(74 nodes) Regulation of phagocytosis network (Mustela putorius)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ALOX15	Arachidonate 15-lipoxygenase. (663 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	M3Z2N1_MUSPF	Uncharacterized protein. (385 aa)
	M3Z2M9_MUSPF	Uncharacterized protein. (288 aa)
	TGM2	Transglutaminase 2. (687 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (672 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	MFGE8	Milk fat globule-EGF factor 8 protein. (470 aa)
	FGR	Tyrosine-protein kinase. (526 aa)
	M3YUJ9_MUSPF	HMG box domain-containing protein. (171 aa)
	APOA2	Apolipoprotein A2. (100 aa)
	FCER1G	Fc fragment of IgE receptor Ig. (86 aa)
	M3YS01_MUSPF	Ig-like domain-containing protein. (306 aa)
	M3YRW9_MUSPF	IGv domain-containing protein. (315 aa)
	TREML1	Triggering receptor expressed on myeloid cells like 1. (314 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	SPHK1	Sphingosine kinase 1. (386 aa)
	COLEC11	Collectin subfamily member 11. (283 aa)
	DOCK2	Dedicator of cytokinesis 2; Belongs to the DOCK family. (1879 aa)
	IL2RB	Interleukin 2 receptor subunit beta. (554 aa)
	TUB	Tubby-like protein; Belongs to the TUB family. (593 aa)
	LMAN2	Lectin, mannose binding 2. (356 aa)
	M3YL16_MUSPF	Fibrinogen C-terminal domain-containing protein. (387 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (660 aa)
	M3YKW1_MUSPF	Fibrinogen C-terminal domain-containing protein. (393 aa)
	M3YK20_MUSPF	WD_REPEATS_REGION domain-containing protein. (237 aa)
	PYCARD	PYD and CARD domain containing. (193 aa)
	M3XM17_MUSPF	Uncharacterized protein. (208 aa)
	M3XML9_MUSPF	Autophagy-related protein 3. (314 aa)
	CAMK1D	Calcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (385 aa)
	COLEC10	Collectin subfamily member 10. (277 aa)
	RACK1	WD_REPEATS_REGION domain-containing protein. (317 aa)
	STAP1	Signal transducing adaptor family member 1. (287 aa)
	RAB27A	RAB27A, member RAS oncogene family. (221 aa)
	PTX3	Pentraxin 3. (381 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1279 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1013 aa)
	AHSG	Alpha 2-HS glycoprotein. (352 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
	SFTPD	Surfactant protein D. (375 aa)
	TULP1	Tubby-like protein; Belongs to the TUB family. (550 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (323 aa)
	M3XZP3_MUSPF	HMG box domain-containing protein. (215 aa)
	SNX12	Sorting nexin 12. (172 aa)
	M3XZW3_MUSPF	Fibronectin type-III domain-containing protein. (374 aa)
	SYT11	Synaptotagmin 11. (431 aa)
	LETMD1	LETM1 domain containing 1. (325 aa)
	M3Y284_MUSPF	Uncharacterized protein. (410 aa)
	M3Y2C8_MUSPF	Uncharacterized protein. (376 aa)
	F2RL1	F2R like trypsin receptor 1. (397 aa)
	M3Y2L0_MUSPF	Fc of IgG, high affinity Ia, receptor. (352 aa)
	NCKAP1L	NCK associated protein 1 like. (1134 aa)
	CLEC7A	C-type lectin domain containing 7A. (248 aa)
	TMEM147	Transmembrane protein 147. (187 aa)
	M3Y653_MUSPF	Protein kinase domain-containing protein. (212 aa)
	M3Y6T5_MUSPF	Autophagy-related protein 3. (293 aa)
	DYSF	Dysferlin. (2133 aa)
	LYAR	Ly1 antibody reactive. (387 aa)
	CYBA	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
	ABCA7	ATP binding cassette subfamily A member 7. (2152 aa)
	CNN2	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (369 aa)
	GAS6	Growth arrest specific 6. (541 aa)
	PIP4P2	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
	MERTK	MER proto-oncogene, tyrosine kinase. (990 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	M3YDS7_MUSPF	Uncharacterized protein. (507 aa)
	M3YDU1_MUSPF	Ig-like domain-containing protein. (169 aa)
	M3YDU6_MUSPF	Uncharacterized protein. (304 aa)
	M3YDV7_MUSPF	Uncharacterized protein. (406 aa)
	SNX3	Sorting nexin 3. (162 aa)
	CD47	CD47 molecule. (306 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1298 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA7	PLCG2	ENSMPUP00000008944	ENSMPUP00000009167	ATP binding cassette subfamily A member 7.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.528
ABCA7	TREM2	ENSMPUP00000008944	ENSMPUP00000013551	ATP binding cassette subfamily A member 7.	Triggering receptor expressed on myeloid cells 2.	0.596
ABCA7	TREML1	ENSMPUP00000008944	ENSMPUP00000013574	ATP binding cassette subfamily A member 7.	Triggering receptor expressed on myeloid cells like 1.	0.596
ADIPOQ	APPL1	ENSMPUP00000003314	ENSMPUP00000016751	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.511
ADIPOQ	APPL2	ENSMPUP00000003314	ENSMPUP00000012020	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.506
ADIPOQ	SFTPD	ENSMPUP00000003314	ENSMPUP00000003557	Adiponectin, C1Q and collagen domain containing.	Surfactant protein D.	0.453
ADIPOQ	TNF	ENSMPUP00000003314	ENSMPUP00000011297	Adiponectin, C1Q and collagen domain containing.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.598
AHSG	APOA2	ENSMPUP00000003190	ENSMPUP00000014233	Alpha 2-HS glycoprotein.	Apolipoprotein A2.	0.913
APOA1	APOA2	ENSMPUP00000004184	ENSMPUP00000014233	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein A2.	0.754
APOA2	AHSG	ENSMPUP00000014233	ENSMPUP00000003190	Apolipoprotein A2.	Alpha 2-HS glycoprotein.	0.913
APOA2	APOA1	ENSMPUP00000014233	ENSMPUP00000004184	Apolipoprotein A2.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.754
APPL1	ADIPOQ	ENSMPUP00000016751	ENSMPUP00000003314	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adiponectin, C1Q and collagen domain containing.	0.511
APPL1	APPL2	ENSMPUP00000016751	ENSMPUP00000012020	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.999
APPL2	ADIPOQ	ENSMPUP00000012020	ENSMPUP00000003314	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adiponectin, C1Q and collagen domain containing.	0.506
APPL2	APPL1	ENSMPUP00000012020	ENSMPUP00000016751	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.999
ATG5	M3XML9_MUSPF	ENSMPUP00000009457	ENSMPUP00000000319	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy-related protein 3.	0.989
ATG5	M3Y6T5_MUSPF	ENSMPUP00000009457	ENSMPUP00000007036	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy-related protein 3.	0.989
ATG5	NOD2	ENSMPUP00000009457	ENSMPUP00000003155	Autophagy protein 5; Involved in autophagic vesicle formation.	Nucleotide binding oligomerization domain containing 2.	0.946
ATG5	TNF	ENSMPUP00000009457	ENSMPUP00000011297	Autophagy protein 5; Involved in autophagic vesicle formation.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.418
CD47	IL15	ENSMPUP00000009839	ENSMPUP00000015989	CD47 molecule.	Interleukin; Belongs to the IL-15/IL-21 family.	0.532