(22 nodes) Fibroblast proliferation network (Mustela putorius)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	M3Z654_MUSPF	Thioredoxin domain-containing protein. (200 aa)
	VEGFD	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
	CKS1B	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	DAZAP1	DAZ associated protein 1. (453 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (597 aa)
	KAT2A	Lysine acetyltransferase 2A. (869 aa)
	INCA1	Inhibitor of CDK, cyclin A1 interacting protein 1. (248 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	COL3A1	Collagen type III alpha 1 chain. (1466 aa)
	DPH1	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (444 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	E2F8	E2F transcription factor 8. (860 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	NF1	Neurofibromin 1. (2815 aa)
	C1QL4	Complement C1q like 4. (259 aa)
	NGFR	Nerve growth factor receptor. (429 aa)
	LZTS2	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa)
	M3Z432_MUSPF	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	LIG4	DNA ligase. (911 aa)
	M3Z4Q9_MUSPF	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV1	ESR1	ENSMPUP00000007166	ENSMPUP00000010404	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.890
CDK1	CKS1B	ENSMPUP00000010967	ENSMPUP00000006117	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.834
CDK1	E2F8	ENSMPUP00000010967	ENSMPUP00000013795	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	E2F transcription factor 8.	0.464
CDK1	ESR1	ENSMPUP00000010967	ENSMPUP00000010404	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.437
CDK1	M3Z432_MUSPF	ENSMPUP00000010967	ENSMPUP00000018344	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.834
CDK1	M3Z4Q9_MUSPF	ENSMPUP00000010967	ENSMPUP00000018571	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.834
CDK1	TP53	ENSMPUP00000010967	ENSMPUP00000008945	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.845
CKS1B	CDK1	ENSMPUP00000006117	ENSMPUP00000010967	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.834
CKS1B	M3Z432_MUSPF	ENSMPUP00000006117	ENSMPUP00000018344	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.728
CKS1B	M3Z4Q9_MUSPF	ENSMPUP00000006117	ENSMPUP00000018571	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.729
E2F8	CDK1	ENSMPUP00000013795	ENSMPUP00000010967	E2F transcription factor 8.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.464
ESR1	CAV1	ENSMPUP00000010404	ENSMPUP00000007166	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.890
ESR1	CDK1	ENSMPUP00000010404	ENSMPUP00000010967	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.437
ESR1	KAT2A	ENSMPUP00000010404	ENSMPUP00000010482	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Lysine acetyltransferase 2A.	0.426
ESR1	TP53	ENSMPUP00000010404	ENSMPUP00000008945	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.846
FGF10	LIF	ENSMPUP00000014301	ENSMPUP00000013116	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	LIF interleukin 6 family cytokine.	0.543
FGF10	NGFR	ENSMPUP00000014301	ENSMPUP00000015274	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Nerve growth factor receptor.	0.862
KAT2A	ESR1	ENSMPUP00000010482	ENSMPUP00000010404	Lysine acetyltransferase 2A.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.426
KAT2A	TP53	ENSMPUP00000010482	ENSMPUP00000008945	Lysine acetyltransferase 2A.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.559
LIF	FGF10	ENSMPUP00000013116	ENSMPUP00000014301	LIF interleukin 6 family cytokine.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.543