(28 nodes) Regulation of keratinocyte differentiation network (Mustela putorius)

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Your Input:
	M3Y544_MUSPF	Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
	M3Y5C0_MUSPF	Uncharacterized protein. (147 aa)
	KRT84	Keratin 84; Belongs to the intermediate filament family. (594 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (753 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (317 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2598 aa)
	ALOX15B	Arachidonate 15-lipoxygenase type B. (726 aa)
	ETV4	ETS variant 4. (479 aa)
	MACROH2A1	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	NUMA1	Nuclear mitotic apparatus protein 1. (1792 aa)
	KRT36	Keratin 36; Belongs to the intermediate filament family. (467 aa)
	NOTCH1	Notch receptor 1. (2119 aa)
	CYP27C1	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (416 aa)
	GRHL1	Grainyhead like transcription factor 1. (583 aa)
	M3YU90_MUSPF	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (616 aa)
	GRHL2	Grainyhead like transcription factor 2. (727 aa)
	NCOA3	Nuclear receptor coactivator. (1416 aa)
	SRSF6	Serine and arginine rich splicing factor 6. (288 aa)
	ZFP36	ZFP36 ring finger protein. (327 aa)
	ZBED2	Zinc finger BED-type containing 2. (218 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (586 aa)
	CD109	CD109 molecule. (1448 aa)
	MACROH2A2	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	HOXA7	Homeobox A7. (214 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1252 aa)
	VDR	Vitamin D receptor. (427 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (515 aa)
	M3XW51_MUSPF	Uncharacterized protein. (553 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP27B1	M3YU90_MUSPF	ENSMPUP00000002024	ENSMPUP00000014900	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.541
CYP27B1	VDR	ENSMPUP00000002024	ENSMPUP00000000416	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Vitamin D receptor.	0.769
CYP27C1	M3YU90_MUSPF	ENSMPUP00000011934	ENSMPUP00000014900	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.541
ETV4	NCOA3	ENSMPUP00000009615	ENSMPUP00000017480	ETS variant 4.	Nuclear receptor coactivator.	0.934
EZH2	MACROH2A1	ENSMPUP00000007191	ENSMPUP00000009936	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.600
EZH2	MACROH2A2	ENSMPUP00000007191	ENSMPUP00000004326	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.600
EZH2	NOTCH1	ENSMPUP00000007191	ENSMPUP00000011233	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Notch receptor 1.	0.456
KRT36	KRT84	ENSMPUP00000010905	ENSMPUP00000007164	Keratin 36; Belongs to the intermediate filament family.	Keratin 84; Belongs to the intermediate filament family.	0.439
KRT84	KRT36	ENSMPUP00000007164	ENSMPUP00000010905	Keratin 84; Belongs to the intermediate filament family.	Keratin 36; Belongs to the intermediate filament family.	0.439
M3XW51_MUSPF	NOTCH1	ENSMPUP00000003301	ENSMPUP00000011233	Uncharacterized protein.	Notch receptor 1.	0.459
M3YU90_MUSPF	CYP27B1	ENSMPUP00000014900	ENSMPUP00000002024	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	0.541
M3YU90_MUSPF	CYP27C1	ENSMPUP00000014900	ENSMPUP00000011934	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	0.541
M3YU90_MUSPF	NCOA3	ENSMPUP00000014900	ENSMPUP00000017480	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor coactivator.	0.946
M3YU90_MUSPF	VDR	ENSMPUP00000014900	ENSMPUP00000000416	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Vitamin D receptor.	0.908
MACROH2A1	EZH2	ENSMPUP00000009936	ENSMPUP00000007191	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.600
MACROH2A2	EZH2	ENSMPUP00000004326	ENSMPUP00000007191	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.600
NCOA3	ETV4	ENSMPUP00000017480	ENSMPUP00000009615	Nuclear receptor coactivator.	ETS variant 4.	0.934
NCOA3	M3YU90_MUSPF	ENSMPUP00000017480	ENSMPUP00000014900	Nuclear receptor coactivator.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.946
NCOA3	VDR	ENSMPUP00000017480	ENSMPUP00000000416	Nuclear receptor coactivator.	Vitamin D receptor.	0.729
NOTCH1	EZH2	ENSMPUP00000011233	ENSMPUP00000007191	Notch receptor 1.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.456