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| | ATRX | ATRX chromatin remodeler. (2784 aa) |
| | DRD3 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (447 aa) |
| | RAB11A | RAB11A, member RAS oncogene family. (216 aa) |
| | CD28 | CD28 molecule. (255 aa) |
| | CCNYL1 | Cyclin Y like 1; Belongs to the cyclin family. (372 aa) |
| | EDN1 | Endothelin 1. (202 aa) |
| | M3XP56_MUSPF | Protein kinase domain-containing protein. (158 aa) |
| | M3XP59_MUSPF | SAM domain-containing protein. (355 aa) |
| | PBK | PDZ binding kinase. (323 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif 1. (953 aa) |
| | MTBP | MDM2 binding protein. (893 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (275 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (1041 aa) |
| | RB1 | RB transcriptional corepressor 1. (948 aa) |
| | ASNS | Asparagine synthetase [glutamine-hydrolyzing]. (561 aa) |
| | GLI1 | GLI family zinc finger 1. (1105 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3466 aa) |
| | NCAPH2 | Non-SMC condensin II complex subunit H2. (555 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (305 aa) |
| | M3XSH0_MUSPF | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (219 aa) |
| | M3XSL4_MUSPF | Uncharacterized protein. (443 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (711 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (598 aa) |
| | CCPG1 | Cell cycle progression 1. (870 aa) |
| | PKD2 | Polycystin 2, transient receptor potential cation channel. (915 aa) |
| | NCAPG | Non-SMC condensin I complex subunit G. (1014 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa) |
| | CCNT2 | Cyclin T2; Belongs to the cyclin family. (759 aa) |
| | TBX3 | T-box transcription factor 3. (757 aa) |
| | GPSM2 | G protein signaling modulator 2. (681 aa) |
| | DYNC1H1 | Dynein cytoplasmic 1 heavy chain 1. (4469 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1288 aa) |
| | CIT | Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2069 aa) |
| | GIPC1 | GIPC PDZ domain containing family member 1. (333 aa) |
| | M3XV89_MUSPF | Uncharacterized protein; Belongs to the cyclin family. (501 aa) |
| | DDX39A | DExD-box helicase 39A. (427 aa) |
| | PSRC1 | Proline and serine rich coiled-coil 1. (327 aa) |
| | NKX3-1 | NK3 homeobox 1. (231 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (283 aa) |
| | PIWIL2 | Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (970 aa) |
| | M3XXC5_MUSPF | Nsp1_C domain-containing protein. (267 aa) |
| | DRD2 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (443 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase, 10. (226 aa) |
| | GIPC3 | GIPC PDZ domain containing family member 3. (252 aa) |
| | NPM2 | Nucleophosmin/nucleoplasmin 2. (221 aa) |
| | ZPR1 | ZPR1 zinc finger. (460 aa) |
| | STRA8 | Stimulated by retinoic acid 8. (451 aa) |
| | M3XYE2_MUSPF | RanBD1 domain-containing protein. (209 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1145 aa) |
| | M3XYN0_MUSPF | Uncharacterized protein. (192 aa) |
| | RAD23A | RAD23 homolog A, nucleotide excision repair protein. (363 aa) |
| | LRP5 | Uncharacterized protein. (1465 aa) |
| | OOEP | Oocyte expressed protein. (149 aa) |
| | CDC7 | Cell division cycle 7. (575 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | STOX1 | Storkhead box 1. (876 aa) |
| | CDC73 | Cell division cycle 73. (531 aa) |
| | PKN2 | Protein kinase N2. (983 aa) |
| | HOXA13 | Homeobox A13. (259 aa) |
| | CXCR5 | C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa) |
| | RHOC | Ras homolog family member C. (193 aa) |
| | DMRT1 | Doublesex and mab-3 related transcription factor 1. (324 aa) |
| | NDC80 | NDC80 kinetochore complex component. (642 aa) |
| | FOXG1 | Forkhead box G1. (424 aa) |
| | THOC1 | THO complex 1. (657 aa) |
| | USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa) |
| | PLRG1 | Pleiotropic regulator 1. (515 aa) |
| | INS | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa) |
| | IGF2 | Insulin like growth factor 2. (192 aa) |
| | M3Y2T5_MUSPF | RAMA domain-containing protein. (491 aa) |
| | BHMG1 | Basic helix-loop-helix and HMG-box containing 1. (584 aa) |
| | TGM1 | Transglutaminase 1. (809 aa) |
| | MARK4 | Microtubule affinity regulating kinase 4. (688 aa) |
| | CCNY | Cyclin Y; Belongs to the cyclin family. (341 aa) |
| | CKS1B | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | M3Y484_MUSPF | SH2 domain-containing protein. (468 aa) |
| | MNAT1 | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa) |
| | M3Y513_MUSPF | Uncharacterized protein. (907 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | SMOC2 | SPARC related modular calcium binding 2. (455 aa) |
| | HSF1 | Heat shock transcription factor 1. (555 aa) |
| | M3Y652_MUSPF | Uncharacterized protein. (633 aa) |
| | M3Y687_MUSPF | Uncharacterized protein. (493 aa) |
| | SMC2 | Structural maintenance of chromosomes protein. (1191 aa) |
| | SMPD3 | Sphingomyelin phosphodiesterase 3. (658 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (753 aa) |
| | TGFA | Transforming growth factor alpha. (158 aa) |
| | RAD51B | RAD51 paralog B. (281 aa) |
| | RAB11B | RAB11B, member RAS oncogene family. (218 aa) |
| | M3Y7A6_MUSPF | Rad51 domain-containing protein. (120 aa) |
| | LGMN | Legumain. (433 aa) |
| | M3Y8U7_MUSPF | CDT1 domain-containing protein. (347 aa) |
| | MSX1 | Msh homeobox 1. (303 aa) |
| | CDC27 | Cell division cycle 27. (825 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (344 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (550 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1352 aa) |
| | CDC25B | Cell division cycle 25B. (515 aa) |
| | INO80 | INO80 complex ATPase subunit. (1561 aa) |
| | M3YBR7_MUSPF | Uncharacterized protein. (441 aa) |
| | MTA3 | Metastasis associated 1 family member 3. (621 aa) |
| | ANXA1 | Annexin. (345 aa) |
| | MECP2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (484 aa) |
| | BTC | Betacellulin. (185 aa) |
| | EREG | Epiregulin. (161 aa) |
| | EPGN | Epithelial mitogen. (153 aa) |
| | CDC16 | Cell division cycle 16. (605 aa) |
| | M3YCR5_MUSPF | Uncharacterized protein. (264 aa) |
| | MEIOC | Meiosis specific with coiled-coil domain. (960 aa) |
| | ANKRD17 | Ankyrin repeat domain 17. (2491 aa) |
| | M3YD44_MUSPF | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa) |
| | SOX15 | SRY-box transcription factor 15. (233 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (255 aa) |
| | MAPRE3 | Microtubule associated protein RP/EB family member 3. (294 aa) |
| | CDC25C | Cell division cycle 25C. (491 aa) |
| | BCL2L11 | BCL2 like 11. (232 aa) |
| | M3YDJ4_MUSPF | Uncharacterized protein. (236 aa) |
| | CDC23 | Cell division cycle 23. (590 aa) |
| | SMC5 | SMC_N domain-containing protein. (1026 aa) |
| | M3YE25_MUSPF | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (153 aa) |
| | TFDP1 | Transcription factor. (410 aa) |
| | NR2E1 | Nuclear receptor subfamily 2 group E member 1. (385 aa) |
| | NCAPG2 | Non-SMC condensin II complex subunit G2. (1138 aa) |
| | EIF4EBP1 | Eukaryotic translation initiation factor 4E binding protein 1. (118 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (713 aa) |
| | IL10 | Interleukin 10. (220 aa) |
| | M3YEZ0_MUSPF | RAD51_interact domain-containing protein. (326 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | DYRK3 | Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa) |
| | BECN1 | Beclin 1. (448 aa) |
| | M3YFG2_MUSPF | GFA domain-containing protein. (169 aa) |
| | CSPP1 | Centrosome and spindle pole associated protein 1. (1177 aa) |
| | PCID2 | PCI domain containing 2. (390 aa) |
| | NUMA1 | Nuclear mitotic apparatus protein 1. (1792 aa) |
| | UBXN2B | UBX domain protein 2B. (330 aa) |
| | KIF14 | Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1662 aa) |
| | RRM1 | Ribonucleotide reductase catalytic subunit M1. (518 aa) |
| | TRIM21 | Tripartite motif containing 21. (468 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | STAT5B | Signal transducer and activator of transcription. (691 aa) |
| | FBXO5 | F-box protein 5. (386 aa) |
| | CEP295 | Centrosomal protein 295. (2448 aa) |
| | GIPC2 | GIPC PDZ domain containing family member 2. (312 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | CCDC57 | Coiled-coil domain containing 57. (841 aa) |
| | FAM178B | Family with sequence similarity 178 member B. (654 aa) |
| | AIF1 | Allograft inflammatory factor 1. (147 aa) |
| | M3YIU0_MUSPF | RING-type domain-containing protein. (84 aa) |
| | DDX39B | DExD-box helicase 39B. (428 aa) |
| | OVOL1 | Ovo like transcriptional repressor 1. (267 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) |
| | LRP6 | LDL receptor related protein 6. (1462 aa) |
| | PPP1R10 | Protein phosphatase 1 regulatory subunit 10. (956 aa) |
| | CRNN | Cornulin. (542 aa) |
| | DYNC1LI1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (524 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1244 aa) |
| | IGF1 | Insulin like growth factor 1. (153 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa) |
| | TPR | Translocated promoter region, nuclear basket protein. (2439 aa) |
| | CDC14A | Cell division cycle 14A. (610 aa) |
| | SASS6 | SAS-6 centriolar assembly protein. (657 aa) |
| | M3YLP8_MUSPF | Uncharacterized protein. (433 aa) |
| | STIL | STIL centriolar assembly protein. (1275 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (662 aa) |
| | ABL1 | Tyrosine-protein kinase. (1150 aa) |
| | SH2B1 | SH2B adaptor protein 1. (757 aa) |
| | MAD2L1BP | MAD2L1 binding protein. (281 aa) |
| | CEP120 | Centrosomal protein 120. (963 aa) |
| | SVIL | Supervillin. (2245 aa) |
| | M3YP02_MUSPF | PCAF_N domain-containing protein. (92 aa) |
| | M3YP04_MUSPF | Uncharacterized protein. (675 aa) |
| | CPSF3 | Cleavage and polyadenylation specific factor 3. (684 aa) |
| | BIRC5 | Baculoviral IAP repeat containing 5. (142 aa) |
| | AFMID | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (307 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (242 aa) |
| | RRM2 | Ribonucleotide reductase regulatory subunit M2. (392 aa) |
| | CENPJ | Centromere protein J. (1360 aa) |
| | THOC5 | THO complex 5. (683 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (294 aa) |
| | PROX1 | Prospero homeobox 1. (737 aa) |
| | LSM11 | Uncharacterized protein. (165 aa) |
| | SPHK1 | Sphingosine kinase 1. (386 aa) |
| | ROCK2 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1389 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (907 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | SLC6A4 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa) |
| | E2F8 | E2F transcription factor 8. (860 aa) |
| | C6orf89 | Chromosome 6 open reading frame 89. (355 aa) |
| | SPAG5 | Sperm associated antigen 5. (1197 aa) |
| | POLDIP2 | DNA polymerase delta interacting protein 2. (368 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa) |
| | RACGAP1 | Rac GTPase activating protein 1. (631 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1892 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | CCNT1 | Cyclin T1; Belongs to the cyclin family. (727 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa) |
| | M3YU10_MUSPF | RRM domain-containing protein. (311 aa) |
| | CDC25A | Cell division cycle 25A. (476 aa) |
| | M3YU90_MUSPF | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (616 aa) |
| | KLHL18 | Kelch like family member 18. (574 aa) |
| | TBX2 | T-box transcription factor 2. (679 aa) |
| | RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | RAD51C | RAD51 paralog C. (371 aa) |
| | STXBP4 | Syntaxin binding protein 4. (522 aa) |
| | PKD1 | Polycystin 1, transient receptor potential channel interacting. (4230 aa) |
| | MEPCE | Methylphosphate capping enzyme. (693 aa) |
| | PPP1R35 | Protein phosphatase 1 regulatory subunit 35. (305 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U. (592 aa) |
| | DTL | Denticleless E3 ubiquitin protein ligase homolog. (730 aa) |
| | M3YX33_MUSPF | Uncharacterized protein. (191 aa) |
| | RCC2 | Regulator of chromosome condensation 2. (427 aa) |
| | FOXA1 | Forkhead box A1. (501 aa) |
| | FBXO42 | F-box protein 42. (717 aa) |
| | VPS4B | Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (422 aa) |
| | M3YYT7_MUSPF | Uncharacterized protein. (284 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (746 aa) |
| | NANOG | Homeobox domain-containing protein. (310 aa) |
| | PHB2 | Prohibitin. (299 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1173 aa) |
| | ECT2 | Epithelial cell transforming 2. (914 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1550 aa) |
| | PLK4 | Polo like kinase 4. (968 aa) |
| | MAD2L1 | Mitotic arrest deficient 2 like 1. (205 aa) |
| | E2F7 | E2F transcription factor 7. (899 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa) |
| | M3Z1P4_MUSPF | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (181 aa) |
| | FAM83D | Family with sequence similarity 83 member D. (621 aa) |
| | PAF1 | PAF1 homolog, Paf1/RNA polymerase II complex component. (554 aa) |
| | SIRT2 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (412 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (737 aa) |
| | M3Z2L9_MUSPF | Uncharacterized protein. (199 aa) |
| | NSFL1C | NSFL1 cofactor. (370 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1207 aa) |
| | KMT2E | Lysine methyltransferase 2E. (1860 aa) |
| | DBF4 | DBF4 zinc finger. (683 aa) |
| | M3Z432_MUSPF | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | LSM10 | LSM10, U7 small nuclear RNA associated. (123 aa) |
| | M3Z4Q9_MUSPF | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | TRIM32 | Tripartite motif containing 32. (673 aa) |
| | M3Z4V0_MUSPF | RanBD1 domain-containing protein. (208 aa) |
| | M3Z575_MUSPF | UBIQUITIN_CONJUGAT_2 domain-containing protein. (179 aa) |
| | CITED2 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa) |
| | M3Z5C9_MUSPF | UBIQUITIN_CONJUGAT_2 domain-containing protein. (179 aa) |
| | M3Z5K9_MUSPF | GFA domain-containing protein. (261 aa) |
| | M3Z5V4_MUSPF | RanBD1 domain-containing protein. (209 aa) |
| | M3Z5X1_MUSPF | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa) |
| | ZBED6 | Zinc finger BED-type containing 6. (980 aa) |
| | NUP62 | Nucleoporin 62. (527 aa) |
| | RHOB | Ras homolog family member B. (196 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator. (307 aa) |
| | MAP10 | Microtubule associated protein 10. (848 aa) |
| | HSPA2 | Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (635 aa) |
| | NEUROG1 | Neurogenin 1. (247 aa) |
| | MBLAC1 | Metallo-beta-lactamase domain containing 1. (248 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
