(67 nodes) Positive regulation of hormone secretion network (Mustela putorius)

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Your Input:
	FFAR4	Free fatty acid receptor 4. (361 aa)
	TRH	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (246 aa)
	GHRH	Growth hormone releasing hormone. (104 aa)
	GCK	Phosphotransferase. (473 aa)
	SRI	Sorcin. (198 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	INHBB	Inhibin subunit beta B. (238 aa)
	CAPN10	Calpain 10; Belongs to the peptidase C2 family. (665 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	GCG	Glucagon. (180 aa)
	EDN1	Endothelin 1. (202 aa)
	AACS	Acetoacetyl-CoA synthetase. (729 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
	BLK	Tyrosine-protein kinase. (500 aa)
	TCF7L2	Transcription factor 7 like 2. (514 aa)
	M3XSG3_MUSPF	CTNNB1_binding domain-containing protein. (169 aa)
	SPP1	Secreted phosphoprotein 1. (272 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	M3XU21_MUSPF	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (129 aa)
	NKX3-1	NK3 homeobox 1. (231 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (479 aa)
	DRD2	D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (443 aa)
	MCU	Mitochondrial calcium uniporter. (350 aa)
	SNX4	Sorting nexin 4. (450 aa)
	ANO1	Anoctamin. (888 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (875 aa)
	ILDR1	Immunoglobulin like domain containing receptor 1. (546 aa)
	SOX4	SRY-box transcription factor 4. (269 aa)
	PDX1	Pancreatic and duodenal homeobox 1. (283 aa)
	GHRHR	Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
	C2CD2L	C2CD2 like. (660 aa)
	ADCYAP1	Adenylate cyclase activating polypeptide 1. (161 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (824 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1484 aa)
	GPR68	G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	HFE	Homeostatic iron regulator; Belongs to the MHC class I family. (403 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	M3YBQ0_MUSPF	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (137 aa)
	VAMP8	Vesicle associated membrane protein 8. (111 aa)
	UCN	Urocortin. (126 aa)
	NLGN2	Neuroligin 2. (661 aa)
	TM7SF3	Transmembrane 7 superfamily member 3. (542 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (844 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (472 aa)
	PRKCE	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
	C1QTNF1	C1q and TNF related 1. (331 aa)
	C1QTNF6	C1q and TNF related 6. (265 aa)
	PLA2G3	Phospholipase A2 group III. (510 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	LRRC8A	Leucine rich repeat containing 8 VRAC subunit A. (810 aa)
	PLA2G6	Phospholipase A2 group VI. (806 aa)
	DOC2B	Double C2 domain beta. (376 aa)
	RPH3AL	Rabphilin 3A like (without C2 domains). (301 aa)
	C1QTNF12	C1q and TNF related 12. (305 aa)
	RFX6	Regulatory factor X6. (928 aa)
	M3YTP8_MUSPF	V-SNARE coiled-coil homology domain-containing protein. (122 aa)
	RASL10B	RAS like family 10 member B. (203 aa)
	M3YUE8_MUSPF	Longin domain-containing protein; Belongs to the synaptobrevin family. (110 aa)
	M3YUN0_MUSPF	C1q domain-containing protein. (306 aa)
	M3YV14_MUSPF	GLUCAGON domain-containing protein. (125 aa)
	NMB	Neuromedin B. (164 aa)
	BAIAP3	BAI1 associated protein 3. (1157 aa)
	M3YXE6_MUSPF	Uncharacterized protein; Belongs to the synaptobrevin family. (220 aa)
	GRP	Gastrin releasing peptide. (147 aa)
	GALR1	Galanin receptor 1; Belongs to the G-protein coupled receptor 1 family. (349 aa)
	TMF1	TATA element modulatory factor 1. (1088 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY8	ADCYAP1	ENSMPUP00000001384	ENSMPUP00000005347	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase activating polypeptide 1.	0.568
ADCYAP1	ADCY8	ENSMPUP00000005347	ENSMPUP00000001384	Adenylate cyclase activating polypeptide 1.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.568
ADCYAP1	CREB1	ENSMPUP00000005347	ENSMPUP00000000479	Adenylate cyclase activating polypeptide 1.	cAMP responsive element binding protein 1.	0.410
ADCYAP1	GCG	ENSMPUP00000005347	ENSMPUP00000000556	Adenylate cyclase activating polypeptide 1.	Glucagon.	0.423
ADCYAP1	GHRH	ENSMPUP00000005347	ENSMPUP00000017651	Adenylate cyclase activating polypeptide 1.	Growth hormone releasing hormone.	0.565
ADCYAP1	GHRHR	ENSMPUP00000005347	ENSMPUP00000005128	Adenylate cyclase activating polypeptide 1.	Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family.	0.731
ADCYAP1	M3YV14_MUSPF	ENSMPUP00000005347	ENSMPUP00000015174	Adenylate cyclase activating polypeptide 1.	GLUCAGON domain-containing protein.	0.752
ANO1	CFTR	ENSMPUP00000004644	ENSMPUP00000007081	Anoctamin.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	0.582
BAD	PPP3CB	ENSMPUP00000012854	ENSMPUP00000003503	BCL2 associated agonist of cell death.	Serine/threonine-protein phosphatase.	0.935
CFTR	ANO1	ENSMPUP00000007081	ENSMPUP00000004644	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Anoctamin.	0.582
CFTR	LRRC8A	ENSMPUP00000007081	ENSMPUP00000012900	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Leucine rich repeat containing 8 VRAC subunit A.	0.431
CFTR	M3YTP8_MUSPF	ENSMPUP00000007081	ENSMPUP00000014708	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	V-SNARE coiled-coil homology domain-containing protein.	0.402
CFTR	M3YUE8_MUSPF	ENSMPUP00000007081	ENSMPUP00000014958	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Longin domain-containing protein; Belongs to the synaptobrevin family.	0.411
CFTR	M3YXE6_MUSPF	ENSMPUP00000007081	ENSMPUP00000016006	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Uncharacterized protein; Belongs to the synaptobrevin family.	0.411
CFTR	VAMP8	ENSMPUP00000007081	ENSMPUP00000008965	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Vesicle associated membrane protein 8.	0.548
CREB1	ADCYAP1	ENSMPUP00000000479	ENSMPUP00000005347	cAMP responsive element binding protein 1.	Adenylate cyclase activating polypeptide 1.	0.410
CREB1	HIF1A	ENSMPUP00000000479	ENSMPUP00000006460	cAMP responsive element binding protein 1.	Hypoxia inducible factor 1 subunit alpha.	0.555
DOC2B	PRKCE	ENSMPUP00000013625	ENSMPUP00000011922	Double C2 domain beta.	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...]	0.416
DOC2B	RPH3AL	ENSMPUP00000013625	ENSMPUP00000013637	Double C2 domain beta.	Rabphilin 3A like (without C2 domains).	0.718
DRD2	EDN1	ENSMPUP00000003847	ENSMPUP00000000674	D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.	Endothelin 1.	0.872