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CDH13 CDH13 M3XM17_MUSPF M3XM17_MUSPF BMPR2 BMPR2 RREB1 RREB1 FLT4 FLT4 BMP6 BMP6 FGF9 FGF9 MYC MYC NOTCH2 NOTCH2 DLX5 DLX5 DLX6 DLX6 M3XRQ8_MUSPF M3XRQ8_MUSPF AGAP2 AGAP2 TCF7L2 TCF7L2 M3XSG3_MUSPF M3XSG3_MUSPF AKT1 AKT1 ITGA4 ITGA4 WDR48 WDR48 HMX2 HMX2 BMP5 BMP5 NOD2 NOD2 F3 F3 TP63 TP63 CLDN1 CLDN1 EGR3 EGR3 PROK1 PROK1 HLX HLX PTN PTN IQGAP3 IQGAP3 B4GALT1 B4GALT1 NODAL NODAL M3XZP3_MUSPF M3XZP3_MUSPF HTR2B HTR2B ECM1 ECM1 SIRT6 SIRT6 THBS4 THBS4 LRG1 LRG1 PDX1 PDX1 KDR KDR MYDGF MYDGF PRKD2 PRKD2 PRKD1 PRKD1 HSF4 HSF4 BMP4 BMP4 M3Y2C5_MUSPF M3Y2C5_MUSPF M3Y2G4_MUSPF M3Y2G4_MUSPF IGF2 IGF2 M3Y2Z6_MUSPF M3Y2Z6_MUSPF TGM1 TGM1 M3Y377_MUSPF M3Y377_MUSPF SMO SMO SP1 SP1 PIK3CD PIK3CD BMP2 BMP2 ZNF304 ZNF304 TGFBR1 TGFBR1 ESRP2 ESRP2 CDH3 CDH3 WNT2 WNT2 HPN HPN YAP1 YAP1 CAV2 CAV2 TGFA TGFA ACVRL1 ACVRL1 FGF1 FGF1 M3Y9K9_MUSPF M3Y9K9_MUSPF BMPR1A BMPR1A MTA3 MTA3 GDF2 GDF2 PKHD1 PKHD1 EPGN EPGN PGF PGF GRN GRN ODAM ODAM IL10 IL10 ZNF703 ZNF703 PDCD6 PDCD6 STAT3 STAT3 STAT5A STAT5A RTN4 RTN4 VIP VIP EYA1 EYA1 M3YH29_MUSPF M3YH29_MUSPF KDM5B KDM5B EGFL7 EGFL7 NOTCH1 NOTCH1 TNF TNF SIRT1 SIRT1 IGF1 IGF1 VEGFC VEGFC PDCL3 PDCL3 FGF7 FGF7 HMOX1 HMOX1 RUNX2 RUNX2 VEGFA VEGFA BAD BAD VEGFB VEGFB PDGFB PDGFB VASH2 VASH2 PROX1 PROX1 M3YQ14_MUSPF M3YQ14_MUSPF MST1 MST1 OSR1 OSR1 SOX9 SOX9 FGF10 FGF10 NF1 NF1 PRKCA PRKCA TNFAIP3 TNFAIP3 M3YU90_MUSPF M3YU90_MUSPF M3YUJ9_MUSPF M3YUJ9_MUSPF OSR2 OSR2 PDPK1 PDPK1 STXBP4 STXBP4 AKT3 AKT3 CCL24 CCL24 M3YX67_MUSPF M3YX67_MUSPF JCAD JCAD FGF2 FGF2 SRSF6 SRSF6 AKT2 AKT2 EGFR EGFR M3Z3T3_MUSPF M3Z3T3_MUSPF APLNR APLNR FZD7 FZD7 FGFBP1 FGFBP1 C5AR2 C5AR2 C5AR1 C5AR1 SCG2 SCG2 JUN JUN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDH13Cadherin 13. (662 aa)
M3XM17_MUSPFUncharacterized protein. (208 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1045 aa)
RREB1Ras responsive element binding protein 1. (1768 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
BMP6Bone morphogenetic protein 6. (426 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MYCV-myc myelocytomatosis viral oncoprotein-like protein. (453 aa)
NOTCH2Notch receptor 2. (2471 aa)
DLX5Distal-less homeobox 5. (289 aa)
DLX6Distal-less homeobox 6. (250 aa)
M3XRQ8_MUSPFUncharacterized protein. (262 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1172 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
M3XSG3_MUSPFCTNNB1_binding domain-containing protein. (169 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
WDR48WD repeat domain 48. (429 aa)
HMX2H6 family homeobox 2. (272 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (586 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
EGR3Early growth response 3. (387 aa)
PROK1Prokineticin 1. (105 aa)
HLXH2.0 like homeobox. (449 aa)
PTNPleiotrophin. (168 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1610 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (387 aa)
NODALNodal growth differentiation factor. (348 aa)
M3XZP3_MUSPFHMG box domain-containing protein. (215 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
ECM1Extracellular matrix protein 1. (564 aa)
SIRT6Sirtuin 6. (359 aa)
THBS4Thrombospondin 4. (964 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (354 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
MYDGFMyeloid derived growth factor. (173 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (824 aa)
HSF4Heat shock transcription factor 4. (492 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
M3Y2C5_MUSPFUncharacterized protein. (716 aa)
M3Y2G4_MUSPFUncharacterized protein. (50 aa)
IGF2Insulin like growth factor 2. (192 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
TGM1Transglutaminase 1. (809 aa)
M3Y377_MUSPFNTR domain-containing protein. (233 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (790 aa)
SP1Sp1 transcription factor. (787 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
ZNF304Zinc finger protein 304. (668 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (480 aa)
ESRP2Epithelial splicing regulatory protein 2. (661 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (828 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
HPNHepsin; Belongs to the peptidase S1 family. (431 aa)
YAP1Yes associated protein 1. (325 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
TGFATransforming growth factor alpha. (158 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
M3Y9K9_MUSPFIntegrin beta; Belongs to the integrin beta chain family. (645 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
MTA3Metastasis associated 1 family member 3. (621 aa)
GDF2Growth differentiation factor 2. (429 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4056 aa)
EPGNEpithelial mitogen. (153 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
GRNGranulin precursor. (608 aa)
ODAMOdontogenic, ameloblast associated. (273 aa)
IL10Interleukin 10. (220 aa)
ZNF703Zinc finger protein 703. (545 aa)
PDCD6Programmed cell death 6. (189 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
RTN4Reticulon. (986 aa)
VIPVasoactive intestinal peptide. (170 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
KDM5BLysine demethylase 5B. (1691 aa)
EGFL7EGF like domain multiple 7. (277 aa)
NOTCH1Notch receptor 1. (2119 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
SIRT1Sirtuin 1. (557 aa)
IGF1Insulin like growth factor 1. (153 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (370 aa)
PDCL3Phosducin like 3. (240 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (507 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
BADBCL2 associated agonist of cell death. (168 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (242 aa)
VASH2Vasohibin 2. (344 aa)
PROX1Prospero homeobox 1. (737 aa)
M3YQ14_MUSPFBZIP domain-containing protein. (346 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (711 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
SOX9SRY-box transcription factor 9. (522 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
NF1Neurofibromin 1. (2815 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
M3YU90_MUSPFMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (616 aa)
M3YUJ9_MUSPFHMG box domain-containing protein. (171 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
STXBP4Syntaxin binding protein 4. (522 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
M3YX67_MUSPFC-C motif chemokine. (131 aa)
JCADJunctional cadherin 5 associated. (1360 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
SRSF6Serine and arginine rich splicing factor 6. (288 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
M3Z3T3_MUSPFUncharacterized protein. (262 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FGFBP1Fibroblast growth factor binding protein 1. (253 aa)
C5AR2Complement component 5a receptor 2. (337 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
SCG2Secretogranin II. (618 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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