(48 nodes) Regulation of antigen receptor-mediated signaling pathway network (Mustela putorius)

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Your Input:
	LPXN	Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (414 aa)
	M3XNH8_MUSPF	Uncharacterized protein. (132 aa)
	M3XP26_MUSPF	Uncharacterized protein. (265 aa)
	SH2D1A	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (124 aa)
	STAP1	Signal transducing adaptor family member 1. (287 aa)
	BLK	Tyrosine-protein kinase. (500 aa)
	ELF1	E74 like ETS transcription factor 1. (618 aa)
	PTPRJ	Protein tyrosine phosphatase receptor type J. (1219 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (388 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1131 aa)
	CMTM3	CKLF like MARVEL transmembrane domain containing 3. (178 aa)
	EZR	Ezrin. (586 aa)
	PRKD2	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
	CD81	Tetraspanin. (287 aa)
	BCL10	BCL10 immune signaling adaptor. (241 aa)
	THY1	Thy-1 cell surface antigen. (161 aa)
	TESPA1	Thymocyte expressed, positive selection associated 1. (534 aa)
	PVR	Uncharacterized protein. (391 aa)
	M3Y544_MUSPF	Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
	KCNN4	Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4. (429 aa)
	CD22	CD22 molecule. (858 aa)
	SLC39A10	Solute carrier family 39 member 10. (837 aa)
	RPS3	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	UBASH3A	Ubiquitin associated and SH3 domain containing A. (626 aa)
	M3YDY7_MUSPF	Uncharacterized protein. (257 aa)
	M3YE25_MUSPF	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (153 aa)
	CBLB	Cbl proto-oncogene B. (983 aa)
	TRAT1	T cell receptor associated transmembrane adaptor 1. (187 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1298 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	M3YGX4_MUSPF	Uncharacterized protein. (369 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (511 aa)
	RAB29	RAB29, member RAS oncogene family. (204 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (577 aa)
	CD19	CD19 molecule. (560 aa)
	M3YS01_MUSPF	Ig-like domain-containing protein. (306 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	PVRIG	PVR related immunoglobulin domain containing. (290 aa)
	NFAM1	NFAT activating protein with ITAM motif 1. (261 aa)
	MALT1	MALT1 paracaspase. (716 aa)
	CD226	CD226 molecule. (336 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	FOXP1	Forkhead box P1. (676 aa)
	PAWR	Pro-apoptotic WT1 regulator. (360 aa)
	ADA	Adenosine deaminase. (363 aa)
	SLA2	Src like adaptor 2. (276 aa)
	CARD11	Caspase recruitment domain family member 11. (1153 aa)
	PRNP	Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (257 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL10	CARD11	ENSMPUP00000005407	ENSMPUP00000017839	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 11.	0.998
BCL10	MALT1	ENSMPUP00000005407	ENSMPUP00000016372	BCL10 immune signaling adaptor.	MALT1 paracaspase.	0.999
BCL10	PRKCB	ENSMPUP00000005407	ENSMPUP00000012100	BCL10 immune signaling adaptor.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.564
BCL10	RELA	ENSMPUP00000005407	ENSMPUP00000011545	BCL10 immune signaling adaptor.	RELA proto-oncogene, NF-kB subunit.	0.622
BCL10	UBASH3A	ENSMPUP00000005407	ENSMPUP00000009239	BCL10 immune signaling adaptor.	Ubiquitin associated and SH3 domain containing A.	0.446
BLK	CBLB	ENSMPUP00000001795	ENSMPUP00000009813	Tyrosine-protein kinase.	Cbl proto-oncogene B.	0.417
BLK	CD19	ENSMPUP00000001795	ENSMPUP00000012775	Tyrosine-protein kinase.	CD19 molecule.	0.781
BLK	CD22	ENSMPUP00000001795	ENSMPUP00000006948	Tyrosine-protein kinase.	CD22 molecule.	0.416
BLK	PTPRC	ENSMPUP00000001795	ENSMPUP00000010371	Tyrosine-protein kinase.	Protein tyrosine phosphatase receptor type C.	0.449
BLK	SH2D1A	ENSMPUP00000001795	ENSMPUP00000001336	Tyrosine-protein kinase.	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.	0.554
CARD11	BCL10	ENSMPUP00000017839	ENSMPUP00000005407	Caspase recruitment domain family member 11.	BCL10 immune signaling adaptor.	0.998
CARD11	M3Y544_MUSPF	ENSMPUP00000017839	ENSMPUP00000006445	Caspase recruitment domain family member 11.	Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...]	0.597
CARD11	MALT1	ENSMPUP00000017839	ENSMPUP00000016372	Caspase recruitment domain family member 11.	MALT1 paracaspase.	0.988
CARD11	PRKCB	ENSMPUP00000017839	ENSMPUP00000012100	Caspase recruitment domain family member 11.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.959
CARD11	PTPN6	ENSMPUP00000017839	ENSMPUP00000016662	Caspase recruitment domain family member 11.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.431
CARD11	RELA	ENSMPUP00000017839	ENSMPUP00000011545	Caspase recruitment domain family member 11.	RELA proto-oncogene, NF-kB subunit.	0.497
CBLB	BLK	ENSMPUP00000009813	ENSMPUP00000001795	Cbl proto-oncogene B.	Tyrosine-protein kinase.	0.417
CBLB	LYN	ENSMPUP00000009813	ENSMPUP00000010388	Cbl proto-oncogene B.	Tyrosine-protein kinase.	0.756
CBLB	PTPN6	ENSMPUP00000009813	ENSMPUP00000016662	Cbl proto-oncogene B.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.444
CBLB	SLA2	ENSMPUP00000009813	ENSMPUP00000017664	Cbl proto-oncogene B.	Src like adaptor 2.	0.825