STRINGSTRING
FLCN FLCN SERPINA12 SERPINA12 ACTN3 ACTN3 TGFB1 TGFB1 GCK GCK CRY1 CRY1 INPP5K INPP5K MST1 MST1 GIT1 GIT1 C1QTNF12 C1QTNF12 ENPP1 ENPP1 TGFB3 TGFB3 M3YUN0_MUSPF M3YUN0_MUSPF CLTC CLTC COX11 COX11 IER3 IER3 STAT3 STAT3 NCOR1 NCOR1 M3YE86_MUSPF M3YE86_MUSPF SLC4A1 SLC4A1 TIGAR TIGAR EP300 EP300 TP53 TP53 MIDN MIDN CBFA2T3 CBFA2T3 SMPD3 SMPD3 FAM3C FAM3C FBP1 FBP1 INS INS SIRT6 SIRT6 M3XZR5_MUSPF M3XZR5_MUSPF M3XZQ7_MUSPF M3XZQ7_MUSPF DDIT4 DDIT4 CLTCL1 CLTCL1 ADIPOQ ADIPOQ AP2A1 AP2A1 LEPR LEPR PASK PASK HDAC4 HDAC4 ERFE ERFE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (414 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (904 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
GCKPhosphotransferase. (473 aa)
CRY1Cryptochrome circadian regulator 1. (587 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (473 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (711 aa)
GIT1GIT ArfGAP 1. (708 aa)
C1QTNF12C1q and TNF related 12. (305 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (847 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
M3YUN0_MUSPFC1q domain-containing protein. (306 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
COX11Cytochrome c oxidase copper chaperone COX11. (279 aa)
IER3Immediate early response 3. (155 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
NCOR1Nuclear receptor corepressor 1. (2510 aa)
M3YE86_MUSPFUncharacterized protein. (766 aa)
SLC4A1Anion exchange protein. (924 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
EP300E1A binding protein p300. (2425 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
MIDNMidnolin. (460 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (630 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
SIRT6Sirtuin 6. (359 aa)
M3XZR5_MUSPFRBR-type E3 ubiquitin transferase. (115 aa)
M3XZQ7_MUSPFUbiquitin-like domain-containing protein. (311 aa)
DDIT4DNA damage inducible transcript 4. (230 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1665 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
LEPRLeptin receptor. (1164 aa)
PASKPAS domain containing serine/threonine kinase. (1341 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
ERFEErythroferrone. (402 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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