(73 nodes) Positive regulation of lymphocyte differentiation network (Mustela putorius)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	CD83	CD83 molecule. (199 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4110 aa)
	M3XQH4_MUSPF	BTB domain-containing protein. (620 aa)
	IL23A	Interleukin 23 subunit alpha. (195 aa)
	IL4I1	Interleukin 4 induced 1. (564 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	EGR3	Early growth response 3. (387 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (937 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (673 aa)
	DUSP10	Dual specificity phosphatase 10. (482 aa)
	HLX	H2.0 like homeobox. (449 aa)
	VSIR	V-set immunoregulatory receptor. (290 aa)
	CCL19	C-C motif chemokine. (108 aa)
	ITPKB	Kinase; Belongs to the inositol phosphokinase (IPK) family. (938 aa)
	M3XZW3_MUSPF	Fibronectin type-III domain-containing protein. (374 aa)
	INPP5D	Inositol polyphosphate-5-phosphatase D. (1188 aa)
	CBFB	Core-binding factor subunit beta. (182 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1209 aa)
	NCKAP1L	NCK associated protein 1 like. (1134 aa)
	ZBTB7B	Zinc finger and BTB domain containing 7B. (537 aa)
	M3Y484_MUSPF	SH2 domain-containing protein. (468 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (644 aa)
	M3Y653_MUSPF	Protein kinase domain-containing protein. (212 aa)
	TNFSF9	TNF superfamily member 9; Belongs to the tumor necrosis factor family. (244 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
	PIK3R6	Phosphoinositide-3-kinase regulatory subunit 6. (755 aa)
	M3YA49_MUSPF	Uncharacterized protein. (659 aa)
	M3YA60_MUSPF	N-terminal Ras-GEF domain-containing protein. (178 aa)
	LEF1	Lymphoid enhancer binding factor 1. (400 aa)
	ANXA1	Annexin. (345 aa)
	GAS6	Growth arrest specific 6. (541 aa)
	M3YDW1_MUSPF	Interleukin-1. (183 aa)
	M3YE59_MUSPF	HH_signal domain-containing protein. (290 aa)
	FOXO3	Forkhead box O3. (671 aa)
	IL10	Interleukin 10. (220 aa)
	IL7	Interleukin 7. (158 aa)
	PCID2	PCI domain containing 2. (390 aa)
	TOX	Thymocyte selection associated high mobility group box. (526 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1298 aa)
	STAT5A	Signal transducer and activator of transcription. (794 aa)
	STAT5B	Signal transducer and activator of transcription. (691 aa)
	M3YGX4_MUSPF	Uncharacterized protein. (369 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
	ZAP70	Tyrosine-protein kinase. (616 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (803 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
	SOX13	SRY-box transcription factor 13. (615 aa)
	NFKBIZ	NFKB inhibitor zeta. (720 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	IL4R	Interleukin 4 receptor. (805 aa)
	M3YQ14_MUSPF	BZIP domain-containing protein. (346 aa)
	CD74	CD74 molecule. (279 aa)
	FOXP3	Forkhead box P3. (433 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	MYB	MYB proto-oncogene, transcription factor. (649 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	PPP2R3C	Protein phosphatase 2, regulatory subunit B'', gamma. (450 aa)
	GATA3	GATA binding protein 3. (444 aa)
	MALT1	MALT1 paracaspase. (716 aa)
	IHH	Indian hedgehog signaling molecule. (384 aa)
	CD27	CD27 molecule. (263 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
	SASH3	SAM and SH3 domain containing 3. (380 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
	TGFB1	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
	AXL	AXL receptor tyrosine kinase. (887 aa)
	ADA	Adenosine deaminase. (363 aa)
	GLI3	GLI family zinc finger 3. (1585 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	SOCS1	Suppressor of cytokine signaling 1. (216 aa)
	RHOH	Ras homolog family member H. (191 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	IL2	ENSMPUP00000017552	ENSMPUP00000017283	Adenosine deaminase.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.504
AXL	GAS6	ENSMPUP00000017543	ENSMPUP00000009127	AXL receptor tyrosine kinase.	Growth arrest specific 6.	0.991
BCL6	CD27	ENSMPUP00000003385	ENSMPUP00000016804	BCL6 transcription repressor.	CD27 molecule.	0.527
BCL6	FOXP3	ENSMPUP00000003385	ENSMPUP00000013948	BCL6 transcription repressor.	Forkhead box P3.	0.817
BCL6	GATA3	ENSMPUP00000003385	ENSMPUP00000016298	BCL6 transcription repressor.	GATA binding protein 3.	0.568
BCL6	IFNG	ENSMPUP00000003385	ENSMPUP00000017401	BCL6 transcription repressor.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.550
BCL6	IL10	ENSMPUP00000003385	ENSMPUP00000009891	BCL6 transcription repressor.	Interleukin 10.	0.512
BCL6	IL2	ENSMPUP00000003385	ENSMPUP00000017283	BCL6 transcription repressor.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.540
BCL6	M3YQ14_MUSPF	ENSMPUP00000003385	ENSMPUP00000013422	BCL6 transcription repressor.	BZIP domain-containing protein.	0.748
BCL6	STAT5A	ENSMPUP00000003385	ENSMPUP00000010440	BCL6 transcription repressor.	Signal transducer and activator of transcription.	0.428
CBFB	FOXP3	ENSMPUP00000005323	ENSMPUP00000013948	Core-binding factor subunit beta.	Forkhead box P3.	0.615
CBFB	GATA3	ENSMPUP00000005323	ENSMPUP00000016298	Core-binding factor subunit beta.	GATA binding protein 3.	0.600
CCL19	IFNG	ENSMPUP00000004471	ENSMPUP00000017401	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.582
CCL19	IL10	ENSMPUP00000004471	ENSMPUP00000009891	C-C motif chemokine.	Interleukin 10.	0.524
CCL19	IL2	ENSMPUP00000004471	ENSMPUP00000017283	C-C motif chemokine.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.463
CCL19	IL7	ENSMPUP00000004471	ENSMPUP00000009991	C-C motif chemokine.	Interleukin 7.	0.522
CCL19	PTPRC	ENSMPUP00000004471	ENSMPUP00000010371	C-C motif chemokine.	Protein tyrosine phosphatase receptor type C.	0.418
CD27	BCL6	ENSMPUP00000016804	ENSMPUP00000003385	CD27 molecule.	BCL6 transcription repressor.	0.527
CD27	CD83	ENSMPUP00000016804	ENSMPUP00000000702	CD27 molecule.	CD83 molecule.	0.470
CD27	FOXP3	ENSMPUP00000016804	ENSMPUP00000013948	CD27 molecule.	Forkhead box P3.	0.639