(33 nodes) Thymus development network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SRF	Serum response factor. (508 aa)
	M3XMU8_MUSPF	SH3 domain-containing protein. (473 aa)
	PAX1	Paired box 1. (452 aa)
	M3XQH4_MUSPF	BTB domain-containing protein. (620 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (208 aa)
	EPHB3	EPH receptor B3. (959 aa)
	BCL11B	BAF chromatin remodeling complex subunit BCL11B. (585 aa)
	MAPK1	Mitogen-activated protein kinase. (333 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (715 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	HES1	Hes family bHLH transcription factor 1. (283 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (216 aa)
	HOXA3	Homeobox A3. (443 aa)
	M3Y243_MUSPF	zf-C5HC2 domain-containing protein. (128 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1092 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
	SIX4	SIX homeobox 4. (455 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (480 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (644 aa)
	SLC46A2	Solute carrier family 46 member 2. (475 aa)
	CTC1	CST telomere replication complex component 1. (1216 aa)
	BCL2L11	BCL2 like 11. (232 aa)
	AIRE	Autoimmune regulator. (559 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
	ABL1	Tyrosine-protein kinase. (1150 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	FOXN1	Forkhead box N1. (646 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	GATA3	GATA binding protein 3. (444 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
	ASXL1	ASXL transcriptional regulator 1. (1517 aa)
	MAD1L1	Mitotic arrest deficient 1 like 1. (737 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ATM	ENSMPUP00000012584	ENSMPUP00000005920	Tyrosine-protein kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.852
ABL1	CRKL	ENSMPUP00000012584	ENSMPUP00000003600	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.988
ABL1	EPHB3	ENSMPUP00000012584	ENSMPUP00000002839	Tyrosine-protein kinase.	EPH receptor B3.	0.942
ABL1	MAPK1	ENSMPUP00000012584	ENSMPUP00000003112	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.409
ABL1	MAPK3	ENSMPUP00000012584	ENSMPUP00000012543	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.409
AIRE	FOXN1	ENSMPUP00000009956	ENSMPUP00000014157	Autoimmune regulator.	Forkhead box N1.	0.790
ATM	ABL1	ENSMPUP00000005920	ENSMPUP00000012584	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.852
ATM	BRAF	ENSMPUP00000005920	ENSMPUP00000003381	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	B-Raf proto-oncogene, serine/threonine kinase.	0.539
BCL11B	GATA3	ENSMPUP00000003001	ENSMPUP00000016298	BAF chromatin remodeling complex subunit BCL11B.	GATA binding protein 3.	0.511
BCL2L11	MAPK1	ENSMPUP00000009390	ENSMPUP00000003112	BCL2 like 11.	Mitogen-activated protein kinase.	0.943
BCL2L11	MAPK3	ENSMPUP00000009390	ENSMPUP00000012543	BCL2 like 11.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.943
BRAF	ATM	ENSMPUP00000003381	ENSMPUP00000005920	B-Raf proto-oncogene, serine/threonine kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.539
BRAF	MAPK1	ENSMPUP00000003381	ENSMPUP00000003112	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase.	0.868
BRAF	MAPK3	ENSMPUP00000003381	ENSMPUP00000012543	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.856
BRAF	RAF1	ENSMPUP00000003381	ENSMPUP00000017076	B-Raf proto-oncogene, serine/threonine kinase.	Raf-1 proto-oncogene, serine/threonine kinase.	0.992
CRKL	ABL1	ENSMPUP00000003600	ENSMPUP00000012584	CRK like proto-oncogene, adaptor protein.	Tyrosine-protein kinase.	0.988
EPHB3	ABL1	ENSMPUP00000002839	ENSMPUP00000012584	EPH receptor B3.	Tyrosine-protein kinase.	0.942
FOXN1	AIRE	ENSMPUP00000014157	ENSMPUP00000009956	Forkhead box N1.	Autoimmune regulator.	0.790
FOXN1	GATA3	ENSMPUP00000014157	ENSMPUP00000016298	Forkhead box N1.	GATA binding protein 3.	0.583
FOXN1	HOXA3	ENSMPUP00000014157	ENSMPUP00000004690	Forkhead box N1.	Homeobox A3.	0.751