(28 nodes) Regulation of isotype switching network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	CLCF1	Cardiotrophin like cytokine factor 1. (281 aa)
	CD28	CD28 molecule. (255 aa)
	RIF1	Replication timing regulatory factor 1. (2475 aa)
	STAT6	Signal transducer and activator of transcription. (844 aa)
	TP53BP1	Tumor protein p53 binding protein 1. (1969 aa)
	TFRC	Transferrin receptor protein 1. (770 aa)
	KMT5B	Lysine methyltransferase 5B. (940 aa)
	THOC1	THO complex 1. (657 aa)
	TNFSF13	Tumor necrosis factor superfamily, member 13; Belongs to the tumor necrosis factor family. (252 aa)
	PAXIP1	PAX interacting protein 1. (1293 aa)
	SHLD2	Shieldin complex subunit 2. (906 aa)
	NDFIP1	Nedd4 family interacting protein 1. (211 aa)
	KMT5C	Lysine methyltransferase 5C. (459 aa)
	EXOSC3	Exosome component 3. (276 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1298 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	NSD2	Nuclear receptor binding SET domain protein 2. (1344 aa)
	PARP3	Poly [ADP-ribose] polymerase. (531 aa)
	FOXP3	Forkhead box P3. (433 aa)
	SUPT6H	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
	ATAD5	ATPase family AAA domain containing 5. (1892 aa)
	TBX21	T-box transcription factor 21. (535 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (211 aa)
	HMCES	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
	TGFB1	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
	IL27RA	Interleukin 27 receptor subunit alpha. (654 aa)
	BCL6	BCL6 transcription repressor. (706 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	MAD2L2	ENSMPUP00000014578	ENSMPUP00000016318	ATPase family AAA domain containing 5.	Mitotic arrest deficient 2 like 2.	0.594
BCL6	FOXP3	ENSMPUP00000003385	ENSMPUP00000013948	BCL6 transcription repressor.	Forkhead box P3.	0.817
BCL6	IL2	ENSMPUP00000003385	ENSMPUP00000017283	BCL6 transcription repressor.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.540
BCL6	STAT6	ENSMPUP00000003385	ENSMPUP00000001728	BCL6 transcription repressor.	Signal transducer and activator of transcription.	0.431
BCL6	TBX21	ENSMPUP00000003385	ENSMPUP00000015162	BCL6 transcription repressor.	T-box transcription factor 21.	0.600
CD28	FOXP3	ENSMPUP00000000415	ENSMPUP00000013948	CD28 molecule.	Forkhead box P3.	0.453
CD28	IL2	ENSMPUP00000000415	ENSMPUP00000017283	CD28 molecule.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.568
CD28	PTPRC	ENSMPUP00000000415	ENSMPUP00000010371	CD28 molecule.	Protein tyrosine phosphatase receptor type C.	0.430
CLCF1	IL27RA	ENSMPUP00000003753	ENSMPUP00000003088	Cardiotrophin like cytokine factor 1.	Interleukin 27 receptor subunit alpha.	0.575
FOXP3	BCL6	ENSMPUP00000013948	ENSMPUP00000003385	Forkhead box P3.	BCL6 transcription repressor.	0.817
FOXP3	CD28	ENSMPUP00000013948	ENSMPUP00000000415	Forkhead box P3.	CD28 molecule.	0.453
FOXP3	IL2	ENSMPUP00000013948	ENSMPUP00000017283	Forkhead box P3.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.911
FOXP3	STAT6	ENSMPUP00000013948	ENSMPUP00000001728	Forkhead box P3.	Signal transducer and activator of transcription.	0.613
FOXP3	TBX21	ENSMPUP00000013948	ENSMPUP00000015162	Forkhead box P3.	T-box transcription factor 21.	0.640
FOXP3	TGFB1	ENSMPUP00000013948	ENSMPUP00000017540	Forkhead box P3.	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]	0.646
IL2	BCL6	ENSMPUP00000017283	ENSMPUP00000003385	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	BCL6 transcription repressor.	0.540
IL2	CD28	ENSMPUP00000017283	ENSMPUP00000000415	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	CD28 molecule.	0.568
IL2	FOXP3	ENSMPUP00000017283	ENSMPUP00000013948	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Forkhead box P3.	0.911
IL2	IL27RA	ENSMPUP00000017283	ENSMPUP00000003088	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Interleukin 27 receptor subunit alpha.	0.862
IL2	STAT6	ENSMPUP00000017283	ENSMPUP00000001728	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Signal transducer and activator of transcription.	0.577