STRINGSTRING
TGFB3 TGFB3 CASP10 CASP10 CASP8 CASP8 TNFAIP6 TNFAIP6 RIPK1 RIPK1 CREB1 CREB1 PIAS3 PIAS3 NEDD9 NEDD9 PTK2B PTK2B GABPA GABPA PRKDC PRKDC TNFRSF11B TNFRSF11B RNF41 RNF41 TRIB1 TRIB1 MYC MYC IL23A IL23A NOTCH2 NOTCH2 RB1 RB1 CD101 CD101 TNFSF11 TNFSF11 PRMT1 PRMT1 M3XTK1_MUSPF M3XTK1_MUSPF BRD1 BRD1 RCOR1 RCOR1 TESC TESC THPO THPO ADIPOQ ADIPOQ PRXL2A PRXL2A CSF1 CSF1 ZBTB16 ZBTB16 CNOT4 CNOT4 PTPN2 PTPN2 ITPKB ITPKB CDC73 CDC73 GPR55 GPR55 FBXW9 FBXW9 FADD FADD HOXA5 HOXA5 HOXA7 HOXA7 M3Y0B9_MUSPF M3Y0B9_MUSPF HCLS1 HCLS1 INPP5D INPP5D NCKAP1L NCKAP1L UBASH3B UBASH3B M3Y377_MUSPF M3Y377_MUSPF RARG RARG SMAP1 SMAP1 MEIS1 MEIS1 FAM210B FAM210B HIF1A HIF1A JAG1 JAG1 HSF1 HSF1 POU4F2 POU4F2 DLL1 DLL1 ZFP36L1 ZFP36L1 FBXW7 FBXW7 KITLG KITLG LEO1 LEO1 ACVR1B ACVR1B M3Y8U3_MUSPF M3Y8U3_MUSPF NDFIP1 NDFIP1 MEF2C MEF2C MEIS2 MEIS2 M3YA03_MUSPF M3YA03_MUSPF CDK6 CDK6 ETS1 ETS1 RASSF2 RASSF2 ZBTB46 ZBTB46 LEF1 LEF1 IL17A IL17A FOS FOS SLC9B2 SLC9B2 CLDN18 CLDN18 HSPA9 HSPA9 PPP3CA PPP3CA FSTL3 FSTL3 FOXO3 FOXO3 CUL4A CUL4A IL34 IL34 LYN LYN STAT3 STAT3 STAT5A STAT5A STAT5B STAT5B TMEM178A TMEM178A M3YGX4_MUSPF M3YGX4_MUSPF B2M B2M FSHR FSHR WDR61 WDR61 TMEM64 TMEM64 IAPP IAPP TNF TNF TRAF6 TRAF6 FBN1 FBN1 RAB7B RAB7B RHEX RHEX ABCB10 ABCB10 TAL1 TAL1 STAT1 STAT1 RBFOX2 RBFOX2 PLA2G3 PLA2G3 CTR9 CTR9 ANKRD54 ANKRD54 GPR137 GPR137 LOX LOX APCS APCS CRP CRP LIF LIF FAXDC2 FAXDC2 TREM2 TREM2 GATA1 GATA1 TREML1 TREML1 CD74 CD74 TFE3 TFE3 TCTA TCTA ISG15 ISG15 SCIN SCIN PPARGC1B PPARGC1B NF1 NF1 PRKCA PRKCA PIK3R1 PIK3R1 CSF3R CSF3R CSF3 CSF3 M3YU65_MUSPF M3YU65_MUSPF M3YU90_MUSPF M3YU90_MUSPF DCSTAMP DCSTAMP KLF10 KLF10 LTF LTF HOXB8 HOXB8 KAT7 KAT7 FES FES CIB1 CIB1 PITHD1 PITHD1 C1QC C1QC NFKBIA NFKBIA MTOR MTOR CD4 CD4 LDB1 LDB1 MITF MITF FOXP1 FOXP1 IFNG IFNG TGFB1 TGFB1 ZFP36 ZFP36 PAF1 PAF1 EIF6 EIF6 INHBA INHBA LRRC17 LRRC17 GPR171 GPR171 CEBPB CEBPB EVI2B EVI2B TOB2 TOB2 GPR68 GPR68
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (545 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (484 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (646 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PIAS3Protein inhibitor of activated STAT 3. (634 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (835 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
GABPAGA binding protein transcription factor subunit alpha. (454 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4110 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
RNF41Ring finger protein 41. (317 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
MYCV-myc myelocytomatosis viral oncoprotein-like protein. (453 aa)
IL23AInterleukin 23 subunit alpha. (195 aa)
NOTCH2Notch receptor 2. (2471 aa)
RB1RB transcriptional corepressor 1. (948 aa)
CD101CD101 molecule. (934 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (374 aa)
M3XTK1_MUSPFUncharacterized protein. (44 aa)
BRD1Bromodomain containing 1. (1188 aa)
RCOR1REST corepressor 1. (376 aa)
TESCTescalcin. (214 aa)
THPOThrombopoietin. (325 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
PRXL2APeroxiredoxin like 2A. (229 aa)
CSF1Colony stimulating factor 1. (517 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
CNOT4CCR4-NOT transcription complex subunit 4. (710 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (388 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (938 aa)
CDC73Cell division cycle 73. (531 aa)
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (329 aa)
FBXW9F-box and WD repeat domain containing 9. (459 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (216 aa)
HOXA5Homeobox A5. (270 aa)
HOXA7Homeobox A7. (214 aa)
M3Y0B9_MUSPFHomeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (271 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (474 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1188 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
M3Y377_MUSPFNTR domain-containing protein. (233 aa)
RARGRetinoic acid receptor gamma. (458 aa)
SMAP1Small ArfGAP 1. (471 aa)
MEIS1Meis homeobox 1. (390 aa)
FAM210BFamily with sequence similarity 210 member B. (192 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (824 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
HSF1Heat shock transcription factor 1. (555 aa)
POU4F2POU domain protein. (408 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (602 aa)
ZFP36L1ZFP36 ring finger protein like 1. (317 aa)
FBXW7F-box and WD repeat domain containing 7. (708 aa)
KITLGKIT ligand. (274 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (664 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (494 aa)
M3Y8U3_MUSPFUncharacterized protein. (114 aa)
NDFIP1Nedd4 family interacting protein 1. (211 aa)
MEF2CMyocyte enhancer factor 2C. (433 aa)
MEIS2Meis homeobox 2. (400 aa)
M3YA03_MUSPFUncharacterized protein. (666 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
ETS1ETS proto-oncogene 1, transcription factor. (443 aa)
RASSF2Ras association domain family member 2. (326 aa)
ZBTB46Zinc finger and BTB domain containing 46. (590 aa)
LEF1Lymphoid enhancer binding factor 1. (400 aa)
IL17AInterleukin 17A. (153 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
SLC9B2Solute carrier family 9 member B2. (538 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (259 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
FSTL3Follistatin like 3. (260 aa)
FOXO3Forkhead box O3. (671 aa)
CUL4ACullin 4A; Belongs to the cullin family. (713 aa)
IL34Interleukin 34. (236 aa)
LYNTyrosine-protein kinase. (512 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT5BSignal transducer and activator of transcription. (691 aa)
TMEM178ATransmembrane protein 178A. (297 aa)
M3YGX4_MUSPFUncharacterized protein. (369 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (128 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (692 aa)
WDR61WD repeat domain 61. (305 aa)
TMEM64Transmembrane protein 64. (285 aa)
IAPPIslet amyloid polypeptide. (89 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
FBN1Fibrillin 1. (2877 aa)
RAB7BRAB7B, member RAS oncogene family. (200 aa)
RHEXRegulator of hemoglobinization and erythroid cell expansion. (173 aa)
ABCB10ATP binding cassette subfamily B member 10. (566 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (346 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
RBFOX2RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events. (403 aa)
PLA2G3Phospholipase A2 group III. (510 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
ANKRD54Ankyrin repeat domain 54. (299 aa)
GPR137G protein-coupled receptor 137. (485 aa)
LOXLysyl oxidase. (415 aa)
APCSPentaxin. (224 aa)
CRPPentaxin. (221 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
FAXDC2Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (334 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
GATA1GATA binding protein 1. (414 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (314 aa)
CD74CD74 molecule. (279 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (572 aa)
TCTAT-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (106 aa)
ISG15ISG15 ubiquitin like modifier. (184 aa)
SCINScinderin. (715 aa)
PPARGC1BPPARG coactivator 1 beta. (1027 aa)
NF1Neurofibromin 1. (2815 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
CSF3RColony stimulating factor 3 receptor. (839 aa)
CSF3Colony stimulating factor 3. (204 aa)
M3YU65_MUSPFC-C motif chemokine. (93 aa)
M3YU90_MUSPFMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (616 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (440 aa)
KLF10Kruppel like factor 10. (480 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
HOXB8Homeobox B8. (243 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (583 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (820 aa)
CIB1Calcium and integrin binding 1. (187 aa)
PITHD1PITH domain containing 1. (211 aa)
C1QCComplement C1q C chain. (278 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
CD4CD4. (462 aa)
LDB1LIM domain binding 1. (411 aa)
MITFMelanocyte inducing transcription factor. (520 aa)
FOXP1Forkhead box P1. (676 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
ZFP36ZFP36 ring finger protein. (327 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (554 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
INHBAInhibin subunit beta A. (424 aa)
LRRC17Leucine rich repeat containing 17. (438 aa)
GPR171G protein-coupled receptor 171. (318 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
EVI2BEcotropic viral integration site 2B. (455 aa)
TOB2Transducer of ERBB2, 2. (339 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (360 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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