(31 nodes) Positive regulation of muscle cell differentiation network (Mustela putorius)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	EDN1	Endothelin 1. (202 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (789 aa)
	ACTN3	Actinin alpha 3 (gene/pseudogene). (904 aa)
	RBM4	RNA binding motif protein 4. (365 aa)
	MYOCD	Myocardin. (980 aa)
	MAMSTR	MEF2 activating motif and SAP domain containing transcriptional regulator. (436 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	MYF5	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
	MYF6	Myogenic factor 6. (242 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	TARBP2	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (365 aa)
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (948 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
	MEF2C	Myocyte enhancer factor 2C. (433 aa)
	SMYD1	SET and MYND domain containing 1. (581 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	TRIM32	Tripartite motif containing 32. (673 aa)
	NEK5	NIMA related kinase 5. (787 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
	CAMK1	Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (409 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
	OLFM2	Olfactomedin 2. (386 aa)
	ENG	Endoglin. (653 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	SIRT1	Sirtuin 1. (557 aa)
	ATP11A	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1274 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN3	MYF6	ENSMPUP00000003128	ENSMPUP00000004906	Actinin alpha 3 (gene/pseudogene).	Myogenic factor 6.	0.539
BMP10	BMP4	ENSMPUP00000006259	ENSMPUP00000005423	Bone morphogenetic protein 10.	Bone morphogenetic protein 4.	0.573
BMP10	ENG	ENSMPUP00000006259	ENSMPUP00000013475	Bone morphogenetic protein 10.	Endoglin.	0.646
BMP4	BMP10	ENSMPUP00000005423	ENSMPUP00000006259	Bone morphogenetic protein 4.	Bone morphogenetic protein 10.	0.573
CAV3	ENG	ENSMPUP00000016953	ENSMPUP00000013475	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Endoglin.	0.691
CAV3	MYOD1	ENSMPUP00000016953	ENSMPUP00000013460	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.437
EDN1	ENG	ENSMPUP00000000674	ENSMPUP00000013475	Endothelin 1.	Endoglin.	0.526
ENG	BMP10	ENSMPUP00000013475	ENSMPUP00000006259	Endoglin.	Bone morphogenetic protein 10.	0.646
ENG	CAV3	ENSMPUP00000013475	ENSMPUP00000016953	Endoglin.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.691
ENG	EDN1	ENSMPUP00000013475	ENSMPUP00000000674	Endoglin.	Endothelin 1.	0.526
ENG	KIT	ENSMPUP00000013475	ENSMPUP00000006063	Endoglin.	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.465
IGF1	KIT	ENSMPUP00000011884	ENSMPUP00000006063	Insulin like growth factor 1.	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.608
KIT	ENG	ENSMPUP00000006063	ENSMPUP00000013475	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Endoglin.	0.465
KIT	IGF1	ENSMPUP00000006063	ENSMPUP00000011884	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Insulin like growth factor 1.	0.608
MAML1	MEF2C	ENSMPUP00000000682	ENSMPUP00000007906	Mastermind like transcriptional coactivator 1.	Myocyte enhancer factor 2C.	0.525
MAPK14	MEF2C	ENSMPUP00000003896	ENSMPUP00000007906	Mitogen-activated protein kinase.	Myocyte enhancer factor 2C.	0.918
MAPK14	MYOD1	ENSMPUP00000003896	ENSMPUP00000013460	Mitogen-activated protein kinase.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.457
MDM2	SIRT1	ENSMPUP00000017394	ENSMPUP00000011868	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	Sirtuin 1.	0.492
MEF2C	MAML1	ENSMPUP00000007906	ENSMPUP00000000682	Myocyte enhancer factor 2C.	Mastermind like transcriptional coactivator 1.	0.525
MEF2C	MAPK14	ENSMPUP00000007906	ENSMPUP00000003896	Myocyte enhancer factor 2C.	Mitogen-activated protein kinase.	0.918