node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CACNA2D1 | KCNE3 | ENSMPUP00000018178 | ENSMPUP00000019405 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Potassium voltage-gated channel subfamily E regulatory subunit 3. | 0.441 |
CACNA2D1 | KCNH2 | ENSMPUP00000018178 | ENSMPUP00000007505 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Potassium voltage-gated channel subfamily H member 2. | 0.488 |
CACNA2D1 | KCNJ2 | ENSMPUP00000018178 | ENSMPUP00000019787 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Potassium voltage-gated channel subfamily J member 2. | 0.527 |
CACNA2D1 | KCNQ1 | ENSMPUP00000018178 | ENSMPUP00000005070 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. | 0.537 |
CACNA2D1 | SCN5A | ENSMPUP00000018178 | ENSMPUP00000002553 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.661 |
CAV1 | CAV3 | ENSMPUP00000007166 | ENSMPUP00000016953 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | 0.969 |
CAV1 | FLNA | ENSMPUP00000007166 | ENSMPUP00000009219 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Filamin A. | 0.637 |
CAV3 | CAV1 | ENSMPUP00000016953 | ENSMPUP00000007166 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | 0.969 |
CAV3 | KCNE2 | ENSMPUP00000016953 | ENSMPUP00000019101 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Potassium voltage-gated channel subfamily E regulatory subunit 2. | 0.477 |
CAV3 | KCNH2 | ENSMPUP00000016953 | ENSMPUP00000007505 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Potassium voltage-gated channel subfamily H member 2. | 0.450 |
CAV3 | KCNJ2 | ENSMPUP00000016953 | ENSMPUP00000019787 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Potassium voltage-gated channel subfamily J member 2. | 0.442 |
CAV3 | M3XQH2_MUSPF | ENSMPUP00000016953 | ENSMPUP00000001322 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Uncharacterized protein. | 0.422 |
CAV3 | SCN4B | ENSMPUP00000016953 | ENSMPUP00000004411 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Sodium voltage-gated channel beta subunit 4. | 0.416 |
CAV3 | SCN5A | ENSMPUP00000016953 | ENSMPUP00000002553 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.403 |
CAV3 | SNTA1 | ENSMPUP00000016953 | ENSMPUP00000017721 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Syntrophin alpha 1. | 0.514 |
FLNA | CAV1 | ENSMPUP00000009219 | ENSMPUP00000007166 | Filamin A. | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | 0.637 |
FLNA | WDR1 | ENSMPUP00000009219 | ENSMPUP00000007991 | Filamin A. | WD repeat domain 1. | 0.553 |
GJA5 | KCNA5 | ENSMPUP00000018352 | ENSMPUP00000019031 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Potassium voltage-gated channel subfamily A member 5; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (By similarity). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family [...] | 0.511 |
GJA5 | KCNE2 | ENSMPUP00000018352 | ENSMPUP00000019101 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Potassium voltage-gated channel subfamily E regulatory subunit 2. | 0.426 |
GJA5 | KCNH2 | ENSMPUP00000018352 | ENSMPUP00000007505 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Potassium voltage-gated channel subfamily H member 2. | 0.422 |