STRINGSTRING
CD80 CD80 SRMS SRMS PTK6 PTK6 M3Y9K9_MUSPF M3Y9K9_MUSPF ERBB4 ERBB4 M3Y8U3_MUSPF M3Y8U3_MUSPF PRKCZ PRKCZ TNFRSF14 TNFRSF14 KITLG KITLG IL31RA IL31RA IL6ST IL6ST IL11 IL11 FBXW7 FBXW7 IL6R IL6R TGFA TGFA CAV1 CAV1 M3Y711_MUSPF M3Y711_MUSPF M3Y653_MUSPF M3Y653_MUSPF M3Y5C0_MUSPF M3Y5C0_MUSPF FGFR1OP FGFR1OP PDGFD PDGFD CASS4 CASS4 LRP8 LRP8 CBLC CBLC KIT KIT M3Y3R7_MUSPF M3Y3R7_MUSPF NRP1 NRP1 M3Y377_MUSPF M3Y377_MUSPF PDGFC PDGFC HPX HPX EFNA1 EFNA1 ITGA5 ITGA5 IGF2 IGF2 M3Y2L0_MUSPF M3Y2L0_MUSPF M3Y2G4_MUSPF M3Y2G4_MUSPF IBTK IBTK SFRP2 SFRP2 CBL CBL CD81 CD81 LRP4 LRP4 ARHGEF2 ARHGEF2 HCLS1 HCLS1 THBS4 THBS4 PARP9 PARP9 FBXW9 FBXW9 AGT AGT CD3E CD3E PTPN2 PTPN2 ARL2BP ARL2BP DMTN DMTN PAK2 PAK2 CLCF1 CLCF1 HES1 HES1 SH2D1B SH2D1B GFRA1 GFRA1 HRG HRG NOD2 NOD2 INPP5F INPP5F PTPN11 PTPN11 M3XSY8_MUSPF M3XSY8_MUSPF M3XSY7_MUSPF M3XSY7_MUSPF BST1 BST1 ADRA2A ADRA2A AFAP1L2 AFAP1L2 SH3BP5 SH3BP5 STAP1 STAP1 HTR2A HTR2A IL23A IL23A SH3BP5L SH3BP5L RACK1 RACK1 ENPP2 ENPP2 ERBB3 ERBB3 PTK2B PTK2B NEDD9 NEDD9 BMP6 BMP6 CNTF CNTF SOCS1 SOCS1 SOCS5 SOCS5 SOCS3 SOCS3 M3Z845_MUSPF M3Z845_MUSPF GREM1 GREM1 SOCS4 SOCS4 PRNP PRNP HGF HGF RELN RELN EGFR EGFR ALK ALK CNOT7 CNOT7 ANGPT4 ANGPT4 SRC SRC PTPN1 PTPN1 IFNG IFNG IL2 IL2 IL21 IL21 CSPG4 CSPG4 TNFRSF1A TNFRSF1A NEURL1 NEURL1 PTPN6 PTPN6 EPHA4 EPHA4 MTOR MTOR NCF1 NCF1 IL15 IL15 TNFSF18 TNFSF18 CRLF1 CRLF1 MLST8 MLST8 SRCIN1 SRCIN1 GGNBP2 GGNBP2 IL22RA2 IL22RA2 RICTOR RICTOR PECAM1 PECAM1 FGF10 FGF10 M3YS97_MUSPF M3YS97_MUSPF VTN VTN UNC119 UNC119 M3YS01_MUSPF M3YS01_MUSPF CSF1R CSF1R CD74 CD74 TSG101 TSG101 TREML1 TREML1 GATA1 GATA1 TREM2 TREM2 IL6 IL6 NF2 NF2 PDGFB PDGFB LIF LIF OSM OSM VEGFA VEGFA ALKAL2 ALKAL2 ABL1 ABL1 FCRL5 FCRL5 MVP MVP TAL1 TAL1 FGF7 FGF7 ABI1 ABI1 PDCL3 PDCL3 M3YKU0_MUSPF M3YKU0_MUSPF PRKCE PRKCE M3YKM8_MUSPF M3YKM8_MUSPF IGF1 IGF1 M3YKM4_MUSPF M3YKM4_MUSPF CHMP6 CHMP6 M3YK20_MUSPF M3YK20_MUSPF CD44 CD44 M3YJF2_MUSPF M3YJF2_MUSPF CSF2 CSF2 ZZEF1 ZZEF1 DGKQ DGKQ FGFR3 FGFR3 ZFYVE28 ZFYVE28 RIPK2 RIPK2 M3YHN2_MUSPF M3YHN2_MUSPF M3YHN1_MUSPF M3YHN1_MUSPF M3YHN0_MUSPF M3YHN0_MUSPF M3YHM6_MUSPF M3YHM6_MUSPF SAMSN1 SAMSN1 M3YGX4_MUSPF M3YGX4_MUSPF EFNA5 EFNA5 DOK7 DOK7 DVL2 DVL2 LYN LYN PTPRC PTPRC NOX4 NOX4 GRM5 GRM5 IL34 IL34 PIBF1 PIBF1 FYN FYN VPS25 VPS25 IL7 IL7 IL20 IL20 CBLB CBLB NCAPG2 NCAPG2 TMEM102 TMEM102 M3YE36_MUSPF M3YE36_MUSPF BANK1 BANK1 ERCC6 ERCC6 PLCG2 PLCG2 GAS6 GAS6 EPGN EPGN EREG EREG AREG AREG BTC BTC TP53 TP53 HBEGF HBEGF SEMA4D SEMA4D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD80CD80 molecule. (302 aa)
SRMSTyrosine-protein kinase. (507 aa)
PTK6Tyrosine-protein kinase. (444 aa)
M3Y9K9_MUSPFIntegrin beta; Belongs to the integrin beta chain family. (645 aa)
ERBB4Receptor protein-tyrosine kinase. (1224 aa)
M3Y8U3_MUSPFUncharacterized protein. (114 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
TNFRSF14TNF receptor superfamily member 14. (286 aa)
KITLGKIT ligand. (274 aa)
IL31RAInterleukin 31 receptor A. (724 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
IL11Interleukin 11. (197 aa)
FBXW7F-box and WD repeat domain containing 7. (708 aa)
IL6RInterleukin 6 receptor. (436 aa)
TGFATransforming growth factor alpha. (158 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
M3Y711_MUSPFacidPPc domain-containing protein. (237 aa)
M3Y653_MUSPFProtein kinase domain-containing protein. (212 aa)
M3Y5C0_MUSPFUncharacterized protein. (147 aa)
FGFR1OPFGFR1 oncogene partner. (345 aa)
PDGFDPlatelet derived growth factor D. (364 aa)
CASS4Cas scaffold protein family member 4. (813 aa)
LRP8LDL receptor related protein 8. (924 aa)
CBLCCbl proto-oncogene C. (516 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (948 aa)
M3Y3R7_MUSPFUncharacterized protein. (144 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
M3Y377_MUSPFNTR domain-containing protein. (233 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
HPXHemopexin. (463 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (175 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1104 aa)
IGF2Insulin like growth factor 2. (192 aa)
M3Y2L0_MUSPFFc of IgG, high affinity Ia, receptor. (352 aa)
M3Y2G4_MUSPFUncharacterized protein. (50 aa)
IBTKInhibitor of Bruton tyrosine kinase. (1352 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
CBLCbl proto-oncogene. (913 aa)
CD81Tetraspanin. (287 aa)
LRP4LDL receptor related protein 4. (1896 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (909 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (474 aa)
THBS4Thrombospondin 4. (964 aa)
PARP9Poly [ADP-ribose] polymerase. (995 aa)
FBXW9F-box and WD repeat domain containing 9. (459 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
CD3ECD3 epsilon antigen. (186 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (388 aa)
ARL2BPADP ribosylation factor like GTPase 2 binding protein. (163 aa)
DMTNDematin actin binding protein. (350 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
CLCF1Cardiotrophin like cytokine factor 1. (281 aa)
HES1Hes family bHLH transcription factor 1. (283 aa)
SH2D1BSH2 domain-containing protein. (143 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (468 aa)
HRGHistidine rich glycoprotein. (534 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1034 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
M3XSY8_MUSPFUncharacterized protein. (300 aa)
M3XSY7_MUSPFUncharacterized protein. (242 aa)
BST1Bone marrow stromal cell antigen 1. (307 aa)
ADRA2AAdrenoceptor alpha 2A; Belongs to the G-protein coupled receptor 1 family. (323 aa)
AFAP1L2Actin filament associated protein 1 like 2. (860 aa)
SH3BP5SH3 domain binding protein 5. (453 aa)
STAP1Signal transducing adaptor family member 1. (287 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
IL23AInterleukin 23 subunit alpha. (195 aa)
SH3BP5LSH3 binding domain protein 5 like. (386 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (317 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (940 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1339 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (835 aa)
BMP6Bone morphogenetic protein 6. (426 aa)
CNTFCiliary neurotrophic factor. (200 aa)
SOCS1Suppressor of cytokine signaling 1. (216 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
M3Z845_MUSPFUncharacterized protein. (307 aa)
GREM1Gremlin. (184 aa)
SOCS4Suppressor of cytokine signaling 4. (441 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (257 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
RELNReelin. (3458 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
ALKTyrosine-protein kinase receptor. (1633 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
ANGPT4Angiopoietin 4. (498 aa)
SRCTyrosine-protein kinase. (536 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (424 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (1951 aa)
TNFRSF1ATNF receptor superfamily member 1A. (501 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
EPHA4EPH receptor A4. (986 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
NCF1Neutrophil cytosolic factor 1. (391 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
TNFSF18TNF superfamily member 18. (173 aa)
CRLF1Cytokine receptor like factor 1. (383 aa)
MLST8MTOR associated protein, LST8 homolog. (328 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1328 aa)
GGNBP2Gametogenetin binding protein 2. (696 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (231 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (739 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
M3YS97_MUSPFUncharacterized protein. (2302 aa)
VTNSMB domain-containing protein. (470 aa)
UNC119Unc-119 lipid binding chaperone. (241 aa)
M3YS01_MUSPFIg-like domain-containing protein. (306 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (978 aa)
CD74CD74 molecule. (279 aa)
TSG101Tumor susceptibility 101. (391 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (314 aa)
GATA1GATA binding protein 1. (414 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
NF2Neurofibromin 2. (591 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (242 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
OSMOncostatin M. (238 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
ALKAL2ALK and LTK ligand 2. (150 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
FCRL5Fc receptor like 5. (892 aa)
MVPMajor vault protein. (998 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (346 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ABI1Abl interactor 1. (507 aa)
PDCL3Phosducin like 3. (240 aa)
M3YKU0_MUSPFUncharacterized protein. (149 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
M3YKM8_MUSPFUncharacterized protein. (172 aa)
IGF1Insulin like growth factor 1. (153 aa)
M3YKM4_MUSPFUncharacterized protein. (52 aa)
CHMP6Charged multivesicular body protein 6. (199 aa)
M3YK20_MUSPFWD_REPEATS_REGION domain-containing protein. (237 aa)
CD44CD44 molecule (Indian blood group). (704 aa)
M3YJF2_MUSPFUncharacterized protein. (140 aa)
CSF2Colony stimulating factor 2. (148 aa)
ZZEF1Zinc finger ZZ-type and EF-hand domain containing 1. (2829 aa)
DGKQDiacylglycerol kinase. (952 aa)
FGFR3Fibroblast growth factor receptor. (802 aa)
ZFYVE28Zinc finger FYVE-type containing 28. (813 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
M3YHN2_MUSPFProtein kinase domain-containing protein. (625 aa)
M3YHN1_MUSPFRoc domain-containing protein. (313 aa)
M3YHN0_MUSPFUncharacterized protein. (221 aa)
M3YHM6_MUSPFANK_REP_REGION domain-containing protein. (264 aa)
SAMSN1SAM domain, SH3 domain and nuclear localization signals 1. (364 aa)
M3YGX4_MUSPFUncharacterized protein. (369 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (260 aa)
DOK7Docking protein 7. (595 aa)
DVL2Dishevelled segment polarity protein 2. (734 aa)
LYNTyrosine-protein kinase. (512 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1298 aa)
NOX4NADPH oxidase 4. (578 aa)
GRM5Glutamate metabotropic receptor 5. (987 aa)
IL34Interleukin 34. (236 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (757 aa)
FYNTyrosine-protein kinase. (537 aa)
VPS25Vacuolar protein sorting 25 homolog. (176 aa)
IL7Interleukin 7. (158 aa)
IL20Interleukin 20. (176 aa)
CBLBCbl proto-oncogene B. (983 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1138 aa)
TMEM102Transmembrane protein 102. (509 aa)
M3YE36_MUSPFUncharacterized protein. (77 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (783 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1482 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
GAS6Growth arrest specific 6. (541 aa)
EPGNEpithelial mitogen. (153 aa)
EREGEpiregulin. (161 aa)
AREGAmphiregulin. (283 aa)
BTCBetacellulin. (185 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (857 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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