(29 nodes) Regulation of telomerase activity network (Mustela putorius)

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Your Input:
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (698 aa)
	HMBOX1	Homeobox containing 1. (443 aa)
	M3XRQ6_MUSPF	G-patch domain-containing protein. (319 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (473 aa)
	PNKP	Polynucleotide kinase 3'-phosphatase. (520 aa)
	MAPK1	Mitogen-activated protein kinase. (333 aa)
	NVL	Nuclear VCP like. (854 aa)
	MAP3K4	Mitogen-activated protein kinase kinase kinase 4. (1463 aa)
	TCP1	T-complex 1. (556 aa)
	CCT4	T-complex protein 1 subunit delta. (539 aa)
	ACD	ACD shelterin complex subunit and telomerase recruitment factor. (495 aa)
	POT1	Protection of telomeres 1. (785 aa)
	WRAP53	WD repeat containing antisense to TP53. (539 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
	PARM1	Prostate androgen-regulated mucin-like protein 1. (332 aa)
	TERF1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (438 aa)
	NEK7	NIMA related kinase 7; Belongs to the protein kinase superfamily. (322 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1327 aa)
	PARP3	Poly [ADP-ribose] polymerase. (531 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
	PARP4	Poly [ADP-ribose] polymerase. (1556 aa)
	PARN	Poly(A)-specific ribonuclease. (638 aa)
	M3YVM5_MUSPF	TLC domain-containing protein. (267 aa)
	NEK2	NIMA related kinase 2. (444 aa)
	DKC1	Dyskerin pseudouridine synthase 1. (539 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	CCT2	Chaperonin containing TCP1 subunit 2. (535 aa)
	SRC	Tyrosine-protein kinase. (536 aa)
	GREM1	Gremlin. (184 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	DKC1	ENSMPUP00000006353	ENSMPUP00000016029	ACD shelterin complex subunit and telomerase recruitment factor.	Dyskerin pseudouridine synthase 1.	0.718
ACD	POT1	ENSMPUP00000006353	ENSMPUP00000006699	ACD shelterin complex subunit and telomerase recruitment factor.	Protection of telomeres 1.	0.998
ACD	TERF1	ENSMPUP00000006353	ENSMPUP00000010176	ACD shelterin complex subunit and telomerase recruitment factor.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.957
ACD	WRAP53	ENSMPUP00000006353	ENSMPUP00000008941	ACD shelterin complex subunit and telomerase recruitment factor.	WD repeat containing antisense to TP53.	0.638
CCT2	CCT4	ENSMPUP00000017388	ENSMPUP00000005570	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit delta.	0.999
CCT2	TCP1	ENSMPUP00000017388	ENSMPUP00000004981	Chaperonin containing TCP1 subunit 2.	T-complex 1.	0.999
CCT4	CCT2	ENSMPUP00000005570	ENSMPUP00000017388	T-complex protein 1 subunit delta.	Chaperonin containing TCP1 subunit 2.	0.999
CCT4	TCP1	ENSMPUP00000005570	ENSMPUP00000004981	T-complex protein 1 subunit delta.	T-complex 1.	0.999
DKC1	ACD	ENSMPUP00000016029	ENSMPUP00000006353	Dyskerin pseudouridine synthase 1.	ACD shelterin complex subunit and telomerase recruitment factor.	0.718
DKC1	NVL	ENSMPUP00000016029	ENSMPUP00000003998	Dyskerin pseudouridine synthase 1.	Nuclear VCP like.	0.502
DKC1	PARN	ENSMPUP00000016029	ENSMPUP00000014354	Dyskerin pseudouridine synthase 1.	Poly(A)-specific ribonuclease.	0.511
DKC1	PIF1	ENSMPUP00000016029	ENSMPUP00000000543	Dyskerin pseudouridine synthase 1.	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...]	0.567
DKC1	POT1	ENSMPUP00000016029	ENSMPUP00000006699	Dyskerin pseudouridine synthase 1.	Protection of telomeres 1.	0.662
DKC1	TERF1	ENSMPUP00000016029	ENSMPUP00000010176	Dyskerin pseudouridine synthase 1.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.623
DKC1	WRAP53	ENSMPUP00000016029	ENSMPUP00000008941	Dyskerin pseudouridine synthase 1.	WD repeat containing antisense to TP53.	0.995
M3XRQ6_MUSPF	TERF1	ENSMPUP00000001756	ENSMPUP00000010176	G-patch domain-containing protein.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.643
MAPK1	MAPK3	ENSMPUP00000003112	ENSMPUP00000012543	Mitogen-activated protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.927
MAPK1	MAPKAPK5	ENSMPUP00000003112	ENSMPUP00000002260	Mitogen-activated protein kinase.	MAPK activated protein kinase 5.	0.621
MAPK1	PRKCQ	ENSMPUP00000003112	ENSMPUP00000016259	Mitogen-activated protein kinase.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.427
MAPK1	SRC	ENSMPUP00000003112	ENSMPUP00000017650	Mitogen-activated protein kinase.	Tyrosine-protein kinase.	0.604