STRINGSTRING
WDR19 WDR19 CHD8 CHD8 SMAD3 SMAD3 FOXF2 FOXF2 NKX3-2 NKX3-2 RBPMS2 RBPMS2 FGF9 FGF9 EXT1 EXT1 RB1 RB1 C1GALT1 C1GALT1 ZIC3 ZIC3 GATA4 GATA4 HIP1R HIP1R EPHB3 EPHB3 SPDEF SPDEF SALL1 SALL1 NKX2-6 NKX2-6 TP63 TP63 CRKL CRKL HES1 HES1 MYOCD MYOCD HLX HLX TGFB2 TGFB2 NODAL NODAL BARX1 BARX1 ALDH1A2 ALDH1A2 YIPF6 YIPF6 HOXA5 HOXA5 KCNQ1 KCNQ1 SAV1 SAV1 PDX1 PDX1 BMP4 BMP4 SFRP2 SFRP2 GATA6 GATA6 IGF2 IGF2 CCKBR CCKBR PDGFRA PDGFRA M3Y377_MUSPF M3Y377_MUSPF CLMP CLMP SMO SMO WDPCP WDPCP ALX4 ALX4 KIT KIT HIF1A HIF1A YAP1 YAP1 RARRES2 RARRES2 IL6ST IL6ST MEGF8 MEGF8 GATA5 GATA5 FOXF1 FOXF1 WNT11 WNT11 PKDCC PKDCC DNAAF1 DNAAF1 CCDC103 CCDC103 CXCL8 CXCL8 CLDN18 CLDN18 TIGAR TIGAR PRDM1 PRDM1 M3YE59_MUSPF M3YE59_MUSPF NPHP3 NPHP3 M3YFG7_MUSPF M3YFG7_MUSPF KLF5 KLF5 SOX17 SOX17 LGR4 LGR4 NOTCH1 NOTCH1 TNF TNF RARB RARB CCDC40 CCDC40 COL3A1 COL3A1 PCSK5 PCSK5 SOX10 SOX10 AGR2 AGR2 SOX9 SOX9 FGF10 FGF10 C6orf58 C6orf58 TCF21 TCF21 AHI1 AHI1 NIPBL NIPBL TBX2 TBX2 PKD1 PKD1 SRP54 SRP54 IHH IHH NKX2-3 NKX2-3 STRA6 STRA6 ADA ADA SRC SRC GLI3 GLI3 COBL COBL FOXL1 FOXL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WDR19WD repeat domain 19. (1342 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2580 aa)
SMAD3Mothers against decapentaplegic homolog. (414 aa)
FOXF2Forkhead box F2. (415 aa)
NKX3-2NK3 homeobox 2. (331 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (200 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
RB1RB transcriptional corepressor 1. (948 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (367 aa)
ZIC3Zic family member 3. (473 aa)
GATA4GATA binding protein 4. (442 aa)
HIP1RHuntingtin interacting protein 1 related. (884 aa)
EPHB3EPH receptor B3. (959 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
SALL1Spalt like transcription factor 1. (1337 aa)
NKX2-6NK2 homeobox 6. (297 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (586 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
HES1Hes family bHLH transcription factor 1. (283 aa)
MYOCDMyocardin. (980 aa)
HLXH2.0 like homeobox. (449 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
NODALNodal growth differentiation factor. (348 aa)
BARX1BARX homeobox 1. (196 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
YIPF6Protein YIPF. (236 aa)
HOXA5Homeobox A5. (270 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (590 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
GATA6GATA binding protein 6. (482 aa)
IGF2Insulin like growth factor 2. (192 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (455 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
M3Y377_MUSPFNTR domain-containing protein. (233 aa)
CLMPCXADR like membrane protein. (362 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (790 aa)
WDPCPWD repeat containing planar cell polarity effector. (714 aa)
ALX4ALX homeobox 4. (409 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (948 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (824 aa)
YAP1Yes associated protein 1. (325 aa)
RARRES2Retinoic acid receptor responder 2. (163 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
MEGF8Multiple EGF like domains 8. (2396 aa)
GATA5GATA binding protein 5. (404 aa)
FOXF1Forkhead box F1. (321 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (294 aa)
DNAAF1Dynein assembly factor 1, axonemal. (657 aa)
CCDC103Coiled-coil domain containing 103. (240 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (259 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
PRDM1PR/SET domain 1. (818 aa)
M3YE59_MUSPFHH_signal domain-containing protein. (290 aa)
NPHP3TPR_REGION domain-containing protein. (1331 aa)
M3YFG7_MUSPFUncharacterized protein. (135 aa)
KLF5Kruppel like factor 5. (457 aa)
SOX17SRY-box transcription factor 17. (406 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (890 aa)
NOTCH1Notch receptor 1. (2119 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
RARBRetinoic acid receptor beta. (448 aa)
CCDC40Coiled-coil domain containing 40. (1142 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1753 aa)
SOX10SRY-box transcription factor 10. (602 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
SOX9SRY-box transcription factor 9. (522 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
C6orf58Chromosome 6 open reading frame 58. (338 aa)
TCF21Transcription factor 21. (179 aa)
AHI1Abelson helper integration site 1. (1171 aa)
NIPBLNipped-B protein. (2803 aa)
TBX2T-box transcription factor 2. (679 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4230 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
IHHIndian hedgehog signaling molecule. (384 aa)
NKX2-3NK2 homeobox 3. (281 aa)
STRA6Stimulated by retinoic acid 6. (684 aa)
ADAAdenosine deaminase. (363 aa)
SRCTyrosine-protein kinase. (536 aa)
GLI3GLI family zinc finger 3. (1585 aa)
COBLCordon-bleu WH2 repeat protein. (1316 aa)
FOXL1Forkhead box L1. (345 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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