STRINGSTRING
NRP2 NRP2 M3XMZ0_MUSPF M3XMZ0_MUSPF ACVR1 ACVR1 EDN1 EDN1 METTL5 METTL5 SEMA6A SEMA6A EXT1 EXT1 UFL1 UFL1 ZIC3 ZIC3 HAND2 HAND2 M3XSY7_MUSPF M3XSY7_MUSPF M3XSY8_MUSPF M3XSY8_MUSPF FRZB FRZB GBX2 GBX2 ECE2 ECE2 TBX3 TBX3 GSC GSC MAPK1 MAPK1 M3XWE1_MUSPF M3XWE1_MUSPF TP63 TP63 HES1 HES1 MYOCD MYOCD SEMA6C SEMA6C MTF2 MTF2 TGFB2 TGFB2 ALDH1A2 ALDH1A2 EFNB1 EFNB1 SEMA5B SEMA5B FOXO4 FOXO4 HTR2B HTR2B REST REST SEMA4A SEMA4A HOXA7 HOXA7 SETD6 SETD6 SEMA6B SEMA6B M3Y243_MUSPF M3Y243_MUSPF JARID2 JARID2 SFRP2 SFRP2 GATA6 GATA6 M3Y377_MUSPF M3Y377_MUSPF SMO SMO ITGB1 ITGB1 NRP1 NRP1 ERCC2 ERCC2 SP7 SP7 KIT KIT M3Y503_MUSPF M3Y503_MUSPF HIF1A HIF1A JAG1 JAG1 M3Y5E5_MUSPF M3Y5E5_MUSPF EDNRA EDNRA DMRTA2 DMRTA2 EZH2 EZH2 KITLG KITLG PHF19 PHF19 ERBB4 ERBB4 MSX1 MSX1 MEF2C MEF2C CDK6 CDK6 SEMA4F SEMA4F SEMA4D SEMA4D SMAD4 SMAD4 BMPR1A BMPR1A TP53 TP53 BATF BATF WNT8A WNT8A ENSMPUP00000009823 ENSMPUP00000009823 M3YF21_MUSPF M3YF21_MUSPF RDH10 RDH10 PDCD6 PDCD6 PTPRC PTPRC ESR1 ESR1 SOX17 SOX17 ELL3 ELL3 SNAI2 SNAI2 SEMA6D SEMA6D KLHL12 KLHL12 SEMA5A SEMA5A NOTCH1 NOTCH1 SEMA4C SEMA4C LRP6 LRP6 GPM6A GPM6A SHC4 SHC4 TAL1 TAL1 RUNX2 RUNX2 MAPK3 MAPK3 SOX10 SOX10 SRF SRF SEMA3B SEMA3B LIF LIF SEMA3F SEMA3F ANXA6 ANXA6 OSR1 OSR1 OTUD5 OTUD5 M3YQS9_MUSPF M3YQS9_MUSPF HOXD4 HOXD4 SOX9 SOX9 LMBR1L LMBR1L PSMD11 PSMD11 GDNF GDNF M3YU90_MUSPF M3YU90_MUSPF SETD2 SETD2 TBX2 TBX2 NELFB NELFB EPOP EPOP M3YUX6_MUSPF M3YUX6_MUSPF HOXB4 HOXB4 MSI2 MSI2 PEF1 PEF1 PUM1 PUM1 PHACTR4 PHACTR4 SLC9A1 SLC9A1 SEMA4B SEMA4B SOX8 SOX8 FOXA1 FOXA1 PHF5A PHF5A XRCC5 XRCC5 WNT10A WNT10A RADIL RADIL NANOG NANOG SEMA3G SEMA3G M3YZI9_MUSPF M3YZI9_MUSPF NOLC1 NOLC1 SEMA4G SEMA4G KBTBD8 KBTBD8 CYP26C1 CYP26C1 RET RET SEMA7A SEMA7A FGF2 FGF2 M3Z1E7_MUSPF M3Z1E7_MUSPF ZFP36 ZFP36 SEMA3C SEMA3C SEMA3E SEMA3E SEMA3A SEMA3A SEMA3D SEMA3D M3Z3T6_MUSPF M3Z3T6_MUSPF LOC101676600 LOC101676600 CITED2 CITED2 BBS12 BBS12 FZD1 FZD1 ZNF281 ZNF281 GREM1 GREM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
M3XMZ0_MUSPFLisH domain-containing protein. (1132 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
EDN1Endothelin 1. (202 aa)
METTL5Methyltransferase like 5. (209 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1031 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
UFL1UFM1 specific ligase 1. (792 aa)
ZIC3Zic family member 3. (473 aa)
HAND2Heart and neural crest derivatives expressed 2. (208 aa)
M3XSY7_MUSPFUncharacterized protein. (242 aa)
M3XSY8_MUSPFUncharacterized protein. (300 aa)
FRZBFrizzled related protein. (325 aa)
GBX2Gastrulation brain homeobox 2. (325 aa)
ECE2Uncharacterized protein. (883 aa)
TBX3T-box transcription factor 3. (757 aa)
GSCGoosecoid homeobox. (256 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
M3XWE1_MUSPFCoronin; Belongs to the WD repeat coronin family. (474 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (586 aa)
HES1Hes family bHLH transcription factor 1. (283 aa)
MYOCDMyocardin. (980 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (936 aa)
MTF2Metal response element binding transcription factor 2. (593 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
SEMA5BSemaphorin 5B. (1093 aa)
FOXO4Forkhead box O4. (509 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
RESTRE1 silencing transcription factor. (1098 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (761 aa)
HOXA7Homeobox A7. (214 aa)
SETD6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (453 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (690 aa)
M3Y243_MUSPFzf-C5HC2 domain-containing protein. (128 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1092 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
GATA6GATA binding protein 6. (482 aa)
M3Y377_MUSPFNTR domain-containing protein. (233 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (790 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (815 aa)
SP7Sp7 transcription factor. (431 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (948 aa)
M3Y503_MUSPFHomeobox domain-containing protein. (149 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (824 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
M3Y5E5_MUSPFUncharacterized protein. (368 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
DMRTA2DMRT like family A2. (486 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (753 aa)
KITLGKIT ligand. (274 aa)
PHF19PHD finger protein 19. (580 aa)
ERBB4Receptor protein-tyrosine kinase. (1224 aa)
MSX1Msh homeobox 1. (303 aa)
MEF2CMyocyte enhancer factor 2C. (433 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (857 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ENSMPUP00000009823annotation not available (94 aa)
M3YF21_MUSPFPHD-type domain-containing protein. (382 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
PDCD6Programmed cell death 6. (189 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1298 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (597 aa)
SOX17SRY-box transcription factor 17. (406 aa)
ELL3Elongation factor for RNA polymerase II 3. (396 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1082 aa)
KLHL12Kelch like family member 12. (548 aa)
SEMA5ASemaphorin 5A. (1073 aa)
NOTCH1Notch receptor 1. (2119 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (867 aa)
LRP6LDL receptor related protein 6. (1462 aa)
GPM6AGlycoprotein M6A. (278 aa)
SHC4SHC adaptor protein 4. (624 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (346 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (507 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
SOX10SRY-box transcription factor 10. (602 aa)
SRFSerum response factor. (508 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (748 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
ANXA6Annexin. (673 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
OTUD5OTU deubiquitinase 5. (566 aa)
M3YQS9_MUSPFLisH domain-containing protein. (1295 aa)
HOXD4Homeobox D4. (257 aa)
SOX9SRY-box transcription factor 9. (522 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (489 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (452 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
M3YU90_MUSPFMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (616 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2564 aa)
TBX2T-box transcription factor 2. (679 aa)
NELFBNegative elongation factor complex member B. (492 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (369 aa)
M3YUX6_MUSPFUncharacterized protein. (497 aa)
HOXB4Homeobox B4. (251 aa)
MSI2Musashi RNA binding protein 2. (324 aa)
PEF1Penta-EF-hand domain containing 1. (289 aa)
PUM1Pumilio RNA binding family member 1. (1188 aa)
PHACTR4Phosphatase and actin regulator. (708 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (831 aa)
SOX8SRY-box transcription factor 8. (377 aa)
FOXA1Forkhead box A1. (501 aa)
PHF5APHD finger protein 5A. (110 aa)
XRCC5X-ray repair cross complementing 5. (733 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
RADILRap associating with DIL domain. (1050 aa)
NANOGHomeobox domain-containing protein. (310 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (770 aa)
M3YZI9_MUSPFHomeobox domain-containing protein. (197 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (715 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (840 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (519 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1028 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (663 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
M3Z1E7_MUSPFUncharacterized protein. (109 aa)
ZFP36ZFP36 ring finger protein. (327 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
M3Z3T6_MUSPFHomeobox domain-containing protein. (184 aa)
LOC101676600Homeobox domain-containing protein. (185 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
BBS12Bardet-Biedl syndrome 12. (713 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (642 aa)
ZNF281Zinc finger protein 281. (897 aa)
GREM1Gremlin. (184 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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