STRINGSTRING
NF1 NF1 MED31 MED31 INCA1 INCA1 ESR1 ESR1 DACH1 DACH1 EMD EMD GAS6 GAS6 EREG EREG TP53 TP53 TP53INP1 TP53INP1 WAPL WAPL CDK6 CDK6 MORC3 MORC3 CTC1 CTC1 M3Y9K9_MUSPF M3Y9K9_MUSPF DAB2IP DAB2IP CAV1 CAV1 WNT2 WNT2 M3Y377_MUSPF M3Y377_MUSPF PDGFRA PDGFRA AQP1 AQP1 M3Y103_MUSPF M3Y103_MUSPF CDC73 CDC73 DDR2 DDR2 ZMIZ1 ZMIZ1 M3XVN2_MUSPF M3XVN2_MUSPF PLA2G1B PLA2G1B MED25 MED25 MYC MYC B4GALT7 B4GALT7 FBXO4 FBXO4 C1QL4 C1QL4 WNT1 WNT1 NGFR NGFR IFI30 IFI30 LZTS2 LZTS2 FNDC3B FNDC3B PML PML PAWR PAWR TGFB1 TGFB1 E2F1 E2F1 PDGFA PDGFA FOSL2 FOSL2 G9KG30_MUSPF G9KG30_MUSPF LIG4 LIG4 TRIM32 TRIM32 JUN JUN DHX9 DHX9 IGF1 IGF1 M3YKW3_MUSPF M3YKW3_MUSPF M3YLE1_MUSPF M3YLE1_MUSPF ABL1 ABL1 LIF LIF PDGFB PDGFB SPHK1 SPHK1 CD74 CD74 CDKN1A CDKN1A M3YS01_MUSPF M3YS01_MUSPF ZMPSTE24 ZMPSTE24 NDUFS4 NDUFS4 FGF10 FGF10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NF1Neurofibromin 1. (2815 aa)
MED31Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa)
INCA1Inhibitor of CDK, cyclin A1 interacting protein 1. (248 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (597 aa)
DACH1Dachshund family transcription factor 1. (517 aa)
EMDEmerin. (260 aa)
GAS6Growth arrest specific 6. (541 aa)
EREGEpiregulin. (161 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (239 aa)
WAPLWAPL cohesin release factor. (1196 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
MORC3MORC family CW-type zinc finger 3. (765 aa)
CTC1CST telomere replication complex component 1. (1216 aa)
M3Y9K9_MUSPFIntegrin beta; Belongs to the integrin beta chain family. (645 aa)
DAB2IPDAB2 interacting protein. (1112 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
M3Y377_MUSPFNTR domain-containing protein. (233 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
M3Y103_MUSPFPex2_Pex12 domain-containing protein. (295 aa)
CDC73Cell division cycle 73. (531 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (924 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (937 aa)
M3XVN2_MUSPFUncharacterized protein. (213 aa)
PLA2G1BPhospholipase A(2). (148 aa)
MED25Mediator complex subunit 25. (836 aa)
MYCV-myc myelocytomatosis viral oncoprotein-like protein. (453 aa)
B4GALT7Beta-1,4-galactosyltransferase 7. (327 aa)
FBXO4F-box protein 4. (387 aa)
C1QL4Complement C1q like 4. (259 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
NGFRNerve growth factor receptor. (429 aa)
IFI30IFI30 lysosomal thiol reductase. (252 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa)
FNDC3BFibronectin type III domain containing 3B. (1206 aa)
PMLPromyelocytic leukemia. (876 aa)
PAWRPro-apoptotic WT1 regulator. (360 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
E2F1E2F transcription factor 1. (354 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (287 aa)
G9KG30_MUSPFPeroxisomal membrane protein 3, 35kDa. (305 aa)
LIG4DNA ligase. (911 aa)
TRIM32Tripartite motif containing 32. (673 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
DHX9DExH-box helicase 9. (1200 aa)
IGF1Insulin like growth factor 1. (153 aa)
M3YKW3_MUSPFRING-type domain-containing protein. (326 aa)
M3YLE1_MUSPFUncharacterized protein. (447 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (242 aa)
SPHK1Sphingosine kinase 1. (386 aa)
CD74CD74 molecule. (279 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
M3YS01_MUSPFIg-like domain-containing protein. (306 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
NDUFS4NADH:ubiquinone oxidoreductase subunit S4. (127 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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