STRINGSTRING
SREBF1 SREBF1 VAV3 VAV3 ABCD2 ABCD2 ZBTB20 ZBTB20 CREB1 CREB1 BMP6 BMP6 PTK2B PTK2B SCARB1 SCARB1 HTR2A HTR2A LOC101681938 LOC101681938 NR1H2 NR1H2 AKT1 AKT1 M3XV19_MUSPF M3XV19_MUSPF CNEP1R1 CNEP1R1 SIRT4 SIRT4 NOD2 NOD2 ADIPOQ ADIPOQ PPARD PPARD SPHK2 SPHK2 APOA1 APOA1 CCL19 CCL19 CCL21 CCL21 FLT1 FLT1 STOML2 STOML2 HTR2B HTR2B NR1H3 NR1H3 GPLD1 GPLD1 PLIN5 PLIN5 ABCG4 ABCG4 F2 F2 CD81 CD81 CCN1 CCN1 AMBRA1 AMBRA1 DGKZ DGKZ IGF2 IGF2 LDLR LDLR ATG14 ATG14 PDGFRA PDGFRA M3Y3L0_MUSPF M3Y3L0_MUSPF FGF1 FGF1 ANGPTL3 ANGPTL3 RETN RETN ABCD1 ABCD1 ELOVL5 ELOVL5 ANXA1 ANXA1 TGFB3 TGFB3 PNPLA2 PNPLA2 MLYCD MLYCD CGA CGA LYN LYN CTDNEP1 CTDNEP1 FGFR3 FGFR3 TNF TNF NR1H4 NR1H4 KAT5 KAT5 CREBL2 CREBL2 SLC45A3 SLC45A3 PRKCE PRKCE VAV2 VAV2 ADGRF5 ADGRF5 STARD4 STARD4 PLA2G3 PLA2G3 CD19 CD19 ABHD5 ABHD5 PLA2G6 PLA2G6 PDGFB PDGFB CD74 CD74 PDGFRB PDGFRB MFSD2A MFSD2A NR1D1 NR1D1 SCAP SCAP M3YV14_MUSPF M3YV14_MUSPF FGR FGR AKT3 AKT3 LPGAT1 LPGAT1 SLC27A1 SLC27A1 TEK TEK EPHA8 EPHA8 MLXIPL MLXIPL PPARA PPARA DISP3 DISP3 MTOR MTOR DAGLB DAGLB ACSL3 ACSL3 ABHD6 ABHD6 PPARG PPARG FGF2 FGF2 IFNG IFNG TGFB1 TGFB1 AKT2 AKT2 MID1IP1 MID1IP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
ABCD2ATP binding cassette subfamily D member 2. (742 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
BMP6Bone morphogenetic protein 6. (426 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
LOC101681938Protein kinase domain-containing protein. (490 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (460 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
M3XV19_MUSPFUncharacterized protein. (123 aa)
CNEP1R1CTD nuclear envelope phosphatase 1 regulatory subunit 1. (125 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
PPARDPeroxisome proliferator activated receptor delta. (366 aa)
SPHK2Sphingosine kinase 2. (673 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (323 aa)
CCL19C-C motif chemokine. (108 aa)
CCL21SCY domain-containing protein. (137 aa)
FLT1Receptor protein-tyrosine kinase. (1338 aa)
STOML2Stomatin like 2. (356 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (447 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (875 aa)
PLIN5Perilipin; Belongs to the perilipin family. (480 aa)
ABCG4ATP binding cassette subfamily G member 4. (646 aa)
F2Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (602 aa)
CD81Tetraspanin. (287 aa)
CCN1Cellular communication network factor 1. (382 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1209 aa)
DGKZDiacylglycerol kinase. (934 aa)
IGF2Insulin like growth factor 2. (192 aa)
LDLRLow density lipoprotein receptor. (856 aa)
ATG14Autophagy related 14. (467 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
M3Y3L0_MUSPFUncharacterized protein. (99 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ANGPTL3Angiopoietin like 3. (422 aa)
RETNResistin. (110 aa)
ABCD1ATP binding cassette subfamily D member 1. (733 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (352 aa)
ANXA1Annexin. (345 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
PNPLA2Patatin like phospholipase domain containing 2. (482 aa)
MLYCDMalonyl-CoA decarboxylase. (316 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
LYNTyrosine-protein kinase. (512 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
FGFR3Fibroblast growth factor receptor. (802 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (472 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
CREBL2cAMP responsive element binding protein like 2. (120 aa)
SLC45A3Solute carrier family 45 member 3. (552 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
VAV2Vav guanine nucleotide exchange factor 2. (834 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1386 aa)
STARD4StAR related lipid transfer domain containing 4. (179 aa)
PLA2G3Phospholipase A2 group III. (510 aa)
CD19CD19 molecule. (560 aa)
ABHD5Abhydrolase domain containing 5. (349 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (242 aa)
CD74CD74 molecule. (279 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1137 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (529 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
SCAPSREBF chaperone. (1278 aa)
M3YV14_MUSPFGLUCAGON domain-containing protein. (125 aa)
FGRTyrosine-protein kinase. (526 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (370 aa)
SLC27A1Solute carrier family 27 member 1. (646 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
EPHA8EPH receptor A8. (930 aa)
MLXIPLMLX interacting protein like. (857 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
DISP3Dispatched RND transporter family member 3. (1394 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
DAGLBDiacylglycerol lipase beta. (713 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
ABHD6Abhydrolase domain containing 6. (337 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MID1IP1MID1 interacting protein 1. (183 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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