node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GFAP | IL6 | ENSMPUP00000008804 | ENSMPUP00000013489 | Glial fibrillary acidic protein; Belongs to the intermediate filament family. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.810 |
GFAP | TNF | ENSMPUP00000008804 | ENSMPUP00000011297 | Glial fibrillary acidic protein; Belongs to the intermediate filament family. | Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. | 0.558 |
IL6 | GFAP | ENSMPUP00000013489 | ENSMPUP00000008804 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Glial fibrillary acidic protein; Belongs to the intermediate filament family. | 0.810 |
IL6 | KRAS | ENSMPUP00000013489 | ENSMPUP00000010217 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | KRAS proto-oncogene, GTPase. | 0.456 |
IL6 | TNF | ENSMPUP00000013489 | ENSMPUP00000011297 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. | 0.905 |
IL6 | VEGFC | ENSMPUP00000013489 | ENSMPUP00000012000 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.436 |
KRAS | IL6 | ENSMPUP00000010217 | ENSMPUP00000013489 | KRAS proto-oncogene, GTPase. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.456 |
KRAS | M3Y544_MUSPF | ENSMPUP00000010217 | ENSMPUP00000006445 | KRAS proto-oncogene, GTPase. | Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] | 0.412 |
KRAS | PRKCI | ENSMPUP00000010217 | ENSMPUP00000016999 | KRAS proto-oncogene, GTPase. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.466 |
KRAS | TNF | ENSMPUP00000010217 | ENSMPUP00000011297 | KRAS proto-oncogene, GTPase. | Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. | 0.444 |
M3Y544_MUSPF | KRAS | ENSMPUP00000006445 | ENSMPUP00000010217 | Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] | KRAS proto-oncogene, GTPase. | 0.412 |
M3Y544_MUSPF | PRKCI | ENSMPUP00000006445 | ENSMPUP00000016999 | Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.416 |
PRKCI | KRAS | ENSMPUP00000016999 | ENSMPUP00000010217 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | KRAS proto-oncogene, GTPase. | 0.466 |
PRKCI | M3Y544_MUSPF | ENSMPUP00000016999 | ENSMPUP00000006445 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] | 0.416 |
TNF | GFAP | ENSMPUP00000011297 | ENSMPUP00000008804 | Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. | Glial fibrillary acidic protein; Belongs to the intermediate filament family. | 0.558 |
TNF | IL6 | ENSMPUP00000011297 | ENSMPUP00000013489 | Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.905 |
TNF | KRAS | ENSMPUP00000011297 | ENSMPUP00000010217 | Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. | KRAS proto-oncogene, GTPase. | 0.444 |
VEGFC | IL6 | ENSMPUP00000012000 | ENSMPUP00000013489 | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.436 |