STRINGSTRING
MAPK7 MAPK7 M3XMV4_MUSPF M3XMV4_MUSPF M3XNH8_MUSPF M3XNH8_MUSPF JAK1 JAK1 SEMA6A SEMA6A GAB1 GAB1 PTK2B PTK2B ADAMTS1 ADAMTS1 ENPP2 ENPP2 TBC1D31 TBC1D31 ISM1 ISM1 M3XRQ8_MUSPF M3XRQ8_MUSPF CNMD CNMD AGO2 AGO2 ADGRB1 ADGRB1 TNMD TNMD RRAS RRAS ANGPT2 ANGPT2 VEGFD VEGFD WARS1 WARS1 SARS1 SARS1 CD34 CD34 HRG HRG F3 F3 FUT1 FUT1 HIPK2 HIPK2 PROK1 PROK1 NAXE NAXE AMOT AMOT TGFB2 TGFB2 NODAL NODAL FOXO4 FOXO4 FLT1 FLT1 ECM1 ECM1 SIRT6 SIRT6 SEMA4A SEMA4A HOXA5 HOXA5 TNN TNN THBS4 THBS4 CDH5 CDH5 M3Y0N5_MUSPF M3Y0N5_MUSPF LRG1 LRG1 EMILIN2 EMILIN2 AQP1 AQP1 KDR KDR MYDGF MYDGF PRKD2 PRKD2 CXCR3 CXCR3 PRKD1 PRKD1 ROCK1 ROCK1 SFRP2 SFRP2 M3Y2C5_MUSPF M3Y2C5_MUSPF BMPER BMPER GATA6 GATA6 CREB3L1 CREB3L1 IGF2 IGF2 ADGRB3 ADGRB3 ITGA5 ITGA5 EFNA1 EFNA1 RECK RECK EFNA3 EFNA3 M3Y377_MUSPF M3Y377_MUSPF ITGB1 ITGB1 SP1 SP1 HSPB6 HSPB6 ZNF304 ZNF304 HIF1A HIF1A LEP LEP RHOJ RHOJ SMOC2 SMOC2 THBS2 THBS2 ANXA3 ANXA3 SMAD1 SMAD1 EPHA1 EPHA1 DLL1 DLL1 EPN1 EPN1 TSPAN12 TSPAN12 DAB2IP DAB2IP SYNJ2BP SYNJ2BP BTG1 BTG1 DCN DCN C5 C5 ACVRL1 ACVRL1 PIK3R6 PIK3R6 FGF1 FGF1 EPN2 EPN2 ANGPTL3 ANGPTL3 SPRED1 SPRED1 THBS1 THBS1 S100A1 S100A1 HK2 HK2 M3YAR0_MUSPF M3YAR0_MUSPF ETS1 ETS1 CXCL10 CXCL10 MTDH MTDH RNH1 RNH1 IL17F IL17F GDF2 GDF2 VASH1 VASH1 MECP2 MECP2 PIK3CB PIK3CB M3YCN1_MUSPF M3YCN1_MUSPF CXCL8 CXCL8 PGF PGF EMILIN1 EMILIN1 ALOX5 ALOX5 NR2E1 NR2E1 IL10 IL10 ADGRA2 ADGRA2 RAMP2 RAMP2 CCN6 CCN6 CYP1B1 CYP1B1 PDCD6 PDCD6 STAT3 STAT3 COL4A2 COL4A2 SULF1 SULF1 JUP JUP DDAH2 DDAH2 TLR3 TLR3 TNF TNF HGS HGS GLUL GLUL CHI3L1 CHI3L1 ATP2B4 ATP2B4 SIRT1 SIRT1 VEGFC VEGFC PDCL3 PDCL3 PRKCB PRKCB HMOX1 HMOX1 STAT1 STAT1 ABL1 ABL1 VEGFA VEGFA FGF18 FGF18 SERPINF1 SERPINF1 VEGFB VEGFB PDE3B PDE3B VASH2 VASH2 SPHK1 SPHK1 M3YQ14_MUSPF M3YQ14_MUSPF ENG ENG TIE1 TIE1 HTATIP2 HTATIP2 ITGB8 ITGB8 ATF2 ATF2 NF1 NF1 M3YT63_MUSPF M3YT63_MUSPF APOH APOH PRKCA PRKCA ZC3H12A ZC3H12A PDPK1 PDPK1 ADGRB2 ADGRB2 CTSH CTSH MINAR1 MINAR1 FASLG FASLG SERPINE1 SERPINE1 E2F2 E2F2 TEK TEK HSPB1 HSPB1 CCL24 CCL24 GTF2I GTF2I EPHA2 EPHA2 JCAD JCAD CCBE1 CCBE1 FOXJ2 FOXJ2 STAB1 STAB1 PKM PKM PARP6 PARP6 PLXND1 PLXND1 PML PML FGF2 FGF2 PTGIS PTGIS PAK4 PAK4 ANGPT4 ANGPT4 SASH1 SASH1 SEMA3E SEMA3E FKBPL FKBPL M3Z3T3_MUSPF M3Z3T3_MUSPF SPRY2 SPRY2 APLNR APLNR C5AR1 C5AR1 GREM1 GREM1 CLDN5 CLDN5 C3AR1 C3AR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
M3XMV4_MUSPFUncharacterized protein. (466 aa)
M3XNH8_MUSPFUncharacterized protein. (132 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1031 aa)
GAB1GRB2 associated binding protein 1. (648 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (953 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (940 aa)
TBC1D31TBC1 domain family member 31. (1125 aa)
ISM1Isthmin 1. (464 aa)
M3XRQ8_MUSPFUncharacterized protein. (262 aa)
CNMDChondromodulin. (360 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (852 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1568 aa)
TNMDTenomodulin. (317 aa)
RRASRAS related. (218 aa)
ANGPT2Angiopoietin 2. (495 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
WARS1Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (482 aa)
SARS1Seryl-tRNA synthetase. (513 aa)
CD34CD34 molecule. (385 aa)
HRGHistidine rich glycoprotein. (534 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (411 aa)
HIPK2Homeodomain interacting protein kinase 2. (1165 aa)
PROK1Prokineticin 1. (105 aa)
NAXENAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (287 aa)
AMOTAngiomotin. (1062 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
NODALNodal growth differentiation factor. (348 aa)
FOXO4Forkhead box O4. (509 aa)
FLT1Receptor protein-tyrosine kinase. (1338 aa)
ECM1Extracellular matrix protein 1. (564 aa)
SIRT6Sirtuin 6. (359 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (761 aa)
HOXA5Homeobox A5. (270 aa)
TNNTenascin N. (1472 aa)
THBS4Thrombospondin 4. (964 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
M3Y0N5_MUSPFIg-like domain-containing protein. (341 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (354 aa)
EMILIN2Elastin microfibril interfacer 2. (1076 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
MYDGFMyeloid derived growth factor. (173 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (824 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1252 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
M3Y2C5_MUSPFUncharacterized protein. (716 aa)
BMPERBMP binding endothelial regulator. (685 aa)
GATA6GATA binding protein 6. (482 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
IGF2Insulin like growth factor 2. (192 aa)
ADGRB3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1284 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1104 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (175 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (969 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (193 aa)
M3Y377_MUSPFNTR domain-containing protein. (233 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
SP1Sp1 transcription factor. (787 aa)
HSPB6Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family. (182 aa)
ZNF304Zinc finger protein 304. (668 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (824 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
RHOJRas homolog family member J. (282 aa)
SMOC2SPARC related modular calcium binding 2. (455 aa)
THBS2Thrombospondin 2. (1173 aa)
ANXA3Annexin. (323 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
EPHA1EPH receptor A1. (976 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (602 aa)
EPN1Epsin 1. (569 aa)
TSPAN12Tetraspanin. (305 aa)
DAB2IPDAB2 interacting protein. (1112 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
BTG1BTG anti-proliferation factor 1. (171 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
C5Complement C5. (1678 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (755 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
EPN2Epsin 2. (583 aa)
ANGPTL3Angiopoietin like 3. (422 aa)
SPRED1Sprouty related EVH1 domain containing 1. (443 aa)
THBS1Thrombospondin 1. (1170 aa)
S100A1Protein S100; Belongs to the S-100 family. (142 aa)
HK2Hexokinase 2. (917 aa)
M3YAR0_MUSPFUncharacterized protein. (736 aa)
ETS1ETS proto-oncogene 1, transcription factor. (443 aa)
CXCL10C-X-C motif chemokine. (98 aa)
MTDHMetadherin. (627 aa)
RNH1Ribonuclease/angiogenin inhibitor 1. (433 aa)
IL17FUncharacterized protein. (140 aa)
GDF2Growth differentiation factor 2. (429 aa)
VASH1Vasohibin 1. (363 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (484 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
M3YCN1_MUSPFUncharacterized protein. (223 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
IL10Interleukin 10. (220 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1280 aa)
RAMP2Receptor activity modifying protein 2. (194 aa)
CCN6Cellular communication network factor 6. (358 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (544 aa)
PDCD6Programmed cell death 6. (189 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
COL4A2Collagen type IV alpha 2 chain. (1718 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (867 aa)
JUPJunction plakoglobin. (744 aa)
DDAH2Dimethylarginine dimethylaminohydrolase 2. (288 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (764 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (780 aa)
GLULGlutamine synthetase. (414 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (392 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1206 aa)
SIRT1Sirtuin 1. (557 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (370 aa)
PDCL3Phosducin like 3. (240 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (577 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
PDE3BPhosphodiesterase. (889 aa)
VASH2Vasohibin 2. (344 aa)
SPHK1Sphingosine kinase 1. (386 aa)
M3YQ14_MUSPFBZIP domain-containing protein. (346 aa)
ENGEndoglin. (653 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (994 aa)
HTATIP2HIV-1 Tat interactive protein 2. (242 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
NF1Neurofibromin 1. (2815 aa)
M3YT63_MUSPFUncharacterized protein. (501 aa)
APOHApolipoprotein H. (345 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (576 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
ADGRB2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1493 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (918 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (275 aa)
SERPINE1Serpin peptidase inhibitor, clade E, member 1; Belongs to the serpin family. (400 aa)
E2F2E2F transcription factor 2. (440 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (207 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
GTF2IGeneral transcription factor IIi. (979 aa)
EPHA2EPH receptor A2. (975 aa)
JCADJunctional cadherin 5 associated. (1360 aa)
CCBE1Collagen and calcium binding EGF domains 1. (380 aa)
FOXJ2Forkhead box J2. (567 aa)
STAB1Stabilin 1. (2572 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (579 aa)
PARP6Poly [ADP-ribose] polymerase. (741 aa)
PLXND1Plexin D1. (1746 aa)
PMLPromyelocytic leukemia. (876 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (444 aa)
PAK4Non-specific serine/threonine protein kinase. (592 aa)
ANGPT4Angiopoietin 4. (498 aa)
SASH1SAM and SH3 domain containing 1. (1145 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
FKBPLFKBP prolyl isomerase like. (349 aa)
M3Z3T3_MUSPFUncharacterized protein. (262 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
GREM1Gremlin. (184 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (479 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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