(21 nodes) Positive regulation of osteoclast differentiation network (Mustela putorius)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	IL17A	Interleukin 17A. (153 aa)
	POU4F2	POU domain protein. (408 aa)
	CSF1	Colony stimulating factor 1. (517 aa)
	M3XTK1_MUSPF	Uncharacterized protein. (44 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
	NOTCH2	Notch receptor 2. (2471 aa)
	IL23A	Interleukin 23 subunit alpha. (195 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (835 aa)
	GPR68	G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
	KLF10	Kruppel like factor 10. (480 aa)
	PPARGC1B	PPARG coactivator 1 beta. (1027 aa)
	TREML1	Triggering receptor expressed on myeloid cells like 1. (314 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	TMEM64	Transmembrane protein 64. (285 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (461 aa)
	SLC9B2	Solute carrier family 9 member B2. (538 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (446 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREB1	FOS	ENSMPUP00000000479	ENSMPUP00000009076	cAMP responsive element binding protein 1.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.707
CREB1	IFNG	ENSMPUP00000000479	ENSMPUP00000017401	cAMP responsive element binding protein 1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.431
CREB1	TNF	ENSMPUP00000000479	ENSMPUP00000011297	cAMP responsive element binding protein 1.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.534
CSF1	IFNG	ENSMPUP00000003729	ENSMPUP00000017401	Colony stimulating factor 1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.689
CSF1	IL17A	ENSMPUP00000003729	ENSMPUP00000008930	Colony stimulating factor 1.	Interleukin 17A.	0.518
CSF1	TNF	ENSMPUP00000003729	ENSMPUP00000011297	Colony stimulating factor 1.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.670
CSF1	TRAF6	ENSMPUP00000003729	ENSMPUP00000011691	Colony stimulating factor 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.431
CSF1	TREM2	ENSMPUP00000003729	ENSMPUP00000013551	Colony stimulating factor 1.	Triggering receptor expressed on myeloid cells 2.	0.435
CSF1	TREML1	ENSMPUP00000003729	ENSMPUP00000013574	Colony stimulating factor 1.	Triggering receptor expressed on myeloid cells like 1.	0.435
FOS	CREB1	ENSMPUP00000009076	ENSMPUP00000000479	Fos proto-oncogene, AP-1 transcription factor subunit.	cAMP responsive element binding protein 1.	0.707
FOS	TNF	ENSMPUP00000009076	ENSMPUP00000011297	Fos proto-oncogene, AP-1 transcription factor subunit.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.452
IFNG	CREB1	ENSMPUP00000017401	ENSMPUP00000000479	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	cAMP responsive element binding protein 1.	0.431
IFNG	CSF1	ENSMPUP00000017401	ENSMPUP00000003729	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	Colony stimulating factor 1.	0.689
IFNG	IL17A	ENSMPUP00000017401	ENSMPUP00000008930	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	Interleukin 17A.	0.820
IFNG	IL23A	ENSMPUP00000017401	ENSMPUP00000001383	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	Interleukin 23 subunit alpha.	0.673
IFNG	TNF	ENSMPUP00000017401	ENSMPUP00000011297	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.868
IFNG	TRAF6	ENSMPUP00000017401	ENSMPUP00000011691	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.513
IFNG	TREM2	ENSMPUP00000017401	ENSMPUP00000013551	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	Triggering receptor expressed on myeloid cells 2.	0.468
IL17A	CSF1	ENSMPUP00000008930	ENSMPUP00000003729	Interleukin 17A.	Colony stimulating factor 1.	0.518
IL17A	IFNG	ENSMPUP00000008930	ENSMPUP00000017401	Interleukin 17A.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.820