(25 nodes) Positive regulation of receptor-mediated endocytosis network (Mustela putorius)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	DAB2	Disabled-like protein 2, mitogen-responsive phosphoprotein. (769 aa)
	BICD1	BICD cargo adaptor 1. (929 aa)
	SGIP1	SH3 domain GRB2 like endophilin interacting protein 1. (828 aa)
	CD63	Tetraspanin. (264 aa)
	CLU	Clusterin; Belongs to the clusterin family. (462 aa)
	CCL19	C-C motif chemokine. (108 aa)
	CBL	Cbl proto-oncogene. (913 aa)
	CLUL1	Clusterin; Belongs to the clusterin family. (465 aa)
	DGKD	Diacylglycerol kinase. (1171 aa)
	M3Y653_MUSPF	Protein kinase domain-containing protein. (212 aa)
	INSR	Tyrosine-protein kinase receptor. (1352 aa)
	HFE	Homeostatic iron regulator; Belongs to the MHC class I family. (403 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (128 aa)
	FMR1	Fragile X mental retardation 1. (615 aa)
	SCYL2	SCY1 like pseudokinase 2. (929 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
	PICK1	Protein interacting with PRKCA 1. (417 aa)
	VTN	SMB domain-containing protein. (470 aa)
	AHI1	Abelson helper integration site 1. (1171 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (309 aa)
	HIP1	Huntingtin interacting protein 1. (916 aa)
	ATAD1	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (361 aa)
	SFRP4	Secreted frizzled related protein 4. (346 aa)
	GREM1	Gremlin. (184 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD1	PICK1	ENSMPUP00000016888	ENSMPUP00000012937	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family.	Protein interacting with PRKCA 1.	0.487
B2M	HFE	ENSMPUP00000010744	ENSMPUP00000008608	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.868
CBL	DAB2	ENSMPUP00000005387	ENSMPUP00000014680	Cbl proto-oncogene.	Disabled-like protein 2, mitogen-responsive phosphoprotein.	0.548
CBL	INSR	ENSMPUP00000005387	ENSMPUP00000008382	Cbl proto-oncogene.	Tyrosine-protein kinase receptor.	0.947
CBL	LDLRAP1	ENSMPUP00000005387	ENSMPUP00000015670	Cbl proto-oncogene.	Low density lipoprotein receptor adaptor protein 1.	0.549
CBL	M3Y653_MUSPF	ENSMPUP00000005387	ENSMPUP00000006804	Cbl proto-oncogene.	Protein kinase domain-containing protein.	0.974
CBL	PLCG2	ENSMPUP00000005387	ENSMPUP00000009167	Cbl proto-oncogene.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.517
CLU	VTN	ENSMPUP00000000898	ENSMPUP00000014197	Clusterin; Belongs to the clusterin family.	SMB domain-containing protein.	0.584
CLUL1	VTN	ENSMPUP00000005390	ENSMPUP00000014197	Clusterin; Belongs to the clusterin family.	SMB domain-containing protein.	0.789
DAB2	CBL	ENSMPUP00000014680	ENSMPUP00000005387	Disabled-like protein 2, mitogen-responsive phosphoprotein.	Cbl proto-oncogene.	0.548
DAB2	LDLRAP1	ENSMPUP00000014680	ENSMPUP00000015670	Disabled-like protein 2, mitogen-responsive phosphoprotein.	Low density lipoprotein receptor adaptor protein 1.	0.929
DAB2	SGIP1	ENSMPUP00000014680	ENSMPUP00000000762	Disabled-like protein 2, mitogen-responsive phosphoprotein.	SH3 domain GRB2 like endophilin interacting protein 1.	0.583
DGKD	PLCG2	ENSMPUP00000005480	ENSMPUP00000009167	Diacylglycerol kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.852
HFE	B2M	ENSMPUP00000008608	ENSMPUP00000010744	Homeostatic iron regulator; Belongs to the MHC class I family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.868
HIP1	SGIP1	ENSMPUP00000015930	ENSMPUP00000000762	Huntingtin interacting protein 1.	SH3 domain GRB2 like endophilin interacting protein 1.	0.674
INSR	CBL	ENSMPUP00000008382	ENSMPUP00000005387	Tyrosine-protein kinase receptor.	Cbl proto-oncogene.	0.947
INSR	PLCG2	ENSMPUP00000008382	ENSMPUP00000009167	Tyrosine-protein kinase receptor.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.402
INSR	VEGFA	ENSMPUP00000008382	ENSMPUP00000012720	Tyrosine-protein kinase receptor.	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family.	0.861
LDLRAP1	CBL	ENSMPUP00000015670	ENSMPUP00000005387	Low density lipoprotein receptor adaptor protein 1.	Cbl proto-oncogene.	0.549
LDLRAP1	DAB2	ENSMPUP00000015670	ENSMPUP00000014680	Low density lipoprotein receptor adaptor protein 1.	Disabled-like protein 2, mitogen-responsive phosphoprotein.	0.929