine zipper ATF-like transcription factor.	Signal transducer and activator of transcription.	0.600
BATF	TBX21	ENSMPUP00000009067	ENSMPUP00000015162	Basic leucine zipper ATF-like transcription factor.	T-box transcription factor 21.	0.438
BCL11B	BATF	ENSMPUP00000003001	ENSMPUP00000009067	BAF chromatin remodeling complex subunit BCL11B.	Basic leucine zipper ATF-like transcription factor.	0.513
BCL11B	GATA3	ENSMPUP00000003001	ENSMPUP00000016298	BAF chromatin remodeling complex subunit BCL11B.	GATA binding protein 3.	0.511
BRAF	STAT3	ENSMPUP00000003381	ENSMPUP00000010432	B-Raf proto-oncogene, serine/threonine kinase.	Signal transducer and activator of transcription.	0.689
CARD11	M3Y653_MUSPF	ENSMPUP00000017839	ENSMPUP00000006804	Caspase recruitment domain family member 11.	Protein kinase domain-containing protein.	0.548
CARD11	ZAP70	ENSMPUP00000017839	ENSMPUP00000011220	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.427
CCR7	AIRE	ENSMPUP00000014564	ENSMPUP00000009956	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Autoimmune regulator.	0.465
CCR7	CD28	ENSMPUP00000014564	ENSMPUP00000000415	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD28 molecule.	0.463
CCR7	CD3D	ENSMPUP00000014564	ENSMPUP00000004442	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD3d molecule.	0.560
CCR7	CD3E	ENSMPUP00000014564	ENSMPUP00000004435	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD3 epsilon antigen.	0.609
CCR7	CD4	ENSMPUP00000014564	ENSMPUP00000016704	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD4.	0.824