STRINGSTRING
EDNRA EDNRA DLL1 DLL1 DMRTA2 DMRTA2 IL6R IL6R CYP26B1 CYP26B1 PRADC1 PRADC1 LEO1 LEO1 DOCK7 DOCK7 IRF4 IRF4 TBX20 TBX20 GATA5 GATA5 ERBB4 ERBB4 MEF2C MEF2C TENM4 TENM4 APC2 APC2 WNT3 WNT3 WNT9B WNT9B DLL4 DLL4 SMAD4 SMAD4 WNT11 WNT11 GBX1 GBX1 GCM1 GCM1 RTF1 RTF1 KDM6B KDM6B MGA MGA TP53 TP53 BATF BATF TEAD4 TEAD4 PRDM1 PRDM1 M3YE59_MUSPF M3YE59_MUSPF WNT8A WNT8A M3YED9_MUSPF M3YED9_MUSPF NR2E1 NR2E1 SMAD5 SMAD5 PITX1 PITX1 IL7 IL7 TOX TOX SOX17 SOX17 STAT3 STAT3 EYA1 EYA1 POU1F1 POU1F1 M3YGU3_MUSPF M3YGU3_MUSPF EHMT2 EHMT2 TM2D3 TM2D3 PAX6 PAX6 NOTCH1 NOTCH1 TGFB1I1 TGFB1I1 KIAA1549L KIAA1549L SOX13 SOX13 LHX3 LHX3 SOX5 SOX5 EOMES EOMES SIX2 SIX2 WNT4 WNT4 MYL10 MYL10 SOX8 SOX8 TBX21 TBX21 TBX4 TBX4 EPAS1 EPAS1 TAL1 TAL1 RUNX2 RUNX2 TBX6 TBX6 TBX22 TBX22 APC APC TLX3 TLX3 CTR9 CTR9 MYT1L MYT1L SOX6 SOX6 PTCH2 PTCH2 PROX1 PROX1 MYOD1 MYOD1 IL6 IL6 GATA1 GATA1 GDF7 GDF7 DBX1 DBX1 SOSTDC1 SOSTDC1 HOXD10 HOXD10 M3YRQ6_MUSPF M3YRQ6_MUSPF FOXN1 FOXN1 SOX9 SOX9 ISL1 ISL1 FGF10 FGF10 DHH DHH WNT1 WNT1 WNT10B WNT10B TBX2 TBX2 EPOP EPOP HOXA11 HOXA11 HOXA13 HOXA13 WNT2B WNT2B ARHGEF2 ARHGEF2 GSX1 GSX1 KDR KDR TBX18 TBX18 FOXG1 FOXG1 BMP4 BMP4 SFRP2 SFRP2 GATA6 GATA6 M3Y348_MUSPF M3Y348_MUSPF GSX2 GSX2 M3Y377_MUSPF M3Y377_MUSPF HOXC10 HOXC10 SMO SMO ITGB1 ITGB1 VWA5A VWA5A ETV2 ETV2 ARX ARX GAP43 GAP43 TBX19 TBX19 TBR1 TBR1 LATS2 LATS2 EDN1 EDN1 DLX1 DLX1 DLX2 DLX2 WNT9A WNT9A WNT3A WNT3A EXT1 EXT1 NKX2-2 NKX2-2 OLIG2 OLIG2 LOC101674075 LOC101674075 TBX15 TBX15 STAT6 STAT6 GATA4 GATA4 TCF7L2 TCF7L2 M3XSG3_MUSPF M3XSG3_MUSPF M3XSG7_MUSPF M3XSG7_MUSPF M3XSG8_MUSPF M3XSG8_MUSPF MYL2 MYL2 VWA5B2 VWA5B2 TBX5 TBX5 TBX3 TBX3 BCL11B BCL11B GSC GSC SPDEF SPDEF BRAF BRAF FOXN4 FOXN4 HES1 HES1 KIAA1549 KIAA1549 M3XXR9_MUSPF M3XXR9_MUSPF TBX10 TBX10 NODAL NODAL BARHL2 BARHL2 HOXA2 HOXA2 RAG2 RAG2 NEUROG1 NEUROG1 NTF4 NTF4 ATOH1 ATOH1 OLIG3 OLIG3 SPRY2 SPRY2 GLI3 GLI3 LATS1 LATS1 WNT5B WNT5B PAF1 PAF1 ISL2 ISL2 GATA2 GATA2 PML PML WNT7A WNT7A MITF MITF WNT8B WNT8B LBX1 LBX1 FEZF2 FEZF2 SUFU SUFU WNT5A WNT5A NANOG NANOG IHH IHH FEV FEV WNT10A WNT10A WNT6 WNT6 ZNF521 ZNF521 BMP2 BMP2 SIX1 SIX1 TBXT TBXT CDON CDON ONECUT2 ONECUT2 MTOR MTOR GATA3 GATA3 PDPN PDPN NKX2-1 NKX2-1 FOXA1 FOXA1 WNT7B WNT7B VWA5B1 VWA5B1 TGFBR1 TGFBR1 PTCH1 PTCH1 SMAD1 SMAD1 WNT16 WNT16 CTSV CTSV
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (602 aa)
DMRTA2DMRT like family A2. (486 aa)
IL6RInterleukin 6 receptor. (436 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
PRADC1Protease associated domain containing 1. (188 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (664 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2143 aa)
IRF4Interferon regulatory factor 4. (451 aa)
TBX20T-box transcription factor 20. (446 aa)
GATA5GATA binding protein 5. (404 aa)
ERBB4Receptor protein-tyrosine kinase. (1224 aa)
MEF2CMyocyte enhancer factor 2C. (433 aa)
TENM4Teneurin transmembrane protein 4. (2855 aa)
APC2APC regulator of WNT signaling pathway 2. (2481 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
GBX1Gastrulation brain homeobox 1. (433 aa)
GCM1Glial cells missing transcription factor 1. (442 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa)
KDM6BLysine demethylase 6B. (1668 aa)
MGAMAX dimerization protein MGA. (3109 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
TEAD4TEA domain transcription factor 4. (361 aa)
PRDM1PR/SET domain 1. (818 aa)
M3YE59_MUSPFHH_signal domain-containing protein. (290 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
M3YED9_MUSPFHomeobox domain-containing protein. (242 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
PITX1Homeobox protein. (290 aa)
IL7Interleukin 7. (158 aa)
TOXThymocyte selection associated high mobility group box. (526 aa)
SOX17SRY-box transcription factor 17. (406 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
POU1F1POU domain protein. (357 aa)
M3YGU3_MUSPFUncharacterized protein. (267 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1270 aa)
TM2D3TM2 domain containing 3. (250 aa)
PAX6Paired box 6. (436 aa)
NOTCH1Notch receptor 1. (2119 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (470 aa)
KIAA1549LKIAA1549 like. (1852 aa)
SOX13SRY-box transcription factor 13. (615 aa)
LHX3LIM homeobox 3. (407 aa)
SOX5SRY-box transcription factor 5. (763 aa)
EOMESEomesodermin. (669 aa)
SIX2SIX homeobox 2. (296 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
MYL10Myosin light chain 10. (167 aa)
SOX8SRY-box transcription factor 8. (377 aa)
TBX21T-box transcription factor 21. (535 aa)
TBX4T-box transcription factor 4. (553 aa)
EPAS1Endothelial PAS domain protein 1. (868 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (346 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (507 aa)
TBX6T-box transcription factor 6. (436 aa)
TBX22T-box transcription factor 22. (522 aa)
APCAPC regulator of WNT signaling pathway. (2862 aa)
TLX3T cell leukemia homeobox 3. (338 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
MYT1LMyelin transcription factor 1 like. (1194 aa)
SOX6SRY-box transcription factor 6. (814 aa)
PTCH2Patched 2. (1207 aa)
PROX1Prospero homeobox 1. (737 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
GATA1GATA binding protein 1. (414 aa)
GDF7Growth differentiation factor 7. (382 aa)
DBX1Developing brain homeobox 1. (342 aa)
SOSTDC1Sclerostin domain containing 1. (209 aa)
HOXD10Homeobox D10. (410 aa)
M3YRQ6_MUSPFIg-like domain-containing protein. (336 aa)
FOXN1Forkhead box N1. (646 aa)
SOX9SRY-box transcription factor 9. (522 aa)
ISL1ISL LIM homeobox 1. (349 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
DHHDesert hedgehog signaling molecule. (299 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
TBX2T-box transcription factor 2. (679 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (369 aa)
HOXA11Homeobox A11. (269 aa)
HOXA13Homeobox A13. (259 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (909 aa)
GSX1GS homeobox 1. (253 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
TBX18T-box transcription factor 18. (612 aa)
FOXG1Forkhead box G1. (424 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
GATA6GATA binding protein 6. (482 aa)
M3Y348_MUSPFHomeobox domain-containing protein. (258 aa)
GSX2GS homeobox 2. (304 aa)
M3Y377_MUSPFNTR domain-containing protein. (233 aa)
HOXC10Homeobox C10. (342 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (790 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
VWA5AVon Willebrand factor A domain containing 5A. (802 aa)
ETV2ETS variant 2. (344 aa)
ARXAristaless related homeobox. (554 aa)
GAP43Growth associated protein 43. (242 aa)
TBX19T-box transcription factor 19. (446 aa)
TBR1T-box brain transcription factor 1. (682 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
EDN1Endothelin 1. (202 aa)
DLX1Distal-less homeobox 1. (255 aa)
DLX2Distal-less homeobox 2. (332 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (451 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
NKX2-2NK2 homeobox 2. (273 aa)
OLIG2Oligodendrocyte transcription factor 2. (295 aa)
LOC101674075Homeobox domain-containing protein. (246 aa)
TBX15T-box transcription factor 15. (602 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
GATA4GATA binding protein 4. (442 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
M3XSG3_MUSPFCTNNB1_binding domain-containing protein. (169 aa)
M3XSG7_MUSPFUncharacterized protein. (233 aa)
M3XSG8_MUSPFUncharacterized protein. (429 aa)
MYL2Myosin light chain 2. (166 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1249 aa)
TBX5T-box transcription factor 5. (559 aa)
TBX3T-box transcription factor 3. (757 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (585 aa)
GSCGoosecoid homeobox. (256 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (715 aa)
FOXN4Forkhead box N4. (514 aa)
HES1Hes family bHLH transcription factor 1. (283 aa)
KIAA1549KIAA1549. (1876 aa)
M3XXR9_MUSPFUncharacterized protein. (249 aa)
TBX10T-box transcription factor 10. (385 aa)
NODALNodal growth differentiation factor. (348 aa)
BARHL2BarH like homeobox 2. (370 aa)
HOXA2Homeobox A2. (378 aa)
RAG2Recombination activating 2. (527 aa)
NEUROG1Neurogenin 1. (247 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (211 aa)
ATOH1Atonal bHLH transcription factor 1. (359 aa)
OLIG3Oligodendrocyte transcription factor 3. (268 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
GLI3GLI family zinc finger 3. (1585 aa)
LATS1Large tumor suppressor kinase 1. (1127 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (406 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (554 aa)
ISL2ISL LIM homeobox 2. (359 aa)
GATA2GATA binding protein 2. (480 aa)
PMLPromyelocytic leukemia. (876 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
MITFMelanocyte inducing transcription factor. (520 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
LBX1Ladybird homeobox 1. (281 aa)
FEZF2FEZ family zinc finger 2. (460 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (383 aa)
NANOGHomeobox domain-containing protein. (310 aa)
IHHIndian hedgehog signaling molecule. (384 aa)
FEVFEV transcription factor, ETS family member. (247 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ZNF521Zinc finger protein 521. (1311 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SIX1SIX homeobox 1. (284 aa)
TBXTT-box transcription factor T. (395 aa)
CDONCell adhesion associated, oncogene regulated. (1260 aa)
ONECUT2One cut domain family member. (395 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
GATA3GATA binding protein 3. (444 aa)
PDPNPodoplanin. (177 aa)
NKX2-1NK2 homeobox 1. (371 aa)
FOXA1Forkhead box A1. (501 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1229 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (480 aa)
PTCH1Patched 1. (1386 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (335 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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